A Comprehensive Analysis of Radiosensitization Properties of Metallic Nanoparticles in Brachytherapy of Gastric Adenocarcinoma by I-125 Seed: A Simulation Study by MCNPX and MCNP6 Codes
<b>Purpose</b>: In the current study, we aimed to look into the macroscopic and microscopic dose enhancement effect of metallic nanoparticles in interstitial brachytherapy of gastric adenocarcinoma by Iodine-125 source using a nano-lattice model in MCNPX (2.7) and MCNP6.1 codes. <b>...
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| Format: | Article |
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MDPI AG
2022-08-01
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| Series: | Magnetochemistry |
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| Online Access: | https://www.mdpi.com/2312-7481/8/9/97 |
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| author | Elham Mansouri Asghar Mesbahi Mohammad Saeid Hejazi Vahideh Tarhriz Hamed Hamishehkar Farshad Seyednejad |
| author_facet | Elham Mansouri Asghar Mesbahi Mohammad Saeid Hejazi Vahideh Tarhriz Hamed Hamishehkar Farshad Seyednejad |
| author_sort | Elham Mansouri |
| collection | DOAJ |
| description | <b>Purpose</b>: In the current study, we aimed to look into the macroscopic and microscopic dose enhancement effect of metallic nanoparticles in interstitial brachytherapy of gastric adenocarcinoma by Iodine-125 source using a nano-lattice model in MCNPX (2.7) and MCNP6.1 codes. <b>Materials and methods</b>: Based on a nano-lattice simulation model containing a radiation source and a tumor tissue with cellular compartments loaded with 7 mg/g spherical nanoparticles, the microscopic and macroscopic levels of energy deposition by the secondary electrons was estimated. <b>Results</b>: The results show that the values of macroscopic DEF are higher than microscopic DEF values and the macroscopic DEF values decrease by increasing the distance from the surface of brachytherapy source. Accordingly, it could be noted that gold nanoparticles have the highest radiosensitization effect among the other nanoparticles and the related DEF value is close to the resultant DEF values for bismuth nanoparticles. Moreover, the results revealed a remarkable discrepancy between the DEF and secondary electron spectra calculated by MCNPX (2.7) and MCNP6.1 codes, which could be justified by the difference in energy cut-off and electron transport algorithms of two codes. <b>Conclusions</b>: According to the both MCNPX (2.7) and MCNP6.1 outputs, it could be concluded that the presence of metallic nanoparticles in the tumor tissue of gastric adenocarcinoma increases the physical effectiveness of brachytherapy by I-125 source. This study aims to provide recommendations for future preclinical studies. Actually, the results presented herein give a physical view of radiosensitization potential of different metallic nanoparticles and could be considered in design of analytical and experimental radiosensitization studies in tumor regions using various radiotherapy modalities in the presence of heavy nanomaterials. |
| first_indexed | 2024-03-09T23:20:36Z |
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| issn | 2312-7481 |
| language | English |
| last_indexed | 2024-03-09T23:20:36Z |
| publishDate | 2022-08-01 |
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| record_format | Article |
| series | Magnetochemistry |
| spelling | doaj.art-800f839e151a4974b0777e2b1b33e6362023-11-23T17:27:49ZengMDPI AGMagnetochemistry2312-74812022-08-01899710.3390/magnetochemistry8090097A Comprehensive Analysis of Radiosensitization Properties of Metallic Nanoparticles in Brachytherapy of Gastric Adenocarcinoma by I-125 Seed: A Simulation Study by MCNPX and MCNP6 CodesElham Mansouri0Asghar Mesbahi1Mohammad Saeid Hejazi2Vahideh Tarhriz3Hamed Hamishehkar4Farshad Seyednejad5Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz 51664-14766, IranMolecular Medicine Research Center, Institute of Biomedicine, Tabriz University of Medical Sciences, Tabriz 51664-14766, IranMolecular Medicine Research Center, Institute of Biomedicine, Tabriz University of Medical Sciences, Tabriz 51664-14766, IranMolecular Medicine Research Center, Institute of Biomedicine, Tabriz University of Medical Sciences, Tabriz 51664-14766, IranDrug Applied Research Center, Tabriz University of Medical Sciences, Tabriz 51664-14766, IranDepartment of Radiation Oncology, Madani Hospital, Tabriz University of Medical Sciences, Tabriz 51664-14766, Iran<b>Purpose</b>: In the current study, we aimed to look into the macroscopic and microscopic dose enhancement effect of metallic nanoparticles in interstitial brachytherapy of gastric adenocarcinoma by Iodine-125 source using a nano-lattice model in MCNPX (2.7) and MCNP6.1 codes. <b>Materials and methods</b>: Based on a nano-lattice simulation model containing a radiation source and a tumor tissue with cellular compartments loaded with 7 mg/g spherical nanoparticles, the microscopic and macroscopic levels of energy deposition by the secondary electrons was estimated. <b>Results</b>: The results show that the values of macroscopic DEF are higher than microscopic DEF values and the macroscopic DEF values decrease by increasing the distance from the surface of brachytherapy source. Accordingly, it could be noted that gold nanoparticles have the highest radiosensitization effect among the other nanoparticles and the related DEF value is close to the resultant DEF values for bismuth nanoparticles. Moreover, the results revealed a remarkable discrepancy between the DEF and secondary electron spectra calculated by MCNPX (2.7) and MCNP6.1 codes, which could be justified by the difference in energy cut-off and electron transport algorithms of two codes. <b>Conclusions</b>: According to the both MCNPX (2.7) and MCNP6.1 outputs, it could be concluded that the presence of metallic nanoparticles in the tumor tissue of gastric adenocarcinoma increases the physical effectiveness of brachytherapy by I-125 source. This study aims to provide recommendations for future preclinical studies. Actually, the results presented herein give a physical view of radiosensitization potential of different metallic nanoparticles and could be considered in design of analytical and experimental radiosensitization studies in tumor regions using various radiotherapy modalities in the presence of heavy nanomaterials.https://www.mdpi.com/2312-7481/8/9/97MCNP6MCNPXradiosensitizationbrachytherapynanoparticle |
| spellingShingle | Elham Mansouri Asghar Mesbahi Mohammad Saeid Hejazi Vahideh Tarhriz Hamed Hamishehkar Farshad Seyednejad A Comprehensive Analysis of Radiosensitization Properties of Metallic Nanoparticles in Brachytherapy of Gastric Adenocarcinoma by I-125 Seed: A Simulation Study by MCNPX and MCNP6 Codes Magnetochemistry MCNP6 MCNPX radiosensitization brachytherapy nanoparticle |
| title | A Comprehensive Analysis of Radiosensitization Properties of Metallic Nanoparticles in Brachytherapy of Gastric Adenocarcinoma by I-125 Seed: A Simulation Study by MCNPX and MCNP6 Codes |
| title_full | A Comprehensive Analysis of Radiosensitization Properties of Metallic Nanoparticles in Brachytherapy of Gastric Adenocarcinoma by I-125 Seed: A Simulation Study by MCNPX and MCNP6 Codes |
| title_fullStr | A Comprehensive Analysis of Radiosensitization Properties of Metallic Nanoparticles in Brachytherapy of Gastric Adenocarcinoma by I-125 Seed: A Simulation Study by MCNPX and MCNP6 Codes |
| title_full_unstemmed | A Comprehensive Analysis of Radiosensitization Properties of Metallic Nanoparticles in Brachytherapy of Gastric Adenocarcinoma by I-125 Seed: A Simulation Study by MCNPX and MCNP6 Codes |
| title_short | A Comprehensive Analysis of Radiosensitization Properties of Metallic Nanoparticles in Brachytherapy of Gastric Adenocarcinoma by I-125 Seed: A Simulation Study by MCNPX and MCNP6 Codes |
| title_sort | comprehensive analysis of radiosensitization properties of metallic nanoparticles in brachytherapy of gastric adenocarcinoma by i 125 seed a simulation study by mcnpx and mcnp6 codes |
| topic | MCNP6 MCNPX radiosensitization brachytherapy nanoparticle |
| url | https://www.mdpi.com/2312-7481/8/9/97 |
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