Clinical observation on the treatment of papular pustular rosacea with 2% Fusidic acid cream combined with hyaluronic acid
Objective To evaluate the clinical efficacy of 2% Fusidic acid cream combined with hyaluronic acid in the treatment of papular pustular rosacea. Methods Seventy-two patients were randomly divided into the hyaluronic acid and the control groups, 36 patients per group. Both groups were given oral doxy...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | zho |
| Published: |
editoiral office of Journal of Diagnosis and Therapy on Dermato-venereology
2023-10-01
|
| Series: | Pifu-xingbing zhenliaoxue zazhi |
| Subjects: | |
| Online Access: | http://pfxbzlx.gdvdc.com/EN/10.3969/j.issn.1674-8468.2023.05.006 |
| _version_ | 1797374026895589376 |
|---|---|
| author | Chengshu XIE Dingfeng ZHOU Min LI Shengchao REN Junzhi LI |
| author_facet | Chengshu XIE Dingfeng ZHOU Min LI Shengchao REN Junzhi LI |
| author_sort | Chengshu XIE |
| collection | DOAJ |
| description | Objective To evaluate the clinical efficacy of 2% Fusidic acid cream combined with hyaluronic acid in the treatment of papular pustular rosacea. Methods Seventy-two patients were randomly divided into the hyaluronic acid and the control groups, 36 patients per group. Both groups were given oral doxycycline 100 mg, qd for 6 weeks and topical 2% Fusidic acid cream twice daily for 4 weeks. In the hyaluronic acid group, topical hyaluronic acid was also given twice daily for 8 weeks. At the enrollment, 2-, 4-, and 8-week follow-up, the IGA, number of inflammatory papules, DLQI score, and symptom score were compared between the two groups. Results Out of the 72 patients, 69 patients completed the study. Following 2 weeks of the treatment, both the cure rate and the rate of minimal clinically important difference (MCID) were significant higher in the hyaluronic acid group than in the controls (χ2=4.70, P=0.013 for cure rate; χ2=4.14, P=0.020 for MCID). However, neither the cure rate nor the rate of MCID differed significantly between the two groups at 4- and 8-week follow-up. Moreover, the symptom scores were lower in the hyaluronic acid group than in the controls at 2- and 4-week (t=-2.63, P=0.011; t=-4.62, P<0.001), but not at 8-week follow-up. Conclusion Treatments of rosacea with the combination of 2% Fusidic acid cream and hyaluronic acid can rapidly improve clinical symptoms and the quality of patients′ lives. |
| first_indexed | 2024-03-08T18:59:56Z |
| format | Article |
| id | doaj.art-800338527ece487f8d5857c835d04c5c |
| institution | Directory Open Access Journal |
| issn | 1674-8468 |
| language | zho |
| last_indexed | 2024-03-08T18:59:56Z |
| publishDate | 2023-10-01 |
| publisher | editoiral office of Journal of Diagnosis and Therapy on Dermato-venereology |
| record_format | Article |
| series | Pifu-xingbing zhenliaoxue zazhi |
| spelling | doaj.art-800338527ece487f8d5857c835d04c5c2023-12-28T06:54:48Zzhoeditoiral office of Journal of Diagnosis and Therapy on Dermato-venereologyPifu-xingbing zhenliaoxue zazhi1674-84682023-10-0130542843210.3969/j.issn.1674-8468.2023.05.006Clinical observation on the treatment of papular pustular rosacea with 2% Fusidic acid cream combined with hyaluronic acidChengshu XIEDingfeng ZHOUMin LIShengchao RENJunzhi LIObjective To evaluate the clinical efficacy of 2% Fusidic acid cream combined with hyaluronic acid in the treatment of papular pustular rosacea. Methods Seventy-two patients were randomly divided into the hyaluronic acid and the control groups, 36 patients per group. Both groups were given oral doxycycline 100 mg, qd for 6 weeks and topical 2% Fusidic acid cream twice daily for 4 weeks. In the hyaluronic acid group, topical hyaluronic acid was also given twice daily for 8 weeks. At the enrollment, 2-, 4-, and 8-week follow-up, the IGA, number of inflammatory papules, DLQI score, and symptom score were compared between the two groups. Results Out of the 72 patients, 69 patients completed the study. Following 2 weeks of the treatment, both the cure rate and the rate of minimal clinically important difference (MCID) were significant higher in the hyaluronic acid group than in the controls (χ2=4.70, P=0.013 for cure rate; χ2=4.14, P=0.020 for MCID). However, neither the cure rate nor the rate of MCID differed significantly between the two groups at 4- and 8-week follow-up. Moreover, the symptom scores were lower in the hyaluronic acid group than in the controls at 2- and 4-week (t=-2.63, P=0.011; t=-4.62, P<0.001), but not at 8-week follow-up. Conclusion Treatments of rosacea with the combination of 2% Fusidic acid cream and hyaluronic acid can rapidly improve clinical symptoms and the quality of patients′ lives.http://pfxbzlx.gdvdc.com/EN/10.3969/j.issn.1674-8468.2023.05.006hyaluronic acidrosaceaigadlqi |
| spellingShingle | Chengshu XIE Dingfeng ZHOU Min LI Shengchao REN Junzhi LI Clinical observation on the treatment of papular pustular rosacea with 2% Fusidic acid cream combined with hyaluronic acid Pifu-xingbing zhenliaoxue zazhi hyaluronic acid rosacea iga dlqi |
| title | Clinical observation on the treatment of papular pustular rosacea with 2% Fusidic acid cream combined with hyaluronic acid |
| title_full | Clinical observation on the treatment of papular pustular rosacea with 2% Fusidic acid cream combined with hyaluronic acid |
| title_fullStr | Clinical observation on the treatment of papular pustular rosacea with 2% Fusidic acid cream combined with hyaluronic acid |
| title_full_unstemmed | Clinical observation on the treatment of papular pustular rosacea with 2% Fusidic acid cream combined with hyaluronic acid |
| title_short | Clinical observation on the treatment of papular pustular rosacea with 2% Fusidic acid cream combined with hyaluronic acid |
| title_sort | clinical observation on the treatment of papular pustular rosacea with 2 fusidic acid cream combined with hyaluronic acid |
| topic | hyaluronic acid rosacea iga dlqi |
| url | http://pfxbzlx.gdvdc.com/EN/10.3969/j.issn.1674-8468.2023.05.006 |
| work_keys_str_mv | AT chengshuxie clinicalobservationonthetreatmentofpapularpustularrosaceawith2fusidicacidcreamcombinedwithhyaluronicacid AT dingfengzhou clinicalobservationonthetreatmentofpapularpustularrosaceawith2fusidicacidcreamcombinedwithhyaluronicacid AT minli clinicalobservationonthetreatmentofpapularpustularrosaceawith2fusidicacidcreamcombinedwithhyaluronicacid AT shengchaoren clinicalobservationonthetreatmentofpapularpustularrosaceawith2fusidicacidcreamcombinedwithhyaluronicacid AT junzhili clinicalobservationonthetreatmentofpapularpustularrosaceawith2fusidicacidcreamcombinedwithhyaluronicacid |