Hypertension of Developmental Origins: Consideration of Gut Microbiome in Animal Models
Hypertension is the leading cause of global disease burden. Hypertension can arise from early life. Animal models are valuable for giving cogent evidence of a causal relationship between various environmental insults in early life and the hypertension of developmental origins in later life. These in...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Biomedicines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9059/10/4/875 |
| _version_ | 1797436758786310144 |
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| author | You-Lin Tain Chien-Ning Hsu |
| author_facet | You-Lin Tain Chien-Ning Hsu |
| author_sort | You-Lin Tain |
| collection | DOAJ |
| description | Hypertension is the leading cause of global disease burden. Hypertension can arise from early life. Animal models are valuable for giving cogent evidence of a causal relationship between various environmental insults in early life and the hypertension of developmental origins in later life. These insults consist of maternal malnutrition, maternal medical conditions, medication use, and exposure to environmental chemicals/toxins. There is a burgeoning body of evidence on maternal insults can shift gut microbiota, resulting in adverse offspring outcomes later in life. Emerging evidence suggests that gut microbiota dysbiosis is involved in hypertension of developmental origins, while gut microbiota-targeted therapy, if applied early, is able to help prevent hypertension in later life. This review discusses the innovative use of animal models in addressing the mechanisms behind hypertension of developmental origins. We will also highlight the application of animal models to elucidate how the gut microbiota connects with other core mechanisms, and the potential of gut microbiota-targeted therapy as a novel preventive strategy to prevent hypertension of developmental origins. These animal models have certainly enhanced our understanding of hypertension of developmental origins, closing the knowledge gap between animal models and future clinical translation. |
| first_indexed | 2024-03-09T11:07:14Z |
| format | Article |
| id | doaj.art-800d2a40f387416895bfa93ed77cf6fa |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T11:07:14Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-800d2a40f387416895bfa93ed77cf6fa2023-12-01T00:54:42ZengMDPI AGBiomedicines2227-90592022-04-0110487510.3390/biomedicines10040875Hypertension of Developmental Origins: Consideration of Gut Microbiome in Animal ModelsYou-Lin Tain0Chien-Ning Hsu1Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, TaiwanDepartment of Pharmacy, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, TaiwanHypertension is the leading cause of global disease burden. Hypertension can arise from early life. Animal models are valuable for giving cogent evidence of a causal relationship between various environmental insults in early life and the hypertension of developmental origins in later life. These insults consist of maternal malnutrition, maternal medical conditions, medication use, and exposure to environmental chemicals/toxins. There is a burgeoning body of evidence on maternal insults can shift gut microbiota, resulting in adverse offspring outcomes later in life. Emerging evidence suggests that gut microbiota dysbiosis is involved in hypertension of developmental origins, while gut microbiota-targeted therapy, if applied early, is able to help prevent hypertension in later life. This review discusses the innovative use of animal models in addressing the mechanisms behind hypertension of developmental origins. We will also highlight the application of animal models to elucidate how the gut microbiota connects with other core mechanisms, and the potential of gut microbiota-targeted therapy as a novel preventive strategy to prevent hypertension of developmental origins. These animal models have certainly enhanced our understanding of hypertension of developmental origins, closing the knowledge gap between animal models and future clinical translation.https://www.mdpi.com/2227-9059/10/4/875developmental origins of health and disease (DOHaD)gut microbiotahypertensionshort chain fatty acidoxidative stressprobiotics |
| spellingShingle | You-Lin Tain Chien-Ning Hsu Hypertension of Developmental Origins: Consideration of Gut Microbiome in Animal Models Biomedicines developmental origins of health and disease (DOHaD) gut microbiota hypertension short chain fatty acid oxidative stress probiotics |
| title | Hypertension of Developmental Origins: Consideration of Gut Microbiome in Animal Models |
| title_full | Hypertension of Developmental Origins: Consideration of Gut Microbiome in Animal Models |
| title_fullStr | Hypertension of Developmental Origins: Consideration of Gut Microbiome in Animal Models |
| title_full_unstemmed | Hypertension of Developmental Origins: Consideration of Gut Microbiome in Animal Models |
| title_short | Hypertension of Developmental Origins: Consideration of Gut Microbiome in Animal Models |
| title_sort | hypertension of developmental origins consideration of gut microbiome in animal models |
| topic | developmental origins of health and disease (DOHaD) gut microbiota hypertension short chain fatty acid oxidative stress probiotics |
| url | https://www.mdpi.com/2227-9059/10/4/875 |
| work_keys_str_mv | AT youlintain hypertensionofdevelopmentaloriginsconsiderationofgutmicrobiomeinanimalmodels AT chienninghsu hypertensionofdevelopmentaloriginsconsiderationofgutmicrobiomeinanimalmodels |