Cachexia and advanced dementia
Abstract Cachexia is a complex metabolic process that is associated with several end‐stage organ diseases. It is known to be also associated with advanced dementia, although the pathophysiologic mechanisms are still largely unknown. The present narrative review is aimed at presenting recent insights...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-04-01
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| Series: | Journal of Cachexia, Sarcopenia and Muscle |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/jcsm.12380 |
| _version_ | 1797204539209678848 |
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| author | Cecilia Minaglia Chiara Giannotti Virginia Boccardi Patrizia Mecocci Gianluca Serafini Patrizio Odetti Fiammetta Monacelli |
| author_facet | Cecilia Minaglia Chiara Giannotti Virginia Boccardi Patrizia Mecocci Gianluca Serafini Patrizio Odetti Fiammetta Monacelli |
| author_sort | Cecilia Minaglia |
| collection | DOAJ |
| description | Abstract Cachexia is a complex metabolic process that is associated with several end‐stage organ diseases. It is known to be also associated with advanced dementia, although the pathophysiologic mechanisms are still largely unknown. The present narrative review is aimed at presenting recent insights concerning the pathophysiology of weight loss and wasting syndrome in dementia, the putative mechanisms involved in the dysregulation of energy balance, and the interplay among the chronic clinical conditions of sarcopenia, malnutrition, and frailty in the elderly. We discuss the clinical implications of these new insights, with particular attention to the challenging question of nutritional needs in advanced dementia and the utility of tube feeding in order to optimize the management of end‐stage dementia. |
| first_indexed | 2024-04-24T08:36:50Z |
| format | Article |
| id | doaj.art-800a27bae7c04272b9c11d264b20fb90 |
| institution | Directory Open Access Journal |
| issn | 2190-5991 2190-6009 |
| language | English |
| last_indexed | 2024-04-24T08:36:50Z |
| publishDate | 2019-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Cachexia, Sarcopenia and Muscle |
| spelling | doaj.art-800a27bae7c04272b9c11d264b20fb902024-04-16T16:43:25ZengWileyJournal of Cachexia, Sarcopenia and Muscle2190-59912190-60092019-04-0110226327710.1002/jcsm.12380Cachexia and advanced dementiaCecilia Minaglia0Chiara Giannotti1Virginia Boccardi2Patrizia Mecocci3Gianluca Serafini4Patrizio Odetti5Fiammetta Monacelli6Department of Internal Medicine and Medical Specialties (DIMI), Section of Geriatrics University of Genoa Genoa ItalyDepartment of Internal Medicine and Medical Specialties (DIMI), Section of Geriatrics University of Genoa Genoa ItalyDepartment of Medicine, Institute of Gerontology and Geriatrics University of Perugia Perugia ItalyDepartment of Medicine, Institute of Gerontology and Geriatrics University of Perugia Perugia ItalyDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health University of Genoa Genoa ItalyDepartment of Internal Medicine and Medical Specialties (DIMI), Section of Geriatrics University of Genoa Genoa ItalyDepartment of Internal Medicine and Medical Specialties (DIMI), Section of Geriatrics University of Genoa Genoa ItalyAbstract Cachexia is a complex metabolic process that is associated with several end‐stage organ diseases. It is known to be also associated with advanced dementia, although the pathophysiologic mechanisms are still largely unknown. The present narrative review is aimed at presenting recent insights concerning the pathophysiology of weight loss and wasting syndrome in dementia, the putative mechanisms involved in the dysregulation of energy balance, and the interplay among the chronic clinical conditions of sarcopenia, malnutrition, and frailty in the elderly. We discuss the clinical implications of these new insights, with particular attention to the challenging question of nutritional needs in advanced dementia and the utility of tube feeding in order to optimize the management of end‐stage dementia.https://doi.org/10.1002/jcsm.12380Advanced dementiaCachexiaFailure to thriveFrailtySarcopeniaSupportive care |
| spellingShingle | Cecilia Minaglia Chiara Giannotti Virginia Boccardi Patrizia Mecocci Gianluca Serafini Patrizio Odetti Fiammetta Monacelli Cachexia and advanced dementia Journal of Cachexia, Sarcopenia and Muscle Advanced dementia Cachexia Failure to thrive Frailty Sarcopenia Supportive care |
| title | Cachexia and advanced dementia |
| title_full | Cachexia and advanced dementia |
| title_fullStr | Cachexia and advanced dementia |
| title_full_unstemmed | Cachexia and advanced dementia |
| title_short | Cachexia and advanced dementia |
| title_sort | cachexia and advanced dementia |
| topic | Advanced dementia Cachexia Failure to thrive Frailty Sarcopenia Supportive care |
| url | https://doi.org/10.1002/jcsm.12380 |
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