Immunomodulatory Activity of Polysaccharide-Protein Complex of Longan (Dimocarpus longan Lour.) Pulp
The immunomodulatory function of longan pulp polysaccharide-protein complex (LP3) was investigated in immunosuppressed mice models. Compared with the model control, peroral administration of 100 mgkg−1d−1 LP3 could significantly increase/enhance antibody production against chicken red blood cell (CR...
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| Format: | Article |
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MDPI AG
2011-12-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/16/12/10324/ |
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| author | Zhen-Cheng Wei Bao Yang Yuan-Yuan Deng Rui-Fen Zhang Yang Yi Ming-Wei Zhang Sen-Tai Liao |
| author_facet | Zhen-Cheng Wei Bao Yang Yuan-Yuan Deng Rui-Fen Zhang Yang Yi Ming-Wei Zhang Sen-Tai Liao |
| author_sort | Zhen-Cheng Wei |
| collection | DOAJ |
| description | The immunomodulatory function of longan pulp polysaccharide-protein complex (LP3) was investigated in immunosuppressed mice models. Compared with the model control, peroral administration of 100 mgkg−1d−1 LP3 could significantly increase/enhance antibody production against chicken red blood cell (CRBC), concanavalin A (ConA)-induced splenocyte proliferation, macrophage phagocytosis, NK cell cytotoxicity against YAC-1 lymphoma cell, and interferon-gamma (INF-γ) and interleukin-2 (IL-2) secretion in serum (P < 0.05). The immunomodulatory effects, except for those on splenocytes and macrophages (P > 0.05), were also observed in mice administered with 50 or 200 mgkg−1d−1 LP3 (P < 0.05). The beneficial effects of 50–200 mgkg−1d−1 LP3 were comparable to those of 50 mgkg−1d−1 ganoderan. The strong immunomodulatory activity of LP3 confirmed its good potential as an immunotherapeutic adjuvant. |
| first_indexed | 2024-04-12T23:35:06Z |
| format | Article |
| id | doaj.art-8012db71e15a47928241df20f32a3967 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-04-12T23:35:06Z |
| publishDate | 2011-12-01 |
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| record_format | Article |
| series | Molecules |
| spelling | doaj.art-8012db71e15a47928241df20f32a39672022-12-22T03:12:10ZengMDPI AGMolecules1420-30492011-12-011612103241033610.3390/molecules161210324Immunomodulatory Activity of Polysaccharide-Protein Complex of Longan (Dimocarpus longan Lour.) PulpZhen-Cheng WeiBao YangYuan-Yuan DengRui-Fen ZhangYang YiMing-Wei ZhangSen-Tai LiaoThe immunomodulatory function of longan pulp polysaccharide-protein complex (LP3) was investigated in immunosuppressed mice models. Compared with the model control, peroral administration of 100 mgkg−1d−1 LP3 could significantly increase/enhance antibody production against chicken red blood cell (CRBC), concanavalin A (ConA)-induced splenocyte proliferation, macrophage phagocytosis, NK cell cytotoxicity against YAC-1 lymphoma cell, and interferon-gamma (INF-γ) and interleukin-2 (IL-2) secretion in serum (P < 0.05). The immunomodulatory effects, except for those on splenocytes and macrophages (P > 0.05), were also observed in mice administered with 50 or 200 mgkg−1d−1 LP3 (P < 0.05). The beneficial effects of 50–200 mgkg−1d−1 LP3 were comparable to those of 50 mgkg−1d−1 ganoderan. The strong immunomodulatory activity of LP3 confirmed its good potential as an immunotherapeutic adjuvant.http://www.mdpi.com/1420-3049/16/12/10324/longan pulppolysaccharide-protein compleximmunomodulatory activityimmunosuppressed micecyclophosphamide |
| spellingShingle | Zhen-Cheng Wei Bao Yang Yuan-Yuan Deng Rui-Fen Zhang Yang Yi Ming-Wei Zhang Sen-Tai Liao Immunomodulatory Activity of Polysaccharide-Protein Complex of Longan (Dimocarpus longan Lour.) Pulp Molecules longan pulp polysaccharide-protein complex immunomodulatory activity immunosuppressed mice cyclophosphamide |
| title | Immunomodulatory Activity of Polysaccharide-Protein Complex of Longan (Dimocarpus longan Lour.) Pulp |
| title_full | Immunomodulatory Activity of Polysaccharide-Protein Complex of Longan (Dimocarpus longan Lour.) Pulp |
| title_fullStr | Immunomodulatory Activity of Polysaccharide-Protein Complex of Longan (Dimocarpus longan Lour.) Pulp |
| title_full_unstemmed | Immunomodulatory Activity of Polysaccharide-Protein Complex of Longan (Dimocarpus longan Lour.) Pulp |
| title_short | Immunomodulatory Activity of Polysaccharide-Protein Complex of Longan (Dimocarpus longan Lour.) Pulp |
| title_sort | immunomodulatory activity of polysaccharide protein complex of longan dimocarpus longan lour pulp |
| topic | longan pulp polysaccharide-protein complex immunomodulatory activity immunosuppressed mice cyclophosphamide |
| url | http://www.mdpi.com/1420-3049/16/12/10324/ |
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