Gap Junction Dependent Cell Communication Is Modulated During Transdifferentiation of Mesenchymal Stem/Stromal Cells Towards Neuron-Like Cells

Gap Junction Dependent Cell Communication Is Modulated During Transdifferentiation of Mesenchymal Stem/Stromal Cells Towards Neuron-Like Cells

In vitro transdifferentiation of patient-derived mesenchymal stem/stromal cells (MSCs) into neurons is of special interest for treatment of neurodegenerative diseases. Although there are encouraging studies, little is known about physiological modulations during this transdifferentiation process. He...

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Bibliographic Details
Main Authors: Nadine Dilger, Anna-Lena Neehus, Klaudia Grieger, Andrea Hoffmann, Max Menssen, Anaclet Ngezahayo
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
mesenchymal stem/stromal cells
transdifferentiation
neuron
small molecules
gap junctions
connexins
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00869/full

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