A sexually dimorphic pre-stressed translational signature in CA3 pyramidal neurons of BDNF Val66Met mice
Animals’ response to acute stress is known to be influenced by sex and genetics. Here the authors performed RNA-seq on actively translated mRNAs in hippocampal CA3 neurons in mice, and document the effects of sex and genotype (i.e., BDNF Val66Met) on acute stress-induced gene expression.
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2017-10-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-01014-4 |
| _version_ | 1818421386660544512 |
|---|---|
| author | Jordan Marrocco Gordon H. Petty Mariel B. Ríos Jason D. Gray Joshua F. Kogan Elizabeth M. Waters Eric F. Schmidt Francis S. Lee Bruce S. McEwen |
| author_facet | Jordan Marrocco Gordon H. Petty Mariel B. Ríos Jason D. Gray Joshua F. Kogan Elizabeth M. Waters Eric F. Schmidt Francis S. Lee Bruce S. McEwen |
| author_sort | Jordan Marrocco |
| collection | DOAJ |
| description | Animals’ response to acute stress is known to be influenced by sex and genetics. Here the authors performed RNA-seq on actively translated mRNAs in hippocampal CA3 neurons in mice, and document the effects of sex and genotype (i.e., BDNF Val66Met) on acute stress-induced gene expression. |
| first_indexed | 2024-12-14T13:09:32Z |
| format | Article |
| id | doaj.art-801b66d7a1be477d9f8b4a7aaf7b868e |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T13:09:32Z |
| publishDate | 2017-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-801b66d7a1be477d9f8b4a7aaf7b868e2022-12-21T23:00:13ZengNature PortfolioNature Communications2041-17232017-10-018111510.1038/s41467-017-01014-4A sexually dimorphic pre-stressed translational signature in CA3 pyramidal neurons of BDNF Val66Met miceJordan Marrocco0Gordon H. Petty1Mariel B. Ríos2Jason D. Gray3Joshua F. Kogan4Elizabeth M. Waters5Eric F. Schmidt6Francis S. Lee7Bruce S. McEwen8Laboratory of Neuroendocrinology, The Rockefeller UniversityLaboratory of Neuroendocrinology, The Rockefeller UniversityLaboratory of Neuroendocrinology, The Rockefeller UniversityLaboratory of Neuroendocrinology, The Rockefeller UniversityLaboratory of Neuroendocrinology, The Rockefeller UniversityLaboratory of Neuroendocrinology, The Rockefeller UniversityLaboratory of Molecular Biology, The Rockefeller UniversitySackler Institute for Developmental Psychobiology, Department of Psychiatry, Weill Cornell Medical CollegeLaboratory of Neuroendocrinology, The Rockefeller UniversityAnimals’ response to acute stress is known to be influenced by sex and genetics. Here the authors performed RNA-seq on actively translated mRNAs in hippocampal CA3 neurons in mice, and document the effects of sex and genotype (i.e., BDNF Val66Met) on acute stress-induced gene expression.https://doi.org/10.1038/s41467-017-01014-4 |
| spellingShingle | Jordan Marrocco Gordon H. Petty Mariel B. Ríos Jason D. Gray Joshua F. Kogan Elizabeth M. Waters Eric F. Schmidt Francis S. Lee Bruce S. McEwen A sexually dimorphic pre-stressed translational signature in CA3 pyramidal neurons of BDNF Val66Met mice Nature Communications |
| title | A sexually dimorphic pre-stressed translational signature in CA3 pyramidal neurons of BDNF Val66Met mice |
| title_full | A sexually dimorphic pre-stressed translational signature in CA3 pyramidal neurons of BDNF Val66Met mice |
| title_fullStr | A sexually dimorphic pre-stressed translational signature in CA3 pyramidal neurons of BDNF Val66Met mice |
| title_full_unstemmed | A sexually dimorphic pre-stressed translational signature in CA3 pyramidal neurons of BDNF Val66Met mice |
| title_short | A sexually dimorphic pre-stressed translational signature in CA3 pyramidal neurons of BDNF Val66Met mice |
| title_sort | sexually dimorphic pre stressed translational signature in ca3 pyramidal neurons of bdnf val66met mice |
| url | https://doi.org/10.1038/s41467-017-01014-4 |
| work_keys_str_mv | AT jordanmarrocco asexuallydimorphicprestressedtranslationalsignatureinca3pyramidalneuronsofbdnfval66metmice AT gordonhpetty asexuallydimorphicprestressedtranslationalsignatureinca3pyramidalneuronsofbdnfval66metmice AT marielbrios asexuallydimorphicprestressedtranslationalsignatureinca3pyramidalneuronsofbdnfval66metmice AT jasondgray asexuallydimorphicprestressedtranslationalsignatureinca3pyramidalneuronsofbdnfval66metmice AT joshuafkogan asexuallydimorphicprestressedtranslationalsignatureinca3pyramidalneuronsofbdnfval66metmice AT elizabethmwaters asexuallydimorphicprestressedtranslationalsignatureinca3pyramidalneuronsofbdnfval66metmice AT ericfschmidt asexuallydimorphicprestressedtranslationalsignatureinca3pyramidalneuronsofbdnfval66metmice AT francisslee asexuallydimorphicprestressedtranslationalsignatureinca3pyramidalneuronsofbdnfval66metmice AT brucesmcewen asexuallydimorphicprestressedtranslationalsignatureinca3pyramidalneuronsofbdnfval66metmice AT jordanmarrocco sexuallydimorphicprestressedtranslationalsignatureinca3pyramidalneuronsofbdnfval66metmice AT gordonhpetty sexuallydimorphicprestressedtranslationalsignatureinca3pyramidalneuronsofbdnfval66metmice AT marielbrios sexuallydimorphicprestressedtranslationalsignatureinca3pyramidalneuronsofbdnfval66metmice AT jasondgray sexuallydimorphicprestressedtranslationalsignatureinca3pyramidalneuronsofbdnfval66metmice AT joshuafkogan sexuallydimorphicprestressedtranslationalsignatureinca3pyramidalneuronsofbdnfval66metmice AT elizabethmwaters sexuallydimorphicprestressedtranslationalsignatureinca3pyramidalneuronsofbdnfval66metmice AT ericfschmidt sexuallydimorphicprestressedtranslationalsignatureinca3pyramidalneuronsofbdnfval66metmice AT francisslee sexuallydimorphicprestressedtranslationalsignatureinca3pyramidalneuronsofbdnfval66metmice AT brucesmcewen sexuallydimorphicprestressedtranslationalsignatureinca3pyramidalneuronsofbdnfval66metmice |