DNA Sensor IFI204 Contributes to Host Defense Against Staphylococcus aureus Infection in Mice

DNA Sensor IFI204 Contributes to Host Defense Against Staphylococcus aureus Infection in Mice

Interferon-inducible protein (IFI204) (p204, the murine homolog of human IFI16) is known as a cytosolic DNA sensor to recognize DNA viruses and intracellular bacteria. However, little is known about its role during extracellular bacterial infection. Here we show that IFI204 is required for host defe...

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Bibliographic Details
Main Authors: Wei Chen, Shui-Xing Yu, Feng-Hua Zhou, Xiao-Jing Zhang, Wen-Ying Gao, Kun-Yu Li, Zhen-Zhen Liu, Wen-Yu Han, Yong-Jun Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Immunology
Subjects:
Staphylococcus aureus (MRSA)
IFI204
DNA sensor
STING
IFI16
innate immune
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00474/full

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