Relationship of sarcopenia with steatohepatitis and advanced liver fibrosis in non-alcoholic fatty liver disease: a meta-analysis
Abstract Background Several studies have emerged indicating that sarcopenia is associated with nonalcoholic fatty liver disease, we aimed to systematically review and quantify the association between sacropenia and the histological severity of nonalcoholic fatty liver disease. Methods Pubmed, the Co...
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| Format: | Article |
| Language: | English |
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BMC
2018-04-01
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| Series: | BMC Gastroenterology |
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| Online Access: | http://link.springer.com/article/10.1186/s12876-018-0776-0 |
| _version_ | 1818503092565442560 |
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| author | Rui Yu Qiangwei Shi Lei Liu Lidong Chen |
| author_facet | Rui Yu Qiangwei Shi Lei Liu Lidong Chen |
| author_sort | Rui Yu |
| collection | DOAJ |
| description | Abstract Background Several studies have emerged indicating that sarcopenia is associated with nonalcoholic fatty liver disease, we aimed to systematically review and quantify the association between sacropenia and the histological severity of nonalcoholic fatty liver disease. Methods Pubmed, the Cochrane Library and EMBASE were searched (until August 2017) for studies examining the relationship of sarcopenia with steatohepatitis and advanced liver fibrosis in nonalcoholic fatty liver disease. Pooled odds ratios were estimated by fixed effects models. Results Three articles met our inclusion criteria, with a total of 3226 individuals. Two of the studies examined the association between sacropenia and steatohepatitis, a significant association was documented between sarcopenia and steatohepatitis (OR = 2.35, 95%CI 1.45, 3.81). All of the three studies assessed the association between sacropenia and advanced liver fibrosis, a significant association between sarcopenia and advanced liver fibrosis (OR = 2.41, 95%CI 1.94, 2.98). No significant heterogeneity was detected among studies in all comparisons. These results remained essentially unchanged after excluding any of the studies in the sensitivity analysis. Conclusions Sarcopenia in patients with nonalcoholic fatty liver disease is associated with a higher likelihood of having steatohepatitis or advanced liver fibrosis. Demonstration of the role of sarcopenia in nonalcoholic fatty liver disease development in future studies could have important therapeutic implications. |
| first_indexed | 2024-12-10T21:19:23Z |
| format | Article |
| id | doaj.art-801c29202a0e4857a69e5aa2a2a9ab6b |
| institution | Directory Open Access Journal |
| issn | 1471-230X |
| language | English |
| last_indexed | 2024-12-10T21:19:23Z |
| publishDate | 2018-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj.art-801c29202a0e4857a69e5aa2a2a9ab6b2022-12-22T01:33:11ZengBMCBMC Gastroenterology1471-230X2018-04-011811610.1186/s12876-018-0776-0Relationship of sarcopenia with steatohepatitis and advanced liver fibrosis in non-alcoholic fatty liver disease: a meta-analysisRui Yu0Qiangwei Shi1Lei Liu2Lidong Chen3Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou UniversityDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou UniversityDepartment of Nasology, The First Affiliated Hospital of Zhengzhou UniversityDepartment of Gastroenterology, The First Affiliated Hospital of Zhengzhou UniversityAbstract Background Several studies have emerged indicating that sarcopenia is associated with nonalcoholic fatty liver disease, we aimed to systematically review and quantify the association between sacropenia and the histological severity of nonalcoholic fatty liver disease. Methods Pubmed, the Cochrane Library and EMBASE were searched (until August 2017) for studies examining the relationship of sarcopenia with steatohepatitis and advanced liver fibrosis in nonalcoholic fatty liver disease. Pooled odds ratios were estimated by fixed effects models. Results Three articles met our inclusion criteria, with a total of 3226 individuals. Two of the studies examined the association between sacropenia and steatohepatitis, a significant association was documented between sarcopenia and steatohepatitis (OR = 2.35, 95%CI 1.45, 3.81). All of the three studies assessed the association between sacropenia and advanced liver fibrosis, a significant association between sarcopenia and advanced liver fibrosis (OR = 2.41, 95%CI 1.94, 2.98). No significant heterogeneity was detected among studies in all comparisons. These results remained essentially unchanged after excluding any of the studies in the sensitivity analysis. Conclusions Sarcopenia in patients with nonalcoholic fatty liver disease is associated with a higher likelihood of having steatohepatitis or advanced liver fibrosis. Demonstration of the role of sarcopenia in nonalcoholic fatty liver disease development in future studies could have important therapeutic implications.http://link.springer.com/article/10.1186/s12876-018-0776-0SarcopeniaNonalcoholic fatty liver diseaseMeta-analysisSteatohepatitisLiver fibrosis |
| spellingShingle | Rui Yu Qiangwei Shi Lei Liu Lidong Chen Relationship of sarcopenia with steatohepatitis and advanced liver fibrosis in non-alcoholic fatty liver disease: a meta-analysis BMC Gastroenterology Sarcopenia Nonalcoholic fatty liver disease Meta-analysis Steatohepatitis Liver fibrosis |
| title | Relationship of sarcopenia with steatohepatitis and advanced liver fibrosis in non-alcoholic fatty liver disease: a meta-analysis |
| title_full | Relationship of sarcopenia with steatohepatitis and advanced liver fibrosis in non-alcoholic fatty liver disease: a meta-analysis |
| title_fullStr | Relationship of sarcopenia with steatohepatitis and advanced liver fibrosis in non-alcoholic fatty liver disease: a meta-analysis |
| title_full_unstemmed | Relationship of sarcopenia with steatohepatitis and advanced liver fibrosis in non-alcoholic fatty liver disease: a meta-analysis |
| title_short | Relationship of sarcopenia with steatohepatitis and advanced liver fibrosis in non-alcoholic fatty liver disease: a meta-analysis |
| title_sort | relationship of sarcopenia with steatohepatitis and advanced liver fibrosis in non alcoholic fatty liver disease a meta analysis |
| topic | Sarcopenia Nonalcoholic fatty liver disease Meta-analysis Steatohepatitis Liver fibrosis |
| url | http://link.springer.com/article/10.1186/s12876-018-0776-0 |
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