Antidepressants in the Treatment of Functional Dyspepsia: A Systematic Review and Meta-Analysis.
BACKGROUND:Antidepressants have been empirically used in the treatment of functional dyspepsia (FD). However, results from recent clinical trials investigating their efficacy are conflicting. The aim of this study is to evaluate the efficacy of antidepressants in the management of FD in adults. METH...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2016-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4911162?pdf=render |
| _version_ | 1811201978436419584 |
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| author | Yaoyao Lu Meng Chen Zhiyin Huang Chengwei Tang |
| author_facet | Yaoyao Lu Meng Chen Zhiyin Huang Chengwei Tang |
| author_sort | Yaoyao Lu |
| collection | DOAJ |
| description | BACKGROUND:Antidepressants have been empirically used in the treatment of functional dyspepsia (FD). However, results from recent clinical trials investigating their efficacy are conflicting. The aim of this study is to evaluate the efficacy of antidepressants in the management of FD in adults. METHODS:Databases of MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials and BIOSIS Previews were searched for all randomized controlled trials (RCT) investigating efficacy of antidepressants in the management of FD in adult patients. Data of overall symptom unimproved and adverse events were compared between the antidepressants and placebo group. RESULTS:The search strategy identified 432 citations. Of those, eight RCTs met the inclusion criteria and were included in the meta-analysis. The pooled relative risk (RR) of symptom unimproved with tricyclic antidepressants (TCAs) versus placebo was 0.76 (95% CI: 0.62 to 0.94, P = 0.01; I2 = 0%, P = 0.39). By contrast, selective serotonin reuptake inhibitors (SSRIs) did not show a benefit over placebo (RR = 1.00, 95% CI: 0.86 to 1.17, P = 0.95; I2 = 0%, P = 0.82). Adverse events were significantly more frequent among patients receiving antidepressants than those receiving placebos (RR = 1.64, 95% CI: 1.14 to 2.35, P = 0.007). CONCLUSION:TCAs but not SSRIs, are effective in the treatment of FD, but antidepressants were also associated with more adverse events compared with placebo. |
| first_indexed | 2024-04-12T02:30:58Z |
| format | Article |
| id | doaj.art-8018567251264685b8d9a1fe312870bf |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-12T02:30:58Z |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-8018567251264685b8d9a1fe312870bf2022-12-22T03:51:47ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01116e015779810.1371/journal.pone.0157798Antidepressants in the Treatment of Functional Dyspepsia: A Systematic Review and Meta-Analysis.Yaoyao LuMeng ChenZhiyin HuangChengwei TangBACKGROUND:Antidepressants have been empirically used in the treatment of functional dyspepsia (FD). However, results from recent clinical trials investigating their efficacy are conflicting. The aim of this study is to evaluate the efficacy of antidepressants in the management of FD in adults. METHODS:Databases of MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials and BIOSIS Previews were searched for all randomized controlled trials (RCT) investigating efficacy of antidepressants in the management of FD in adult patients. Data of overall symptom unimproved and adverse events were compared between the antidepressants and placebo group. RESULTS:The search strategy identified 432 citations. Of those, eight RCTs met the inclusion criteria and were included in the meta-analysis. The pooled relative risk (RR) of symptom unimproved with tricyclic antidepressants (TCAs) versus placebo was 0.76 (95% CI: 0.62 to 0.94, P = 0.01; I2 = 0%, P = 0.39). By contrast, selective serotonin reuptake inhibitors (SSRIs) did not show a benefit over placebo (RR = 1.00, 95% CI: 0.86 to 1.17, P = 0.95; I2 = 0%, P = 0.82). Adverse events were significantly more frequent among patients receiving antidepressants than those receiving placebos (RR = 1.64, 95% CI: 1.14 to 2.35, P = 0.007). CONCLUSION:TCAs but not SSRIs, are effective in the treatment of FD, but antidepressants were also associated with more adverse events compared with placebo.http://europepmc.org/articles/PMC4911162?pdf=render |
| spellingShingle | Yaoyao Lu Meng Chen Zhiyin Huang Chengwei Tang Antidepressants in the Treatment of Functional Dyspepsia: A Systematic Review and Meta-Analysis. PLoS ONE |
| title | Antidepressants in the Treatment of Functional Dyspepsia: A Systematic Review and Meta-Analysis. |
| title_full | Antidepressants in the Treatment of Functional Dyspepsia: A Systematic Review and Meta-Analysis. |
| title_fullStr | Antidepressants in the Treatment of Functional Dyspepsia: A Systematic Review and Meta-Analysis. |
| title_full_unstemmed | Antidepressants in the Treatment of Functional Dyspepsia: A Systematic Review and Meta-Analysis. |
| title_short | Antidepressants in the Treatment of Functional Dyspepsia: A Systematic Review and Meta-Analysis. |
| title_sort | antidepressants in the treatment of functional dyspepsia a systematic review and meta analysis |
| url | http://europepmc.org/articles/PMC4911162?pdf=render |
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