Assessing the protection elicited by virus-like particles expressing the RSV pre-fusion F and tandem repeated G proteins against RSV rA2 line19F infection in mice

Assessing the protection elicited by virus-like particles expressing the RSV pre-fusion F and tandem repeated G proteins against RSV rA2 line19F infection in mice

Abstract Excessive pulmonary inflammation is the hallmark of respiratory syncytial virus (RSV) infection hindering efficacious RSV vaccine development. Yet, the vast majority of the experimental RSV vaccine studies use laboratory-adapted RSV strains that do not reflect the highly pathogenic and infl...

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Bibliographic Details
Main Authors: Min-Ju Kim, Ki Back Chu, Su-Hwa Lee, Jie Mao, Gi-Deok Eom, Keon-Woong Yoon, Eun-Kyung Moon, Fu-Shi Quan
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Respiratory Research
Subjects:
Respiratory syncytial virus (RSV)
rA2 line19F
Virus-like particles (VLPs)
Pre-fusion F antigen
Tandem repeated G protein
Vaccine
Online Access:https://doi.org/10.1186/s12931-023-02641-w

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