Mechanisms of bacillary dysentery: lessons learnt from infant rabbits
The bacterial pathogen Shigella flexneri causes more than 250 million cases of bacillary dysentery (blood in stool) every year across the world. This human-specific disease is characterized by profuse bloody diarrhea, dramatic ulceration of the colonic epithelium and immune cell infiltration of the...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2020-05-01
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| Series: | Gut Microbes |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/19490976.2019.1667726 |
| _version_ | 1818822124789301248 |
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| author | Lauren K. Yum Hervé Agaisse |
| author_facet | Lauren K. Yum Hervé Agaisse |
| author_sort | Lauren K. Yum |
| collection | DOAJ |
| description | The bacterial pathogen Shigella flexneri causes more than 250 million cases of bacillary dysentery (blood in stool) every year across the world. This human-specific disease is characterized by profuse bloody diarrhea, dramatic ulceration of the colonic epithelium and immune cell infiltration of the colonic tissue. A major challenge in understanding the mechanisms supporting bacillary dysentery is the reliance on animal models that do not fully recapitulate the symptoms observed in humans, including bloody diarrhea. Here we outline advances provided by a recently developed infant rabbit model of bacillary dysentery. The infant rabbit model defines bacillary dysentery as a critical combination of massive vascular lesions and dramatic epithelial fenestration due to intracellular infection and cell-to-cell spread, respectively. The infant rabbit model provides an unprecedented framework for understanding how the cell biology of Shigella flexneri infection relates to pathogenesis. |
| first_indexed | 2024-12-18T23:19:06Z |
| format | Article |
| id | doaj.art-8010567f7e604578ab7f102dc727e7cc |
| institution | Directory Open Access Journal |
| issn | 1949-0976 1949-0984 |
| language | English |
| last_indexed | 2024-12-18T23:19:06Z |
| publishDate | 2020-05-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Gut Microbes |
| spelling | doaj.art-8010567f7e604578ab7f102dc727e7cc2022-12-21T20:48:04ZengTaylor & Francis GroupGut Microbes1949-09761949-09842020-05-0111359760210.1080/19490976.2019.16677261667726Mechanisms of bacillary dysentery: lessons learnt from infant rabbitsLauren K. Yum0Hervé Agaisse1University of Virginia School of MedicineUniversity of Virginia School of MedicineThe bacterial pathogen Shigella flexneri causes more than 250 million cases of bacillary dysentery (blood in stool) every year across the world. This human-specific disease is characterized by profuse bloody diarrhea, dramatic ulceration of the colonic epithelium and immune cell infiltration of the colonic tissue. A major challenge in understanding the mechanisms supporting bacillary dysentery is the reliance on animal models that do not fully recapitulate the symptoms observed in humans, including bloody diarrhea. Here we outline advances provided by a recently developed infant rabbit model of bacillary dysentery. The infant rabbit model defines bacillary dysentery as a critical combination of massive vascular lesions and dramatic epithelial fenestration due to intracellular infection and cell-to-cell spread, respectively. The infant rabbit model provides an unprecedented framework for understanding how the cell biology of Shigella flexneri infection relates to pathogenesis.http://dx.doi.org/10.1080/19490976.2019.1667726shigella flexneribacillary dysenteryt3sscell-to-cell spreadrabbitepithelial fenestrationvascular lesion |
| spellingShingle | Lauren K. Yum Hervé Agaisse Mechanisms of bacillary dysentery: lessons learnt from infant rabbits Gut Microbes shigella flexneri bacillary dysentery t3ss cell-to-cell spread rabbit epithelial fenestration vascular lesion |
| title | Mechanisms of bacillary dysentery: lessons learnt from infant rabbits |
| title_full | Mechanisms of bacillary dysentery: lessons learnt from infant rabbits |
| title_fullStr | Mechanisms of bacillary dysentery: lessons learnt from infant rabbits |
| title_full_unstemmed | Mechanisms of bacillary dysentery: lessons learnt from infant rabbits |
| title_short | Mechanisms of bacillary dysentery: lessons learnt from infant rabbits |
| title_sort | mechanisms of bacillary dysentery lessons learnt from infant rabbits |
| topic | shigella flexneri bacillary dysentery t3ss cell-to-cell spread rabbit epithelial fenestration vascular lesion |
| url | http://dx.doi.org/10.1080/19490976.2019.1667726 |
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