Effect of foxtail millet supplementation in comparison to atorvastatin on high-fat diet-induced hyperlipidemia in rats
Background: Hyperlipidemia can be defined as an increased concentration of lipids in the blood. Foxtail millet (FTM) is a nutrient-rich cereal containing several phytochemicals which have possible lipid-lowering and glucose-lowering abilities. Atorvastatin is an HMG Co-A Reductase Inhibitor commonly...
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Manipal College of Medical Sciences, Pokhara
2023-08-01
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| Series: | Asian Journal of Medical Sciences |
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| Online Access: | https://www.nepjol.info/index.php/AJMS/article/view/53596 |
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| author | Praneeth Reddy Onteddu Suguna Priya Bhuvaneshwari Gajala Shravya Edavaluru Chaitanya Kandula |
| author_facet | Praneeth Reddy Onteddu Suguna Priya Bhuvaneshwari Gajala Shravya Edavaluru Chaitanya Kandula |
| author_sort | Praneeth Reddy Onteddu |
| collection | DOAJ |
| description | Background: Hyperlipidemia can be defined as an increased concentration of lipids in the blood. Foxtail millet (FTM) is a nutrient-rich cereal containing several phytochemicals which have possible lipid-lowering and glucose-lowering abilities. Atorvastatin is an HMG Co-A Reductase Inhibitor commonly prescribed for Hyperlipidemia.
Aims and Objectives: The aim of this study was to compare the hypolipidemic effect of FTM with that of Atorvastatin in Sprague–Dawley rats.
Materials and Methods: Twelve 12 male Sprague–Dawley rats were segregated into Group-A and Group-B with six (6) rats in each group. The rats in both groups were fed high-fat diet for 21 days and for the next 21 days the 6 rats in Group-A were fed FTM in the form of pellets, the 6 rats in Group-B were administered Atorvastatin in a dose of 5 mg/kg. The body weight (BW) and lipid profiles of the rats were measured at three stages-day 0, day 21, and day 42.
Results: FTM showed an 18.1% rise in high-density lipoprotein (HDL-C). It showed a fall in BW, total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL-C), and very LDL (VLDL-C) which were 15.5%, 14.0%, 12.8%, 18.3%, and 16.0%, respectively. With Atorvastatin the rise in HDL-C was 13.4%. The fall in BW, TC, TG, LDL-C, and VLDL-C was 30.2%, 30.5%, 24.9%, 27.5%, and 34.4%, respectively.
Conclusion: The present study results showed that FTM had a noticeable positive effect on the lipid profile and BW in Dyslipidemia in comparison to Atorvastatin. |
| first_indexed | 2024-03-12T20:33:20Z |
| format | Article |
| id | doaj.art-800be81197874292afea07111d272180 |
| institution | Directory Open Access Journal |
| issn | 2467-9100 2091-0576 |
| language | English |
| last_indexed | 2024-03-12T20:33:20Z |
| publishDate | 2023-08-01 |
| publisher | Manipal College of Medical Sciences, Pokhara |
| record_format | Article |
| series | Asian Journal of Medical Sciences |
| spelling | doaj.art-800be81197874292afea07111d2721802023-08-01T16:29:07ZengManipal College of Medical Sciences, PokharaAsian Journal of Medical Sciences2467-91002091-05762023-08-011485055https://doi.org/10.3126/ajms.v14i8.53596Effect of foxtail millet supplementation in comparison to atorvastatin on high-fat diet-induced hyperlipidemia in ratsPraneeth Reddy Onteddu 0https://orcid.org/0009-0004-6620-6332Suguna Priya 1https://orcid.org/0000-0001-8874-3076Bhuvaneshwari Gajala 2https://orcid.org/0000-0002-2052-5301Shravya Edavaluru 3https://orcid.org/0009-0009-2118-2513Chaitanya Kandula 4https://orcid.org/0009-0008-3713-2249Final Year Postgraduate Resident, Department of Pharmacology, Gandhi Medical College, Musheerabad, Telangana, India Assistant Professor, Department of Pharmacology, Gandhi Medical College, Musheerabad, Telangana, India Professor and Head, Department of Pharmacology, Gandhi Medical College, Musheerabad, Telangana, India Intern, Kamineni Academy of Medical Sciences and Research Center, Hyderabad, Telangana, India Final Year Postgraduate Resident, Department of Pharmacology, Gandhi Medical College, Musheerabad, Telangana, India Background: Hyperlipidemia can be defined as an increased concentration of lipids in the blood. Foxtail millet (FTM) is a nutrient-rich cereal containing several phytochemicals which have possible lipid-lowering and glucose-lowering abilities. Atorvastatin is an HMG Co-A Reductase Inhibitor commonly prescribed for Hyperlipidemia. Aims and Objectives: The aim of this study was to compare the hypolipidemic effect of FTM with that of Atorvastatin in Sprague–Dawley rats. Materials and Methods: Twelve 12 male Sprague–Dawley rats were segregated into Group-A and Group-B with six (6) rats in each group. The rats in both groups were fed high-fat diet for 21 days and for the next 21 days the 6 rats in Group-A were fed FTM in the form of pellets, the 6 rats in Group-B were administered Atorvastatin in a dose of 5 mg/kg. The body weight (BW) and lipid profiles of the rats were measured at three stages-day 0, day 21, and day 42. Results: FTM showed an 18.1% rise in high-density lipoprotein (HDL-C). It showed a fall in BW, total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL-C), and very LDL (VLDL-C) which were 15.5%, 14.0%, 12.8%, 18.3%, and 16.0%, respectively. With Atorvastatin the rise in HDL-C was 13.4%. The fall in BW, TC, TG, LDL-C, and VLDL-C was 30.2%, 30.5%, 24.9%, 27.5%, and 34.4%, respectively. Conclusion: The present study results showed that FTM had a noticeable positive effect on the lipid profile and BW in Dyslipidemia in comparison to Atorvastatin.https://www.nepjol.info/index.php/AJMS/article/view/53596hyperlipidemia; foxtail millet; atorvastatin; sprague–dawley rats; dyslipidemia |
| spellingShingle | Praneeth Reddy Onteddu Suguna Priya Bhuvaneshwari Gajala Shravya Edavaluru Chaitanya Kandula Effect of foxtail millet supplementation in comparison to atorvastatin on high-fat diet-induced hyperlipidemia in rats Asian Journal of Medical Sciences hyperlipidemia; foxtail millet; atorvastatin; sprague–dawley rats; dyslipidemia |
| title | Effect of foxtail millet supplementation in comparison to atorvastatin on high-fat diet-induced hyperlipidemia in rats |
| title_full | Effect of foxtail millet supplementation in comparison to atorvastatin on high-fat diet-induced hyperlipidemia in rats |
| title_fullStr | Effect of foxtail millet supplementation in comparison to atorvastatin on high-fat diet-induced hyperlipidemia in rats |
| title_full_unstemmed | Effect of foxtail millet supplementation in comparison to atorvastatin on high-fat diet-induced hyperlipidemia in rats |
| title_short | Effect of foxtail millet supplementation in comparison to atorvastatin on high-fat diet-induced hyperlipidemia in rats |
| title_sort | effect of foxtail millet supplementation in comparison to atorvastatin on high fat diet induced hyperlipidemia in rats |
| topic | hyperlipidemia; foxtail millet; atorvastatin; sprague–dawley rats; dyslipidemia |
| url | https://www.nepjol.info/index.php/AJMS/article/view/53596 |
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