Synthesis of gold nanoparticles from leaf Panax notoginseng and its anticancer activity in pancreatic cancer PANC-1 cell lines
Development of novel methods is needed for the synthesis of nanoparticles. Attention on such particles has elevated disquiet about the eco-friendly manner of their fabrication methods. In the present study, we equipped and synthesized gold nanoparticles (AuNPs) from Panax notoginseng; investigated a...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2019-12-01
|
| Series: | Artificial Cells, Nanomedicine, and Biotechnology |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/21691401.2019.1593852 |
| _version_ | 1818140139828805632 |
|---|---|
| author | Lei Wang Jianwei Xu Ye Yan Han Liu Feng Li |
| author_facet | Lei Wang Jianwei Xu Ye Yan Han Liu Feng Li |
| author_sort | Lei Wang |
| collection | DOAJ |
| description | Development of novel methods is needed for the synthesis of nanoparticles. Attention on such particles has elevated disquiet about the eco-friendly manner of their fabrication methods. In the present study, we equipped and synthesized gold nanoparticles (AuNPs) from Panax notoginseng; investigated as an environmentally friendly and non-toxic substrate. Amalgamation of AuNPs was distinguished by numerous studies such as UV-absorbance and it shows peak values in the range of 520–550 nm. Nanoparticles sizes are confirmed by dynamic light scattering analysis and it shows 100 nm. Moreover, transmission electron microscopy (TEM) and energy dispersive X-ray analysis (EDX) confirmed the shape of the Au particles present in the synthesized materials. FTIR analysis studies showed the active molecules positioned in the plane of the synthesized particles. The anticancer potential of AuNPs was evaluated in PANC-1 cells. Additionally, AuNPs efficiently induced cytotoxicity, ROS and apoptosis by intonating intrinsic apoptotic gene expressions in PANC-1 cells. Finally, our study confirmed the synthesis of AuNPs from Panax notoginseng, which showed anticancer effects in an environmentally friendly manner. |
| first_indexed | 2024-12-11T10:39:14Z |
| format | Article |
| id | doaj.art-801456c848be47eeaf04fafe23f479fa |
| institution | Directory Open Access Journal |
| issn | 2169-1401 2169-141X |
| language | English |
| last_indexed | 2024-12-11T10:39:14Z |
| publishDate | 2019-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Artificial Cells, Nanomedicine, and Biotechnology |
| spelling | doaj.art-801456c848be47eeaf04fafe23f479fa2022-12-22T01:10:37ZengTaylor & Francis GroupArtificial Cells, Nanomedicine, and Biotechnology2169-14012169-141X2019-12-014711216122310.1080/21691401.2019.1593852Synthesis of gold nanoparticles from leaf Panax notoginseng and its anticancer activity in pancreatic cancer PANC-1 cell linesLei Wang0Jianwei Xu1Ye Yan2Han Liu3Feng Li4Department of General Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, ChinaDepartment of General Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, ChinaDepartment of Ultrasound and Radiology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, ChinaDepartment of General Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, ChinaDepartment of General Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, ChinaDevelopment of novel methods is needed for the synthesis of nanoparticles. Attention on such particles has elevated disquiet about the eco-friendly manner of their fabrication methods. In the present study, we equipped and synthesized gold nanoparticles (AuNPs) from Panax notoginseng; investigated as an environmentally friendly and non-toxic substrate. Amalgamation of AuNPs was distinguished by numerous studies such as UV-absorbance and it shows peak values in the range of 520–550 nm. Nanoparticles sizes are confirmed by dynamic light scattering analysis and it shows 100 nm. Moreover, transmission electron microscopy (TEM) and energy dispersive X-ray analysis (EDX) confirmed the shape of the Au particles present in the synthesized materials. FTIR analysis studies showed the active molecules positioned in the plane of the synthesized particles. The anticancer potential of AuNPs was evaluated in PANC-1 cells. Additionally, AuNPs efficiently induced cytotoxicity, ROS and apoptosis by intonating intrinsic apoptotic gene expressions in PANC-1 cells. Finally, our study confirmed the synthesis of AuNPs from Panax notoginseng, which showed anticancer effects in an environmentally friendly manner.https://www.tandfonline.com/doi/10.1080/21691401.2019.1593852Gold nanoparticlesPanax notoginsengPANC-1 cellspancreatic cancer |
| spellingShingle | Lei Wang Jianwei Xu Ye Yan Han Liu Feng Li Synthesis of gold nanoparticles from leaf Panax notoginseng and its anticancer activity in pancreatic cancer PANC-1 cell lines Artificial Cells, Nanomedicine, and Biotechnology Gold nanoparticles Panax notoginseng PANC-1 cells pancreatic cancer |
| title | Synthesis of gold nanoparticles from leaf Panax notoginseng and its anticancer activity in pancreatic cancer PANC-1 cell lines |
| title_full | Synthesis of gold nanoparticles from leaf Panax notoginseng and its anticancer activity in pancreatic cancer PANC-1 cell lines |
| title_fullStr | Synthesis of gold nanoparticles from leaf Panax notoginseng and its anticancer activity in pancreatic cancer PANC-1 cell lines |
| title_full_unstemmed | Synthesis of gold nanoparticles from leaf Panax notoginseng and its anticancer activity in pancreatic cancer PANC-1 cell lines |
| title_short | Synthesis of gold nanoparticles from leaf Panax notoginseng and its anticancer activity in pancreatic cancer PANC-1 cell lines |
| title_sort | synthesis of gold nanoparticles from leaf panax notoginseng and its anticancer activity in pancreatic cancer panc 1 cell lines |
| topic | Gold nanoparticles Panax notoginseng PANC-1 cells pancreatic cancer |
| url | https://www.tandfonline.com/doi/10.1080/21691401.2019.1593852 |
| work_keys_str_mv | AT leiwang synthesisofgoldnanoparticlesfromleafpanaxnotoginsenganditsanticanceractivityinpancreaticcancerpanc1celllines AT jianweixu synthesisofgoldnanoparticlesfromleafpanaxnotoginsenganditsanticanceractivityinpancreaticcancerpanc1celllines AT yeyan synthesisofgoldnanoparticlesfromleafpanaxnotoginsenganditsanticanceractivityinpancreaticcancerpanc1celllines AT hanliu synthesisofgoldnanoparticlesfromleafpanaxnotoginsenganditsanticanceractivityinpancreaticcancerpanc1celllines AT fengli synthesisofgoldnanoparticlesfromleafpanaxnotoginsenganditsanticanceractivityinpancreaticcancerpanc1celllines |