Prolonged β-adrenergic stimulation disperses ryanodine receptor clusters in cardiomyocytes and has implications for heart failure

Prolonged β-adrenergic stimulation disperses ryanodine receptor clusters in cardiomyocytes and has implications for heart failure

Ryanodine receptors (RyRs) exhibit dynamic arrangements in cardiomyocytes, and we previously showed that ‘dispersion’ of RyR clusters disrupts Ca2+ homeostasis during heart failure (HF) (Kolstad et al., eLife, 2018). Here, we investigated whether prolonged β-adrenergic stimulation, a hallmark of HF,...

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Bibliographic Details
Main Authors: Xin Shen, Jonas van den Brink, Anna Bergan-Dahl, Terje R Kolstad, Einar S Norden, Yufeng Hou, Martin Laasmaa, Yuriana Aguilar-Sanchez, Ann P Quick, Emil KS Espe, Ivar Sjaastad, Xander HT Wehrens, Andrew G Edwards, Christian Soeller, William E Louch
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-08-01
Series:eLife
Subjects:
calcium sparks
cardiomyocytes
ryanodine receptors
heart failure
phosphorylation
β-adrenergic stimulation
Online Access:https://elifesciences.org/articles/77725

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