The Metabolic Impact of Nonalcoholic Fatty Liver Disease on Cognitive Dysfunction: A Comprehensive Clinical and Pathophysiological Review
Nonalcoholic fatty liver disease (NAFLD) exponentially affects the global healthcare burden, and it is currently gaining increasing interest in relation to its potential impact on central nervous system (CNS) diseases, especially concerning cognitive deterioration and dementias. Overall, scientific...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-03-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/25/6/3337 |
| _version_ | 1797240690916196352 |
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| author | Mauro Giuffrè Nicola Merli Maura Pugliatti Rita Moretti |
| author_facet | Mauro Giuffrè Nicola Merli Maura Pugliatti Rita Moretti |
| author_sort | Mauro Giuffrè |
| collection | DOAJ |
| description | Nonalcoholic fatty liver disease (NAFLD) exponentially affects the global healthcare burden, and it is currently gaining increasing interest in relation to its potential impact on central nervous system (CNS) diseases, especially concerning cognitive deterioration and dementias. Overall, scientific research nowadays extends to different levels, exploring NAFLD’s putative proinflammatory mechanism of such dysmetabolic conditions, spreading out from the liver to a multisystemic involvement. The aim of this review is to analyze the most recent scientific literature on cognitive involvement in NAFLD, as well as understand its underlying potential background processes, i.e., neuroinflammation, the role of microbiota in the brain–liver–gut axis, hyperammonemia neurotoxicity, insulin resistance, free fatty acids, and vitamins. |
| first_indexed | 2024-04-24T18:11:27Z |
| format | Article |
| id | doaj.art-800e16f4b1744f2f932c76bd8ceaafbd |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-04-24T18:11:27Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-800e16f4b1744f2f932c76bd8ceaafbd2024-03-27T13:45:44ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672024-03-01256333710.3390/ijms25063337The Metabolic Impact of Nonalcoholic Fatty Liver Disease on Cognitive Dysfunction: A Comprehensive Clinical and Pathophysiological ReviewMauro Giuffrè0Nicola Merli1Maura Pugliatti2Rita Moretti3Department of Internal Medicine (Digestive Diseases), Yale School of Medicine, New Haven, CT 06511, USADepartment of Neuroscience and Rehabilitation, University of Ferrara, 44124 Ferrara, ItalyDepartment of Neuroscience and Rehabilitation, University of Ferrara, 44124 Ferrara, ItalyDepartment of Clinical, Medical and Surgical Sciences, University of Trieste, 34149 Trieste, ItalyNonalcoholic fatty liver disease (NAFLD) exponentially affects the global healthcare burden, and it is currently gaining increasing interest in relation to its potential impact on central nervous system (CNS) diseases, especially concerning cognitive deterioration and dementias. Overall, scientific research nowadays extends to different levels, exploring NAFLD’s putative proinflammatory mechanism of such dysmetabolic conditions, spreading out from the liver to a multisystemic involvement. The aim of this review is to analyze the most recent scientific literature on cognitive involvement in NAFLD, as well as understand its underlying potential background processes, i.e., neuroinflammation, the role of microbiota in the brain–liver–gut axis, hyperammonemia neurotoxicity, insulin resistance, free fatty acids, and vitamins.https://www.mdpi.com/1422-0067/25/6/3337NAFLDNASHinsulin resistancediabetesgut microbiotainflammation |
| spellingShingle | Mauro Giuffrè Nicola Merli Maura Pugliatti Rita Moretti The Metabolic Impact of Nonalcoholic Fatty Liver Disease on Cognitive Dysfunction: A Comprehensive Clinical and Pathophysiological Review International Journal of Molecular Sciences NAFLD NASH insulin resistance diabetes gut microbiota inflammation |
| title | The Metabolic Impact of Nonalcoholic Fatty Liver Disease on Cognitive Dysfunction: A Comprehensive Clinical and Pathophysiological Review |
| title_full | The Metabolic Impact of Nonalcoholic Fatty Liver Disease on Cognitive Dysfunction: A Comprehensive Clinical and Pathophysiological Review |
| title_fullStr | The Metabolic Impact of Nonalcoholic Fatty Liver Disease on Cognitive Dysfunction: A Comprehensive Clinical and Pathophysiological Review |
| title_full_unstemmed | The Metabolic Impact of Nonalcoholic Fatty Liver Disease on Cognitive Dysfunction: A Comprehensive Clinical and Pathophysiological Review |
| title_short | The Metabolic Impact of Nonalcoholic Fatty Liver Disease on Cognitive Dysfunction: A Comprehensive Clinical and Pathophysiological Review |
| title_sort | metabolic impact of nonalcoholic fatty liver disease on cognitive dysfunction a comprehensive clinical and pathophysiological review |
| topic | NAFLD NASH insulin resistance diabetes gut microbiota inflammation |
| url | https://www.mdpi.com/1422-0067/25/6/3337 |
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