The Role of Aquaporins in Epileptogenesis—A Systematic Review
Aquaporins (AQPs) are a family of membrane proteins involved in the transport of water and ions across cell membranes. AQPs have been shown to be implicated in various physiological and pathological processes in the brain, including water homeostasis, cell migration, and inflammation, among others....
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-07-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/24/15/11923 |
| _version_ | 1797586744584962048 |
|---|---|
| author | Lapo Bonosi Umberto Emanuele Benigno Sofia Musso Kevin Giardina Rosa Maria Gerardi Lara Brunasso Roberta Costanzo Federica Paolini Felice Buscemi Chiara Avallone Vincenzo Gulino Domenico Gerardo Iacopino Rosario Maugeri |
| author_facet | Lapo Bonosi Umberto Emanuele Benigno Sofia Musso Kevin Giardina Rosa Maria Gerardi Lara Brunasso Roberta Costanzo Federica Paolini Felice Buscemi Chiara Avallone Vincenzo Gulino Domenico Gerardo Iacopino Rosario Maugeri |
| author_sort | Lapo Bonosi |
| collection | DOAJ |
| description | Aquaporins (AQPs) are a family of membrane proteins involved in the transport of water and ions across cell membranes. AQPs have been shown to be implicated in various physiological and pathological processes in the brain, including water homeostasis, cell migration, and inflammation, among others. Epileptogenesis is a complex and multifactorial process that involves alterations in the structure and function of neuronal networks. Recent evidence suggests that AQPs may also play a role in the pathogenesis of epilepsy. In animal models of epilepsy, AQPs have been shown to be upregulated in regions of the brain that are involved in seizure generation, suggesting that they may contribute to the hyperexcitability of neuronal networks. Moreover, genetic studies have identified mutations in AQP genes associated with an increased risk of developing epilepsy. Our review aims to investigate the role of AQPs in epilepsy and seizure onset from a pathophysiological point of view, pointing out the potential molecular mechanism and their clinical implications. |
| first_indexed | 2024-03-11T00:26:32Z |
| format | Article |
| id | doaj.art-8019091b96bc41e0884d4c03368ecdae |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T00:26:32Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-8019091b96bc41e0884d4c03368ecdae2023-11-18T22:57:57ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-07-0124151192310.3390/ijms241511923The Role of Aquaporins in Epileptogenesis—A Systematic ReviewLapo Bonosi0Umberto Emanuele Benigno1Sofia Musso2Kevin Giardina3Rosa Maria Gerardi4Lara Brunasso5Roberta Costanzo6Federica Paolini7Felice Buscemi8Chiara Avallone9Vincenzo Gulino10Domenico Gerardo Iacopino11Rosario Maugeri12Neurosurgical Clinic, AOUP “Paolo Giaccone”, Post Graduate Residency Program in Neurologic Surgery, Department of Biomedicine Neurosciences and Advanced Diagnostics, School of Medicine, University of Palermo, 90127 Palermo, ItalyNeurosurgical Clinic, AOUP “Paolo Giaccone”, Post Graduate Residency Program in Neurologic Surgery, Department of Biomedicine Neurosciences and Advanced Diagnostics, School of Medicine, University of Palermo, 90127 Palermo, ItalyNeurosurgical Clinic, AOUP “Paolo Giaccone”, Post Graduate Residency Program in Neurologic Surgery, Department of Biomedicine Neurosciences and Advanced Diagnostics, School of Medicine, University of Palermo, 90127 Palermo, ItalyNeurosurgical Clinic, AOUP “Paolo Giaccone”, Post Graduate Residency Program in Neurologic Surgery, Department of Biomedicine Neurosciences and Advanced Diagnostics, School of Medicine, University of Palermo, 90127 Palermo, ItalyNeurosurgical Clinic, AOUP “Paolo Giaccone”, Post Graduate Residency Program in Neurologic Surgery, Department of Biomedicine Neurosciences and Advanced Diagnostics, School of Medicine, University of Palermo, 90127 Palermo, ItalyNeurosurgical Clinic, AOUP “Paolo Giaccone”, Post Graduate Residency Program in Neurologic Surgery, Department of Biomedicine Neurosciences and Advanced Diagnostics, School of Medicine, University of Palermo, 90127 Palermo, ItalyNeurosurgical Clinic, AOUP “Paolo Giaccone”, Post Graduate Residency Program in Neurologic Surgery, Department of Biomedicine Neurosciences and Advanced Diagnostics, School of Medicine, University of Palermo, 90127 Palermo, ItalyNeurosurgical Clinic, AOUP “Paolo Giaccone”, Post Graduate Residency Program in Neurologic Surgery, Department of Biomedicine Neurosciences and Advanced Diagnostics, School of Medicine, University of Palermo, 90127 Palermo, ItalyNeurosurgical Clinic, AOUP “Paolo Giaccone”, Post Graduate Residency Program in Neurologic Surgery, Department of Biomedicine Neurosciences and Advanced Diagnostics, School of Medicine, University of Palermo, 90127 Palermo, ItalyNeurosurgical Clinic, AOUP “Paolo Giaccone”, Post Graduate Residency Program in Neurologic Surgery, Department of Biomedicine Neurosciences and Advanced Diagnostics, School of Medicine, University of Palermo, 90127 Palermo, ItalyNeurosurgical Clinic, AOUP “Paolo Giaccone”, Post Graduate Residency Program in Neurologic Surgery, Department of Biomedicine Neurosciences and Advanced Diagnostics, School of Medicine, University of Palermo, 90127 Palermo, ItalyNeurosurgical Clinic, AOUP “Paolo Giaccone”, Post Graduate Residency Program in Neurologic Surgery, Department of Biomedicine Neurosciences and Advanced Diagnostics, School of Medicine, University of Palermo, 90127 Palermo, ItalyNeurosurgical Clinic, AOUP “Paolo Giaccone”, Post Graduate Residency Program in Neurologic Surgery, Department of Biomedicine Neurosciences and Advanced Diagnostics, School of Medicine, University of Palermo, 90127 Palermo, ItalyAquaporins (AQPs) are a family of membrane proteins involved in the transport of water and ions across cell membranes. AQPs have been shown to be implicated in various physiological and pathological processes in the brain, including water homeostasis, cell migration, and inflammation, among others. Epileptogenesis is a complex and multifactorial process that involves alterations in the structure and function of neuronal networks. Recent evidence suggests that AQPs may also play a role in the pathogenesis of epilepsy. In animal models of epilepsy, AQPs have been shown to be upregulated in regions of the brain that are involved in seizure generation, suggesting that they may contribute to the hyperexcitability of neuronal networks. Moreover, genetic studies have identified mutations in AQP genes associated with an increased risk of developing epilepsy. Our review aims to investigate the role of AQPs in epilepsy and seizure onset from a pathophysiological point of view, pointing out the potential molecular mechanism and their clinical implications.https://www.mdpi.com/1422-0067/24/15/11923aquaporinsAQP4epilepsyseizureion homeostasispathophysiology |
| spellingShingle | Lapo Bonosi Umberto Emanuele Benigno Sofia Musso Kevin Giardina Rosa Maria Gerardi Lara Brunasso Roberta Costanzo Federica Paolini Felice Buscemi Chiara Avallone Vincenzo Gulino Domenico Gerardo Iacopino Rosario Maugeri The Role of Aquaporins in Epileptogenesis—A Systematic Review International Journal of Molecular Sciences aquaporins AQP4 epilepsy seizure ion homeostasis pathophysiology |
| title | The Role of Aquaporins in Epileptogenesis—A Systematic Review |
| title_full | The Role of Aquaporins in Epileptogenesis—A Systematic Review |
| title_fullStr | The Role of Aquaporins in Epileptogenesis—A Systematic Review |
| title_full_unstemmed | The Role of Aquaporins in Epileptogenesis—A Systematic Review |
| title_short | The Role of Aquaporins in Epileptogenesis—A Systematic Review |
| title_sort | role of aquaporins in epileptogenesis a systematic review |
| topic | aquaporins AQP4 epilepsy seizure ion homeostasis pathophysiology |
| url | https://www.mdpi.com/1422-0067/24/15/11923 |
| work_keys_str_mv | AT lapobonosi theroleofaquaporinsinepileptogenesisasystematicreview AT umbertoemanuelebenigno theroleofaquaporinsinepileptogenesisasystematicreview AT sofiamusso theroleofaquaporinsinepileptogenesisasystematicreview AT kevingiardina theroleofaquaporinsinepileptogenesisasystematicreview AT rosamariagerardi theroleofaquaporinsinepileptogenesisasystematicreview AT larabrunasso theroleofaquaporinsinepileptogenesisasystematicreview AT robertacostanzo theroleofaquaporinsinepileptogenesisasystematicreview AT federicapaolini theroleofaquaporinsinepileptogenesisasystematicreview AT felicebuscemi theroleofaquaporinsinepileptogenesisasystematicreview AT chiaraavallone theroleofaquaporinsinepileptogenesisasystematicreview AT vincenzogulino theroleofaquaporinsinepileptogenesisasystematicreview AT domenicogerardoiacopino theroleofaquaporinsinepileptogenesisasystematicreview AT rosariomaugeri theroleofaquaporinsinepileptogenesisasystematicreview AT lapobonosi roleofaquaporinsinepileptogenesisasystematicreview AT umbertoemanuelebenigno roleofaquaporinsinepileptogenesisasystematicreview AT sofiamusso roleofaquaporinsinepileptogenesisasystematicreview AT kevingiardina roleofaquaporinsinepileptogenesisasystematicreview AT rosamariagerardi roleofaquaporinsinepileptogenesisasystematicreview AT larabrunasso roleofaquaporinsinepileptogenesisasystematicreview AT robertacostanzo roleofaquaporinsinepileptogenesisasystematicreview AT federicapaolini roleofaquaporinsinepileptogenesisasystematicreview AT felicebuscemi roleofaquaporinsinepileptogenesisasystematicreview AT chiaraavallone roleofaquaporinsinepileptogenesisasystematicreview AT vincenzogulino roleofaquaporinsinepileptogenesisasystematicreview AT domenicogerardoiacopino roleofaquaporinsinepileptogenesisasystematicreview AT rosariomaugeri roleofaquaporinsinepileptogenesisasystematicreview |