Tissue engineering and stem cell-based therapeutic strategies for premature ovarian insufficiency
Premature ovarian insufficiency (POI), also known as premature ovarian failure (POF), is a complex endocrine disease that commonly affects women under the age of 40. It is characterized by the cessation of ovarian function before the age of 40, leading to infertility and hormonal imbalances. The cur...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-03-01
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| Series: | Regenerative Therapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352320423001128 |
| _version_ | 1797268983083171840 |
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| author | Fatemeh Kuchakzadeh Jafar Ai Somayeh Ebrahimi-Barough |
| author_facet | Fatemeh Kuchakzadeh Jafar Ai Somayeh Ebrahimi-Barough |
| author_sort | Fatemeh Kuchakzadeh |
| collection | DOAJ |
| description | Premature ovarian insufficiency (POI), also known as premature ovarian failure (POF), is a complex endocrine disease that commonly affects women under the age of 40. It is characterized by the cessation of ovarian function before the age of 40, leading to infertility and hormonal imbalances. The currently available treatment options for POI are limited and often ineffective. Tissue engineering and stem cell-based therapeutic strategies have emerged as promising approaches to restore ovarian function and improve the quality of life for women affected by POI. This review aims to provide a comprehensive overview of the types of stem cells and biomaterials used in the treatment of POI, including their biological characteristics and mechanisms of action. It explores various sources of stem cells, including embryonic stem cells, induced pluripotent stem cells, and adult stem cells, and their potential applications in regenerating ovarian tissue. Additionally, this paper discusses the development of biomaterials and scaffolds that mimic the natural ovarian microenvironment and support the growth and maturation of ovarian cells and follicles. Furthermore, the review highlights the challenges and ethical considerations associated with tissue engineering and stem cell-based therapies for POI and proposes potential solutions to address these issues. Overall, this paper aims to provide a comprehensive overview of the current state of research in tissue engineering and stem cell-based therapeutic strategies for POI and offers insights into future directions for improving treatment outcomes in this debilitating condition. |
| first_indexed | 2024-03-09T15:36:06Z |
| format | Article |
| id | doaj.art-8001cb2176e540dfab634c578e1d75ec |
| institution | Directory Open Access Journal |
| issn | 2352-3204 |
| language | English |
| last_indexed | 2024-04-25T01:41:08Z |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Regenerative Therapy |
| spelling | doaj.art-8001cb2176e540dfab634c578e1d75ec2024-03-08T05:18:45ZengElsevierRegenerative Therapy2352-32042024-03-01251023Tissue engineering and stem cell-based therapeutic strategies for premature ovarian insufficiencyFatemeh Kuchakzadeh0Jafar Ai1Somayeh Ebrahimi-Barough2Department of Tissue Engineering, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, IranDepartment of Tissue Engineering, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, IranCorresponding author.; Department of Tissue Engineering, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, IranPremature ovarian insufficiency (POI), also known as premature ovarian failure (POF), is a complex endocrine disease that commonly affects women under the age of 40. It is characterized by the cessation of ovarian function before the age of 40, leading to infertility and hormonal imbalances. The currently available treatment options for POI are limited and often ineffective. Tissue engineering and stem cell-based therapeutic strategies have emerged as promising approaches to restore ovarian function and improve the quality of life for women affected by POI. This review aims to provide a comprehensive overview of the types of stem cells and biomaterials used in the treatment of POI, including their biological characteristics and mechanisms of action. It explores various sources of stem cells, including embryonic stem cells, induced pluripotent stem cells, and adult stem cells, and their potential applications in regenerating ovarian tissue. Additionally, this paper discusses the development of biomaterials and scaffolds that mimic the natural ovarian microenvironment and support the growth and maturation of ovarian cells and follicles. Furthermore, the review highlights the challenges and ethical considerations associated with tissue engineering and stem cell-based therapies for POI and proposes potential solutions to address these issues. Overall, this paper aims to provide a comprehensive overview of the current state of research in tissue engineering and stem cell-based therapeutic strategies for POI and offers insights into future directions for improving treatment outcomes in this debilitating condition.http://www.sciencedirect.com/science/article/pii/S2352320423001128Stem cellsBiomaterialsPrimary ovarian failureTissue engineeringRegenerative medicine |
| spellingShingle | Fatemeh Kuchakzadeh Jafar Ai Somayeh Ebrahimi-Barough Tissue engineering and stem cell-based therapeutic strategies for premature ovarian insufficiency Regenerative Therapy Stem cells Biomaterials Primary ovarian failure Tissue engineering Regenerative medicine |
| title | Tissue engineering and stem cell-based therapeutic strategies for premature ovarian insufficiency |
| title_full | Tissue engineering and stem cell-based therapeutic strategies for premature ovarian insufficiency |
| title_fullStr | Tissue engineering and stem cell-based therapeutic strategies for premature ovarian insufficiency |
| title_full_unstemmed | Tissue engineering and stem cell-based therapeutic strategies for premature ovarian insufficiency |
| title_short | Tissue engineering and stem cell-based therapeutic strategies for premature ovarian insufficiency |
| title_sort | tissue engineering and stem cell based therapeutic strategies for premature ovarian insufficiency |
| topic | Stem cells Biomaterials Primary ovarian failure Tissue engineering Regenerative medicine |
| url | http://www.sciencedirect.com/science/article/pii/S2352320423001128 |
| work_keys_str_mv | AT fatemehkuchakzadeh tissueengineeringandstemcellbasedtherapeuticstrategiesforprematureovarianinsufficiency AT jafarai tissueengineeringandstemcellbasedtherapeuticstrategiesforprematureovarianinsufficiency AT somayehebrahimibarough tissueengineeringandstemcellbasedtherapeuticstrategiesforprematureovarianinsufficiency |