COMPARISON OF INTERLEUKIN-6, PROCALCITONIN AND C-REACTIVE PROTEIN AS A DIAGNOSTIC BIOMARKER IN PATIENTS UROSEPSIS
Objective: To compare the diagnostic value of Interleukin-6 (IL-6), Procalcitonin (PCT) and C-Reactive Protein (CRP) in detecting urosepsis. Material & Methods: This study is an analytical descriptive cross-sectional study about the diagnostic value of IL-6, PCT, and CRP to determine the diagnos...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
IKATAN AHLI UROLOGI INDONESIA
2020-07-01
|
| Series: | Jurnal Urologi Indonesia |
| Subjects: | |
| Online Access: | http://juri.urologi.or.id/juri/article/view/516 |
| _version_ | 1818823719587414016 |
|---|---|
| author | Trisno Fajar Nursanto M. Ayodhia Soebadi Doddy M Soebadi |
| author_facet | Trisno Fajar Nursanto M. Ayodhia Soebadi Doddy M Soebadi |
| author_sort | Trisno Fajar Nursanto |
| collection | DOAJ |
| description | Objective: To compare the diagnostic value of Interleukin-6 (IL-6), Procalcitonin (PCT) and C-Reactive Protein (CRP) in detecting urosepsis. Material & Methods: This study is an analytical descriptive cross-sectional study about the diagnostic value of IL-6, PCT, and CRP to determine the diagnosis of urosepsis. The study sample consisted of all SIRS patients with urological disorders. The entire sample was examined by IL-6, PCT, CRP, and urine culture as the gold standard diagnosis. Data were analyzed using 2x2 table analysis and ROC curve to obtain AUC value. Results: There are a total of 36 samples in this study. With a cut-off 140 pg/ml, IL-6 provides a sensitivity, specificity, Positive Predictive Value (PPV), Negative Predictive Value (NPV), Positive Likelihood Ratio (+LR) and Negative Likelihood Ratio (-LR) was 95.8%, 83.3%, 92%, 90%, 5.75, and 0.05 with AUC 90.8% (95% IK 80.2% -100%, p<0.001). Sensitivity and specificity for PCT with cut off 0.65 ng/ml were 75% and 83.3%. The sensitivity and specificity for CRP with cut off 41 mg/l was 70.8% and 58.3%. The AUC of PCT and CRP was 81.1% and 66.5%. Conclusion: IL-6 has the best diagnostic value followed by PCT and CRP in urosepsis cases. IL-6 can be used as a biomarker diagnostic of urosepsis. |
| first_indexed | 2024-12-18T23:44:27Z |
| format | Article |
| id | doaj.art-8002d77e358149748d9abf4c389eeac4 |
| institution | Directory Open Access Journal |
| issn | 0853-442X 2355-1402 |
| language | English |
| last_indexed | 2024-12-18T23:44:27Z |
| publishDate | 2020-07-01 |
| publisher | IKATAN AHLI UROLOGI INDONESIA |
| record_format | Article |
| series | Jurnal Urologi Indonesia |
| spelling | doaj.art-8002d77e358149748d9abf4c389eeac42022-12-21T20:47:16ZengIKATAN AHLI UROLOGI INDONESIAJurnal Urologi Indonesia0853-442X2355-14022020-07-0127210.32421/juri.v27i2.516516COMPARISON OF INTERLEUKIN-6, PROCALCITONIN AND C-REACTIVE PROTEIN AS A DIAGNOSTIC BIOMARKER IN PATIENTS UROSEPSISTrisno Fajar Nursanto0M. Ayodhia Soebadi1Doddy M Soebadi2Department of Urology, Faculty of Medicine/Universitas Airlangga, Soetomo General Hospital, SurabayaDepartment of Urology, Faculty of Medicine/Universitas Airlangga, Soetomo General Hospital, SurabayaDepartment of Urology, Faculty of Medicine/Universitas Airlangga, Soetomo General Hospital, SurabayaObjective: To compare the diagnostic value of Interleukin-6 (IL-6), Procalcitonin (PCT) and C-Reactive Protein (CRP) in detecting urosepsis. Material & Methods: This study is an analytical descriptive cross-sectional study about the diagnostic value of IL-6, PCT, and CRP to determine the diagnosis of urosepsis. The study sample consisted of all SIRS patients with urological disorders. The entire sample was examined by IL-6, PCT, CRP, and urine culture as the gold standard diagnosis. Data were analyzed using 2x2 table analysis and ROC curve to obtain AUC value. Results: There are a total of 36 samples in this study. With a cut-off 140 pg/ml, IL-6 provides a sensitivity, specificity, Positive Predictive Value (PPV), Negative Predictive Value (NPV), Positive Likelihood Ratio (+LR) and Negative Likelihood Ratio (-LR) was 95.8%, 83.3%, 92%, 90%, 5.75, and 0.05 with AUC 90.8% (95% IK 80.2% -100%, p<0.001). Sensitivity and specificity for PCT with cut off 0.65 ng/ml were 75% and 83.3%. The sensitivity and specificity for CRP with cut off 41 mg/l was 70.8% and 58.3%. The AUC of PCT and CRP was 81.1% and 66.5%. Conclusion: IL-6 has the best diagnostic value followed by PCT and CRP in urosepsis cases. IL-6 can be used as a biomarker diagnostic of urosepsis.http://juri.urologi.or.id/juri/article/view/516IL-6PCTCRPUrine CultureDiagnostic Value |
| spellingShingle | Trisno Fajar Nursanto M. Ayodhia Soebadi Doddy M Soebadi COMPARISON OF INTERLEUKIN-6, PROCALCITONIN AND C-REACTIVE PROTEIN AS A DIAGNOSTIC BIOMARKER IN PATIENTS UROSEPSIS Jurnal Urologi Indonesia IL-6 PCT CRP Urine Culture Diagnostic Value |
| title | COMPARISON OF INTERLEUKIN-6, PROCALCITONIN AND C-REACTIVE PROTEIN AS A DIAGNOSTIC BIOMARKER IN PATIENTS UROSEPSIS |
| title_full | COMPARISON OF INTERLEUKIN-6, PROCALCITONIN AND C-REACTIVE PROTEIN AS A DIAGNOSTIC BIOMARKER IN PATIENTS UROSEPSIS |
| title_fullStr | COMPARISON OF INTERLEUKIN-6, PROCALCITONIN AND C-REACTIVE PROTEIN AS A DIAGNOSTIC BIOMARKER IN PATIENTS UROSEPSIS |
| title_full_unstemmed | COMPARISON OF INTERLEUKIN-6, PROCALCITONIN AND C-REACTIVE PROTEIN AS A DIAGNOSTIC BIOMARKER IN PATIENTS UROSEPSIS |
| title_short | COMPARISON OF INTERLEUKIN-6, PROCALCITONIN AND C-REACTIVE PROTEIN AS A DIAGNOSTIC BIOMARKER IN PATIENTS UROSEPSIS |
| title_sort | comparison of interleukin 6 procalcitonin and c reactive protein as a diagnostic biomarker in patients urosepsis |
| topic | IL-6 PCT CRP Urine Culture Diagnostic Value |
| url | http://juri.urologi.or.id/juri/article/view/516 |
| work_keys_str_mv | AT trisnofajarnursanto comparisonofinterleukin6procalcitoninandcreactiveproteinasadiagnosticbiomarkerinpatientsurosepsis AT mayodhiasoebadi comparisonofinterleukin6procalcitoninandcreactiveproteinasadiagnosticbiomarkerinpatientsurosepsis AT doddymsoebadi comparisonofinterleukin6procalcitoninandcreactiveproteinasadiagnosticbiomarkerinpatientsurosepsis |