Functional IKK/NF-κB signaling in pancreatic stellate cells is essential to prevent autoimmune pancreatitis
A model of autoimmune pancreatitis is developed by blocking the activation of NF-κB in pancreatic stellate cells, via conditional deletion of NEMO (IKKγ), which presents strong pancreatic inflammation with eosinophilia after the induction of chronic pancreatitis by repeated caerulein challenges.
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-05-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-022-03371-3 |
| _version_ | 1818204687650783232 |
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| author | Lap Kwan Chan Miltiadis Tsesmelis Melanie Gerstenlauer Frank Leithäuser Alexander Kleger Lukas Daniel Frick Harald Jacob Maier Thomas Wirth |
| author_facet | Lap Kwan Chan Miltiadis Tsesmelis Melanie Gerstenlauer Frank Leithäuser Alexander Kleger Lukas Daniel Frick Harald Jacob Maier Thomas Wirth |
| author_sort | Lap Kwan Chan |
| collection | DOAJ |
| description | A model of autoimmune pancreatitis is developed by blocking the activation of NF-κB in pancreatic stellate cells, via conditional deletion of NEMO (IKKγ), which presents strong pancreatic inflammation with eosinophilia after the induction of chronic pancreatitis by repeated caerulein challenges. |
| first_indexed | 2024-12-12T03:45:12Z |
| format | Article |
| id | doaj.art-80177109f28e4bcf87f4e4ede8c9e652 |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-12-12T03:45:12Z |
| publishDate | 2022-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-80177109f28e4bcf87f4e4ede8c9e6522022-12-22T00:39:35ZengNature PortfolioCommunications Biology2399-36422022-05-015111610.1038/s42003-022-03371-3Functional IKK/NF-κB signaling in pancreatic stellate cells is essential to prevent autoimmune pancreatitisLap Kwan Chan0Miltiadis Tsesmelis1Melanie Gerstenlauer2Frank Leithäuser3Alexander Kleger4Lukas Daniel Frick5Harald Jacob Maier6Thomas Wirth7Institute of Physiological Chemistry, University of UlmInstitute of Physiological Chemistry, University of UlmInstitute of Physiological Chemistry, University of UlmInstitute of Pathology, University Hospital of UlmDepartment of Internal Medicine I, University Hospital of UlmDepartment of Pathology and Molecular Pathology, University Hospital of ZurichInstitute of Physiological Chemistry, University of UlmInstitute of Physiological Chemistry, University of UlmA model of autoimmune pancreatitis is developed by blocking the activation of NF-κB in pancreatic stellate cells, via conditional deletion of NEMO (IKKγ), which presents strong pancreatic inflammation with eosinophilia after the induction of chronic pancreatitis by repeated caerulein challenges.https://doi.org/10.1038/s42003-022-03371-3 |
| spellingShingle | Lap Kwan Chan Miltiadis Tsesmelis Melanie Gerstenlauer Frank Leithäuser Alexander Kleger Lukas Daniel Frick Harald Jacob Maier Thomas Wirth Functional IKK/NF-κB signaling in pancreatic stellate cells is essential to prevent autoimmune pancreatitis Communications Biology |
| title | Functional IKK/NF-κB signaling in pancreatic stellate cells is essential to prevent autoimmune pancreatitis |
| title_full | Functional IKK/NF-κB signaling in pancreatic stellate cells is essential to prevent autoimmune pancreatitis |
| title_fullStr | Functional IKK/NF-κB signaling in pancreatic stellate cells is essential to prevent autoimmune pancreatitis |
| title_full_unstemmed | Functional IKK/NF-κB signaling in pancreatic stellate cells is essential to prevent autoimmune pancreatitis |
| title_short | Functional IKK/NF-κB signaling in pancreatic stellate cells is essential to prevent autoimmune pancreatitis |
| title_sort | functional ikk nf κb signaling in pancreatic stellate cells is essential to prevent autoimmune pancreatitis |
| url | https://doi.org/10.1038/s42003-022-03371-3 |
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