Stochastic modelling, Bayesian inference, and new in vivo measurements elucidate the debated mtDNA bottleneck mechanism

Stochastic modelling, Bayesian inference, and new in vivo measurements elucidate the debated mtDNA bottleneck mechanism

Dangerous damage to mitochondrial DNA (mtDNA) can be ameliorated during mammalian development through a highly debated mechanism called the mtDNA bottleneck. Uncertainty surrounding this process limits our ability to address inherited mtDNA diseases. We produce a new, physically motivated, generalis...

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Bibliographic Details
Main Authors: Iain G Johnston, Joerg P Burgstaller, Vitezslav Havlicek, Thomas Kolbe, Thomas Rülicke, Gottfried Brem, Jo Poulton, Nick S Jones
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-06-01
Series:eLife
Subjects:
mtDNA
bottleneck
stochastic modelling
developmental biology
statistic
Online Access:https://elifesciences.org/articles/07464

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