Determination of plasma transcobalamin-II and zinc levels in newly–diagnosed and long–standing grand mal epileptic patients

Background: The changes of plasma transcobalamin-II (TCII) and Zinc (Zn) Levels in epileptic patients are not clearly understood. The aim of the current study was to evaluate the plasma contents of TCII and Zn levels in newly–diagnosed epileptic seizure patients, long-standing grand mal epileptic pa...

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Main Authors: Amene Aman-Mohammady, Payam Saadat, Durdi Qujeq, Karimollah Hajian-Tilaki, Kiarash Saleki
Format: Article
Language:English
Published: Babol University of Medical Sciences 2023-03-01
Series:Caspian Journal of Internal Medicine
Subjects:
Online Access:http://caspjim.com/article-1-3357-en.html
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author Amene Aman-Mohammady
Payam Saadat
Durdi Qujeq
Karimollah Hajian-Tilaki
Kiarash Saleki
author_facet Amene Aman-Mohammady
Payam Saadat
Durdi Qujeq
Karimollah Hajian-Tilaki
Kiarash Saleki
author_sort Amene Aman-Mohammady
collection DOAJ
description Background: The changes of plasma transcobalamin-II (TCII) and Zinc (Zn) Levels in epileptic patients are not clearly understood. The aim of the current study was to evaluate the plasma contents of TCII and Zn levels in newly–diagnosed epileptic seizure patients, long-standing grand mal epileptic patients following treatment with sodium valproate and healthy control group. Methods: Thirty patients aged 36.76±12.91 years with newly–diagnosed and thirty long-standing grand mal epileptic patients aged 35.56 ±12.77 years were diagnosed based on the clinical symptoms. The control subjects were picked out from healthy individuals and matched to the patients, aged 36.30 ±12.80 years. Plasma Zn and TCN-2 was evaluated via spectrophotometry at 546 nm and 450 nm, respectively, using chimerical kits. Results: Plasma level of TCII in the newly–diagnosed epileptic seizures patients and long-standing grand mal epileptic patients were significantly increased, compared to the healthy controls [14.89 ±3.24 and 21.84± 2.73 vs. 9.55±1.24, (n=30)], respectively. Plasma level of Zn was decreased in the newly–diagnosed epileptic seizure patients, while it was increased in long-standing grand mal epileptic patients compared to the control group [69.28± 6.41 and 80.56 ±6.12 and vs.75.80±1.59, (n=30)], respectively. Conclusion: This study suggests that sodium valproate may disrupt the homeostatic balance of TCII and Zn, and cause abnormality of their serum level in newly–diagnosed epileptic seizure patients and long-standing grand mal epileptic patients. Further research is recommended to identify the underpinning for these changes.
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spelling doaj.art-8006b3ed4f444755a27bda943c1ff9bd2023-05-03T10:46:23ZengBabol University of Medical SciencesCaspian Journal of Internal Medicine2008-61642008-61722023-03-01142199204Determination of plasma transcobalamin-II and zinc levels in newly–diagnosed and long–standing grand mal epileptic patientsAmene Aman-Mohammady0Payam Saadat1Durdi Qujeq2Karimollah Hajian-Tilaki3Kiarash Saleki4 Babol university of Medical sciences, Babol, Iran Mobility Impairment Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran Department of Biochemistry, Babol University of Medical Sciences, Babol, Iran Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran Student Research Committee, Babol University of Medical Sciences, Babol, Iran Background: The changes of plasma transcobalamin-II (TCII) and Zinc (Zn) Levels in epileptic patients are not clearly understood. The aim of the current study was to evaluate the plasma contents of TCII and Zn levels in newly–diagnosed epileptic seizure patients, long-standing grand mal epileptic patients following treatment with sodium valproate and healthy control group. Methods: Thirty patients aged 36.76±12.91 years with newly–diagnosed and thirty long-standing grand mal epileptic patients aged 35.56 ±12.77 years were diagnosed based on the clinical symptoms. The control subjects were picked out from healthy individuals and matched to the patients, aged 36.30 ±12.80 years. Plasma Zn and TCN-2 was evaluated via spectrophotometry at 546 nm and 450 nm, respectively, using chimerical kits. Results: Plasma level of TCII in the newly–diagnosed epileptic seizures patients and long-standing grand mal epileptic patients were significantly increased, compared to the healthy controls [14.89 ±3.24 and 21.84± 2.73 vs. 9.55±1.24, (n=30)], respectively. Plasma level of Zn was decreased in the newly–diagnosed epileptic seizure patients, while it was increased in long-standing grand mal epileptic patients compared to the control group [69.28± 6.41 and 80.56 ±6.12 and vs.75.80±1.59, (n=30)], respectively. Conclusion: This study suggests that sodium valproate may disrupt the homeostatic balance of TCII and Zn, and cause abnormality of their serum level in newly–diagnosed epileptic seizure patients and long-standing grand mal epileptic patients. Further research is recommended to identify the underpinning for these changes.http://caspjim.com/article-1-3357-en.htmltranscobalamin-2zincnewly –diagnosedlong –standing grand malepileptic
spellingShingle Amene Aman-Mohammady
Payam Saadat
Durdi Qujeq
Karimollah Hajian-Tilaki
Kiarash Saleki
Determination of plasma transcobalamin-II and zinc levels in newly–diagnosed and long–standing grand mal epileptic patients
Caspian Journal of Internal Medicine
transcobalamin-2
zinc
newly –diagnosed
long –standing grand mal
epileptic
title Determination of plasma transcobalamin-II and zinc levels in newly–diagnosed and long–standing grand mal epileptic patients
title_full Determination of plasma transcobalamin-II and zinc levels in newly–diagnosed and long–standing grand mal epileptic patients
title_fullStr Determination of plasma transcobalamin-II and zinc levels in newly–diagnosed and long–standing grand mal epileptic patients
title_full_unstemmed Determination of plasma transcobalamin-II and zinc levels in newly–diagnosed and long–standing grand mal epileptic patients
title_short Determination of plasma transcobalamin-II and zinc levels in newly–diagnosed and long–standing grand mal epileptic patients
title_sort determination of plasma transcobalamin ii and zinc levels in newly diagnosed and long standing grand mal epileptic patients
topic transcobalamin-2
zinc
newly –diagnosed
long –standing grand mal
epileptic
url http://caspjim.com/article-1-3357-en.html
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