The association between Obstructive Sleep Apnea and Alzheimer's Disease: a Meta-analysis perspective
Alzheimer’s disease (AD) and obstructive sleep apnea (OSA) are highly prevalent, chronic conditions with intriguing, yet poorly understood epidemiological overlap. To date, the amount of OSA syndrome present in patients with AD across literature remains unknown. To address this question, we collecte...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-04-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnagi.2016.00078/full |
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| author | Farnoosh eEmamian Farnoosh eEmamian Habibolah eKhazaie Masoud eTahmasian Guy D. Leschziner Guy D. Leschziner Mary J. Morrell Mary J. Morrell Ging-Yuek R. Hsiung Ivana eRosenzweig Ivana eRosenzweig Amir A Sepehry |
| author_facet | Farnoosh eEmamian Farnoosh eEmamian Habibolah eKhazaie Masoud eTahmasian Guy D. Leschziner Guy D. Leschziner Mary J. Morrell Mary J. Morrell Ging-Yuek R. Hsiung Ivana eRosenzweig Ivana eRosenzweig Amir A Sepehry |
| author_sort | Farnoosh eEmamian |
| collection | DOAJ |
| description | Alzheimer’s disease (AD) and obstructive sleep apnea (OSA) are highly prevalent, chronic conditions with intriguing, yet poorly understood epidemiological overlap. To date, the amount of OSA syndrome present in patients with AD across literature remains unknown. To address this question, we collected all available published clinical data and analyzed them through a quantitative meta-analytical approach. The results of our quantitative meta-analysis suggest that the aggregate odds ratio for OSA in AD versus healthy control was 5.05 and homogeneous. This reflects that patients with AD have a five times higher chance of presenting with OSA than cognitively non-impaired individuals of similar age. Moreover, these data suggest that around half of patients with AD have experienced OSA at some point after their initial diagnosis. The additive impact of progressive changes in sleep quality and structure, changes in cerebral blood flow and the cellular redox status in OSA patients may all be contributing factors to cognitive decline and may further aggravate AD progression. It is hoped that the high OSA rate in AD patients, as suggested by the findings of our meta-analysis, might provide a sufficient clinical incentive to alert clinicians the importance of screening patients for OSA in AD, and stimulate further research in this area. |
| first_indexed | 2024-04-13T06:15:27Z |
| format | Article |
| id | doaj.art-800d7a2053cd4dc4aac532e2c827bc02 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-04-13T06:15:27Z |
| publishDate | 2016-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-800d7a2053cd4dc4aac532e2c827bc022022-12-22T02:58:51ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652016-04-01810.3389/fnagi.2016.00078184744The association between Obstructive Sleep Apnea and Alzheimer's Disease: a Meta-analysis perspectiveFarnoosh eEmamian0Farnoosh eEmamian1Habibolah eKhazaie2Masoud eTahmasian3Guy D. Leschziner4Guy D. Leschziner5Mary J. Morrell6Mary J. Morrell7Ging-Yuek R. Hsiung8Ivana eRosenzweig9Ivana eRosenzweig10Amir A Sepehry11Sleep Disorders Research Center, Kermanshah University of Medical SciencesDepartment of Psychiatry, Razi Hospital, University of Social Welfare and Rehabilitation SciencesSleep Disorders Research Center, Kermanshah University of Medical SciencesSleep Disorders Research Center, Kermanshah University of Medical SciencesSleep Disorders Centre, Guy’s and St Thomas’ HospitalSleep and Brain Plasticity Centre, Department of Neuroimaging, IOPPN, King's College and Imperial CollegeSleep Disorders Centre, Guy’s and St Thomas’ HospitalAcademic Unit of Sleep and Breathing, National Heart and Lung Institute, Imperial College London, UK and NIHR Respiratory Disease Biomedical Research Unit at the Royal Brompton and Harefield NHS Foundation Trust and Imperial College LondonDivision of Neurology, Faculty of Medicine, University of British ColumbiaSleep Disorders Centre, Guy’s and St Thomas’ HospitalSleep and Brain Plasticity Centre, Department of Neuroimaging, IOPPN, King's College and Imperial CollegeDivision of Neurology, Faculty of Medicine, University of British ColumbiaAlzheimer’s disease (AD) and obstructive sleep apnea (OSA) are highly prevalent, chronic conditions with intriguing, yet poorly understood epidemiological overlap. To date, the amount of OSA syndrome present in patients with AD across literature remains unknown. To address this question, we collected all available published clinical data and analyzed them through a quantitative meta-analytical approach. The results of our quantitative meta-analysis suggest that the aggregate odds ratio for OSA in AD versus healthy control was 5.05 and homogeneous. This reflects that patients with AD have a five times higher chance of presenting with OSA than cognitively non-impaired individuals of similar age. Moreover, these data suggest that around half of patients with AD have experienced OSA at some point after their initial diagnosis. The additive impact of progressive changes in sleep quality and structure, changes in cerebral blood flow and the cellular redox status in OSA patients may all be contributing factors to cognitive decline and may further aggravate AD progression. It is hoped that the high OSA rate in AD patients, as suggested by the findings of our meta-analysis, might provide a sufficient clinical incentive to alert clinicians the importance of screening patients for OSA in AD, and stimulate further research in this area.http://journal.frontiersin.org/Journal/10.3389/fnagi.2016.00078/fullMeta-analysisAlzheimer’s diseaseobstructive sleep apneaprevalence.sleep-disordered breathing |
| spellingShingle | Farnoosh eEmamian Farnoosh eEmamian Habibolah eKhazaie Masoud eTahmasian Guy D. Leschziner Guy D. Leschziner Mary J. Morrell Mary J. Morrell Ging-Yuek R. Hsiung Ivana eRosenzweig Ivana eRosenzweig Amir A Sepehry The association between Obstructive Sleep Apnea and Alzheimer's Disease: a Meta-analysis perspective Frontiers in Aging Neuroscience Meta-analysis Alzheimer’s disease obstructive sleep apnea prevalence. sleep-disordered breathing |
| title | The association between Obstructive Sleep Apnea and Alzheimer's Disease: a Meta-analysis perspective |
| title_full | The association between Obstructive Sleep Apnea and Alzheimer's Disease: a Meta-analysis perspective |
| title_fullStr | The association between Obstructive Sleep Apnea and Alzheimer's Disease: a Meta-analysis perspective |
| title_full_unstemmed | The association between Obstructive Sleep Apnea and Alzheimer's Disease: a Meta-analysis perspective |
| title_short | The association between Obstructive Sleep Apnea and Alzheimer's Disease: a Meta-analysis perspective |
| title_sort | association between obstructive sleep apnea and alzheimer 39 s disease a meta analysis perspective |
| topic | Meta-analysis Alzheimer’s disease obstructive sleep apnea prevalence. sleep-disordered breathing |
| url | http://journal.frontiersin.org/Journal/10.3389/fnagi.2016.00078/full |
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