Functional Downregulation of PD-L1 and PD-L2 by CpG and non-CpG Oligonucleotides in Melanoma Cells

Functional Downregulation of PD-L1 and PD-L2 by CpG and non-CpG Oligonucleotides in Melanoma Cells

The clinical application of immune checkpoint inhibitors represents a breakthrough progress in the treatment of metastasized melanoma and other tumor entities. In the present study, it was hypothesized that oligonucleotides (ODNs), known as modulators of the immune response, have an impact on the en...

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Bibliographic Details
Main Authors: Johannes Kleemann, Katja Steinhorst, Veronika König, Nadja Zöller, Jindrich Cinatl, Deniz Özistanbullu, Roland Kaufmann, Markus Meissner, Stefan Kippenberger
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Cancers
Subjects:
melanoma
checkpoint
PD-L1
PD-L2
oligonucleotide
quadruplex
Online Access:https://www.mdpi.com/2072-6694/14/19/4698

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