Advances in the treatment of macular corneal dystrophy
Macular corneal dystrophy(MCD)refers to corneal stromal dystrophy, which can cause progressive visual field defects. MCD belongs to autosomal recessive disease. Mutation of CHST 6 gene is considered to be a pathogenic factor. In general, full-thickness penetrating keratoplasty has become a standard...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Press of International Journal of Ophthalmology (IJO PRESS)
2019-11-01
|
| Series: | Guoji Yanke Zazhi |
| Subjects: | |
| Online Access: | http://ies.ijo.cn/cn_publish/2019/11/201911012.pdf |
| _version_ | 1818595241574268928 |
|---|---|
| author | Wen-Qing Shi Qi Lin Yi Shao |
| author_facet | Wen-Qing Shi Qi Lin Yi Shao |
| author_sort | Wen-Qing Shi |
| collection | DOAJ |
| description | Macular corneal dystrophy(MCD)refers to corneal stromal dystrophy, which can cause progressive visual field defects. MCD belongs to autosomal recessive disease. Mutation of CHST 6 gene is considered to be a pathogenic factor. In general, full-thickness penetrating keratoplasty has become a standard treatment for improving vision. Now more advanced surgical interventions such as deep anterior lamellar keratoplasty(DALK)and phototherapeutic keratectomy(PTK)have also been shown to be important in the treatment of MCD. Some new technologies, such as gene targeting therapy and enzyme replacement therapy, are also being studied as potential permanent solutions for MCD. The pathogenesis, genetic basis, clinical manifestations, treatment and prognosis of this disease are reviewed in this paper. |
| first_indexed | 2024-12-16T11:12:53Z |
| format | Article |
| id | doaj.art-800db3f36b8b4d1fa7f85759160d4aa6 |
| institution | Directory Open Access Journal |
| issn | 1672-5123 1672-5123 |
| language | English |
| last_indexed | 2024-12-16T11:12:53Z |
| publishDate | 2019-11-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | Guoji Yanke Zazhi |
| spelling | doaj.art-800db3f36b8b4d1fa7f85759160d4aa62022-12-21T22:33:40ZengPress of International Journal of Ophthalmology (IJO PRESS)Guoji Yanke Zazhi1672-51231672-51232019-11-0119111870187310.3980/j.issn.1672-5123.2019.11.12Advances in the treatment of macular corneal dystrophyWen-Qing Shi0Qi Lin1Yi Shao2Department of Ophthalmology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, ChinaDepartment of Ophthalmology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, ChinaDepartment of Ophthalmology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, ChinaMacular corneal dystrophy(MCD)refers to corneal stromal dystrophy, which can cause progressive visual field defects. MCD belongs to autosomal recessive disease. Mutation of CHST 6 gene is considered to be a pathogenic factor. In general, full-thickness penetrating keratoplasty has become a standard treatment for improving vision. Now more advanced surgical interventions such as deep anterior lamellar keratoplasty(DALK)and phototherapeutic keratectomy(PTK)have also been shown to be important in the treatment of MCD. Some new technologies, such as gene targeting therapy and enzyme replacement therapy, are also being studied as potential permanent solutions for MCD. The pathogenesis, genetic basis, clinical manifestations, treatment and prognosis of this disease are reviewed in this paper.http://ies.ijo.cn/cn_publish/2019/11/201911012.pdfmacular corneal dystrophyCHST6penetrating keratoplasty |
| spellingShingle | Wen-Qing Shi Qi Lin Yi Shao Advances in the treatment of macular corneal dystrophy Guoji Yanke Zazhi macular corneal dystrophy CHST6 penetrating keratoplasty |
| title | Advances in the treatment of macular corneal dystrophy |
| title_full | Advances in the treatment of macular corneal dystrophy |
| title_fullStr | Advances in the treatment of macular corneal dystrophy |
| title_full_unstemmed | Advances in the treatment of macular corneal dystrophy |
| title_short | Advances in the treatment of macular corneal dystrophy |
| title_sort | advances in the treatment of macular corneal dystrophy |
| topic | macular corneal dystrophy CHST6 penetrating keratoplasty |
| url | http://ies.ijo.cn/cn_publish/2019/11/201911012.pdf |
| work_keys_str_mv | AT wenqingshi advancesinthetreatmentofmacularcornealdystrophy AT qilin advancesinthetreatmentofmacularcornealdystrophy AT yishao advancesinthetreatmentofmacularcornealdystrophy |