3-Chloro-4-fluoro-N-{[3-(4-methoxyphenyl)-1-phenyl-1H-pyrazol- 4-yl]methyl}aniline
A direct reductive amination of 3-(4-methoxyphenyl)-1-phenyl-1H-pyrazole-4-carbaldehyde 2 with 3-chloro-4-flouroaniline using NaBH4/I2 as a reducing agent is described. The reaction was carried out in MeOH under neutral conditions at room temperature to give the secondary amine, 3-chloro-4-fluoro-N-...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2009-11-01
|
| Series: | Molbank |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1422-8599/2009/4/M640/ |
| _version_ | 1818939109583880192 |
|---|---|
| author | Suresh Kumar Fasih Ahmad Sandhya Bawa |
| author_facet | Suresh Kumar Fasih Ahmad Sandhya Bawa |
| author_sort | Suresh Kumar |
| collection | DOAJ |
| description | A direct reductive amination of 3-(4-methoxyphenyl)-1-phenyl-1H-pyrazole-4-carbaldehyde 2 with 3-chloro-4-flouroaniline using NaBH4/I2 as a reducing agent is described. The reaction was carried out in MeOH under neutral conditions at room temperature to give the secondary amine, 3-chloro-4-fluoro-N-{[3-(4-methoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methyl}aniline (3). |
| first_indexed | 2024-12-20T06:18:31Z |
| format | Article |
| id | doaj.art-80040e49f91c4215b904ca4fba039f52 |
| institution | Directory Open Access Journal |
| issn | 1422-8599 |
| language | English |
| last_indexed | 2024-12-20T06:18:31Z |
| publishDate | 2009-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molbank |
| spelling | doaj.art-80040e49f91c4215b904ca4fba039f522022-12-21T19:50:29ZengMDPI AGMolbank1422-85992009-11-0120094M64010.3390/M6403-Chloro-4-fluoro-N-{[3-(4-methoxyphenyl)-1-phenyl-1H-pyrazol- 4-yl]methyl}anilineSuresh KumarFasih AhmadSandhya BawaA direct reductive amination of 3-(4-methoxyphenyl)-1-phenyl-1H-pyrazole-4-carbaldehyde 2 with 3-chloro-4-flouroaniline using NaBH4/I2 as a reducing agent is described. The reaction was carried out in MeOH under neutral conditions at room temperature to give the secondary amine, 3-chloro-4-fluoro-N-{[3-(4-methoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methyl}aniline (3).http://www.mdpi.com/1422-8599/2009/4/M640/n/a |
| spellingShingle | Suresh Kumar Fasih Ahmad Sandhya Bawa 3-Chloro-4-fluoro-N-{[3-(4-methoxyphenyl)-1-phenyl-1H-pyrazol- 4-yl]methyl}aniline Molbank n/a |
| title | 3-Chloro-4-fluoro-N-{[3-(4-methoxyphenyl)-1-phenyl-1H-pyrazol- 4-yl]methyl}aniline |
| title_full | 3-Chloro-4-fluoro-N-{[3-(4-methoxyphenyl)-1-phenyl-1H-pyrazol- 4-yl]methyl}aniline |
| title_fullStr | 3-Chloro-4-fluoro-N-{[3-(4-methoxyphenyl)-1-phenyl-1H-pyrazol- 4-yl]methyl}aniline |
| title_full_unstemmed | 3-Chloro-4-fluoro-N-{[3-(4-methoxyphenyl)-1-phenyl-1H-pyrazol- 4-yl]methyl}aniline |
| title_short | 3-Chloro-4-fluoro-N-{[3-(4-methoxyphenyl)-1-phenyl-1H-pyrazol- 4-yl]methyl}aniline |
| title_sort | 3 chloro 4 fluoro n 3 4 methoxyphenyl 1 phenyl 1h pyrazol 4 yl methyl aniline |
| topic | n/a |
| url | http://www.mdpi.com/1422-8599/2009/4/M640/ |
| work_keys_str_mv | AT sureshkumar 3chloro4fluoron34methoxyphenyl1phenyl1hpyrazol4ylmethylaniline AT fasihahmad 3chloro4fluoron34methoxyphenyl1phenyl1hpyrazol4ylmethylaniline AT sandhyabawa 3chloro4fluoron34methoxyphenyl1phenyl1hpyrazol4ylmethylaniline |