Genetic Determinants of Neurobehavioral Responses to Caffeine Administration during Sleep Deprivation: A Randomized, Cross Over Study (NCT03859882)
This study investigated whether four single nucleotide polymorphisms (SNPs) moderated caffeine effects on vigilance and performance in a double-blind and crossover total sleep deprivation (TSD) protocol in 37 subjects. In caffeine (2 × 2.5 mg/kg/24 h) or placebo-controlled condition, subjects perfor...
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MDPI AG
2021-04-01
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| Online Access: | https://www.mdpi.com/2073-4425/12/4/555 |
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| author | Mégane Erblang Fabien Sauvet Catherine Drogou Michaël Quiquempoix Pascal Van Beers Mathias Guillard Arnaud Rabat Aurélie Trignol Cyprien Bourrilhon Marie-Claire Erkel Damien Léger Claire Thomas Danielle Gomez-Merino Mounir Chennaoui |
| author_facet | Mégane Erblang Fabien Sauvet Catherine Drogou Michaël Quiquempoix Pascal Van Beers Mathias Guillard Arnaud Rabat Aurélie Trignol Cyprien Bourrilhon Marie-Claire Erkel Damien Léger Claire Thomas Danielle Gomez-Merino Mounir Chennaoui |
| author_sort | Mégane Erblang |
| collection | DOAJ |
| description | This study investigated whether four single nucleotide polymorphisms (SNPs) moderated caffeine effects on vigilance and performance in a double-blind and crossover total sleep deprivation (TSD) protocol in 37 subjects. In caffeine (2 × 2.5 mg/kg/24 h) or placebo-controlled condition, subjects performed a psychomotor vigilance test (PVT) and reported sleepiness every six hours (Karolinska sleepiness scale (KSS)) during TSD. EEG was also analyzed during the 09:15 PVT. Carriers of the TNF-α SNP A allele appear to be more sensitive than homozygote G/G genotype to an attenuating effect of caffeine on PVT lapses during sleep deprivation only because they seem more degraded, but they do not perform better as a result. The A allele carriers of COMT were also more degraded and sensitive to caffeine than G/G genotype after 20 h of sleep deprivation, but not after 26 and 32 h. Regarding PVT reaction time, ADORA2A influences the TSD effect but not caffeine, and PER3 modulates only the caffeine effect. Higher EEG theta activity related to sleep deprivation was observed in mutated TNF-α, PER3, and COMT carriers, in the placebo condition particularly. In conclusion, there are genetic influences on neurobehavioral impairments related to TSD that appear to be attenuated by caffeine administration. (NCT03859882). |
| first_indexed | 2024-03-10T12:26:10Z |
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| id | doaj.art-800ecd5d92c34765aabbe201ff8053b2 |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-10T12:26:10Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-800ecd5d92c34765aabbe201ff8053b22023-11-21T15:02:04ZengMDPI AGGenes2073-44252021-04-0112455510.3390/genes12040555Genetic Determinants of Neurobehavioral Responses to Caffeine Administration during Sleep Deprivation: A Randomized, Cross Over Study (NCT03859882)Mégane Erblang0Fabien Sauvet1Catherine Drogou2Michaël Quiquempoix3Pascal Van Beers4Mathias Guillard5Arnaud Rabat6Aurélie Trignol7Cyprien Bourrilhon8Marie-Claire Erkel9Damien Léger10Claire Thomas11Danielle Gomez-Merino12Mounir Chennaoui13Institut de Recherche Biomédicale des Armées (IRBA), 91190 Brétigny sur Orge, FranceInstitut de Recherche Biomédicale des Armées (IRBA), 91190 Brétigny sur Orge, FranceInstitut de Recherche Biomédicale des Armées (IRBA), 91190 Brétigny sur Orge, FranceInstitut de Recherche Biomédicale des Armées (IRBA), 91190 Brétigny sur Orge, FranceInstitut de Recherche Biomédicale des Armées (IRBA), 91190 Brétigny sur Orge, FranceInstitut de Recherche Biomédicale des Armées (IRBA), 91190 Brétigny sur Orge, FranceInstitut de Recherche Biomédicale des Armées (IRBA), 91190 Brétigny sur Orge, FranceInstitut de Recherche Biomédicale des Armées (IRBA), 91190 Brétigny sur Orge, FranceInstitut de Recherche Biomédicale des Armées (IRBA), 91190 Brétigny sur Orge, FranceInstitut de Recherche Biomédicale des Armées (IRBA), 91190 Brétigny sur Orge, FranceEA VIFASOM (EA 7330 Vigilance, Fatigue, Sommeil et Santé Publique), Université de Paris, 75004 Paris, FranceLBEPS, Univ Evry, IRBA, Université Paris Saclay, 91025 Evry, FranceInstitut de Recherche Biomédicale des Armées (IRBA), 91190 Brétigny sur Orge, FranceInstitut de Recherche Biomédicale des Armées (IRBA), 91190 Brétigny sur Orge, FranceThis study investigated whether four single nucleotide polymorphisms (SNPs) moderated caffeine effects on vigilance and performance in a double-blind and crossover total sleep deprivation (TSD) protocol in 37 subjects. In caffeine (2 × 2.5 mg/kg/24 h) or placebo-controlled condition, subjects performed a psychomotor vigilance test (PVT) and reported sleepiness every six hours (Karolinska sleepiness scale (KSS)) during TSD. EEG was also analyzed during the 09:15 PVT. Carriers of the TNF-α SNP A allele appear to be more sensitive than homozygote G/G genotype to an attenuating effect of caffeine on PVT lapses during sleep deprivation only because they seem more degraded, but they do not perform better as a result. The A allele carriers of COMT were also more degraded and sensitive to caffeine than G/G genotype after 20 h of sleep deprivation, but not after 26 and 32 h. Regarding PVT reaction time, ADORA2A influences the TSD effect but not caffeine, and PER3 modulates only the caffeine effect. Higher EEG theta activity related to sleep deprivation was observed in mutated TNF-α, PER3, and COMT carriers, in the placebo condition particularly. In conclusion, there are genetic influences on neurobehavioral impairments related to TSD that appear to be attenuated by caffeine administration. (NCT03859882).https://www.mdpi.com/2073-4425/12/4/555geneticscaffeinetotal sleep deprivationPVTpro-inflammatory cytokineadenosine |
| spellingShingle | Mégane Erblang Fabien Sauvet Catherine Drogou Michaël Quiquempoix Pascal Van Beers Mathias Guillard Arnaud Rabat Aurélie Trignol Cyprien Bourrilhon Marie-Claire Erkel Damien Léger Claire Thomas Danielle Gomez-Merino Mounir Chennaoui Genetic Determinants of Neurobehavioral Responses to Caffeine Administration during Sleep Deprivation: A Randomized, Cross Over Study (NCT03859882) Genes genetics caffeine total sleep deprivation PVT pro-inflammatory cytokine adenosine |
| title | Genetic Determinants of Neurobehavioral Responses to Caffeine Administration during Sleep Deprivation: A Randomized, Cross Over Study (NCT03859882) |
| title_full | Genetic Determinants of Neurobehavioral Responses to Caffeine Administration during Sleep Deprivation: A Randomized, Cross Over Study (NCT03859882) |
| title_fullStr | Genetic Determinants of Neurobehavioral Responses to Caffeine Administration during Sleep Deprivation: A Randomized, Cross Over Study (NCT03859882) |
| title_full_unstemmed | Genetic Determinants of Neurobehavioral Responses to Caffeine Administration during Sleep Deprivation: A Randomized, Cross Over Study (NCT03859882) |
| title_short | Genetic Determinants of Neurobehavioral Responses to Caffeine Administration during Sleep Deprivation: A Randomized, Cross Over Study (NCT03859882) |
| title_sort | genetic determinants of neurobehavioral responses to caffeine administration during sleep deprivation a randomized cross over study nct03859882 |
| topic | genetics caffeine total sleep deprivation PVT pro-inflammatory cytokine adenosine |
| url | https://www.mdpi.com/2073-4425/12/4/555 |
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