Dipyridodiazepinone derivatives; synthesis and anti HIV-1 activity

Dipyridodiazepinone derivatives; synthesis and anti HIV-1 activity

Ten dipyridodiazepinone derivatives were synthesized and evaluated for their anti HIV-1 reverse transcriptase activity against wild-type and mutant type enzymes, K103N and Y181C. Two of them were found to be promising inhibitors for HIV-1 RT.

Bibliographic Details
Main Authors:	Nisachon Khunnawutmanotham, Nitirat Chimnoi, Arunee Thitithanyanont, Patchreenart Saparpakorn, Kiattawee Choowongkomon, Pornpan Pungpo, Supa Hannongbua, Supanna Techasakul
Format:	Article
Language:	English
Published:	Beilstein-Institut 2009-07-01
Series:	Beilstein Journal of Organic Chemistry
Subjects:	AIDS anti HIV-1 RT dipyridodiazepinone nevirapine synthesis
Online Access:	https://doi.org/10.3762/bjoc.5.36

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