Inhibitory effects of NSAID-conjugated SN-38 on the viability of A549 Non-small cell lung cancer cells
The goal of this paper was to look into the anti-tumor mechanism of Non-Steroidal Anti-Inflammatory Drug (NSAID)-conjugated SN-38 Prodrug in A549 lung cancer cells. We found that Indomethacine–SN–38 (IndoSN-38) and Naproxen–SN–38(NaproSN-38) as a theranostic prodrug targeting cyclooxygenase-2(COX-2)...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | Biochemistry and Biophysics Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405580823000985 |
| _version_ | 1797660315423342592 |
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| author | Hae–Won Kwon Jusung An Jong Seung Kim In-Cheol Kang |
| author_facet | Hae–Won Kwon Jusung An Jong Seung Kim In-Cheol Kang |
| author_sort | Hae–Won Kwon |
| collection | DOAJ |
| description | The goal of this paper was to look into the anti-tumor mechanism of Non-Steroidal Anti-Inflammatory Drug (NSAID)-conjugated SN-38 Prodrug in A549 lung cancer cells. We found that Indomethacine–SN–38 (IndoSN-38) and Naproxen–SN–38(NaproSN-38) as a theranostic prodrug targeting cyclooxygenase-2(COX-2) in cancer cells inhibited A549 cell viability in a dose-dependent fashion. IndoSN-38 and NaproSN-38 inhibited A549 cell viability in a dose-dependent fashion. The suppression of A549 cell viability was due to induction of the cell apoptosis by enhancing the activities of Caspase 3 and Caspase 8. The cell cycle arrest of sub-G1 was found in the cells treated with IndoSN-38 or NaproSN-38. Collectively, these data suggested that the anti-proliferative activities of the NSAID-conjugated SN-38 prodrugs were due to promotion of cell death and arresting the cell cycle which was similar with those of SN-38. |
| first_indexed | 2024-03-11T18:27:59Z |
| format | Article |
| id | doaj.art-801c7774023a48dbb21fb9c98e66e9dd |
| institution | Directory Open Access Journal |
| issn | 2405-5808 |
| language | English |
| last_indexed | 2024-03-11T18:27:59Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biochemistry and Biophysics Reports |
| spelling | doaj.art-801c7774023a48dbb21fb9c98e66e9dd2023-10-13T13:54:56ZengElsevierBiochemistry and Biophysics Reports2405-58082023-09-0135101517Inhibitory effects of NSAID-conjugated SN-38 on the viability of A549 Non-small cell lung cancer cellsHae–Won Kwon0Jusung An1Jong Seung Kim2In-Cheol Kang3Department of Bioconvergence System, Graduate School, and BioChip Research Center, Hoseo University, Asan, 336-795, South KoreaDepartment of Chemistry, Korea University, Seoul, 02841, South KoreaDepartment of Chemistry, Korea University, Seoul, 02841, South Korea; Corresponding author. Department of Chemistry, Korea University, Seoul, 02841, Republic of Korea.Department of Bioconvergence System, Graduate School, and BioChip Research Center, Hoseo University, Asan, 336-795, South Korea; InnoPharmaScreen Inc, Incheon, 21988, South Korea; Corresponding author. Department of Bioconvergence system, Graduate school, and BioChip Research Center, Hoseo University, Asan 336-795, Republic of Korea.The goal of this paper was to look into the anti-tumor mechanism of Non-Steroidal Anti-Inflammatory Drug (NSAID)-conjugated SN-38 Prodrug in A549 lung cancer cells. We found that Indomethacine–SN–38 (IndoSN-38) and Naproxen–SN–38(NaproSN-38) as a theranostic prodrug targeting cyclooxygenase-2(COX-2) in cancer cells inhibited A549 cell viability in a dose-dependent fashion. IndoSN-38 and NaproSN-38 inhibited A549 cell viability in a dose-dependent fashion. The suppression of A549 cell viability was due to induction of the cell apoptosis by enhancing the activities of Caspase 3 and Caspase 8. The cell cycle arrest of sub-G1 was found in the cells treated with IndoSN-38 or NaproSN-38. Collectively, these data suggested that the anti-proliferative activities of the NSAID-conjugated SN-38 prodrugs were due to promotion of cell death and arresting the cell cycle which was similar with those of SN-38.http://www.sciencedirect.com/science/article/pii/S2405580823000985IndoSN-38NaproSN-38A549 cellsLung cancer |
| spellingShingle | Hae–Won Kwon Jusung An Jong Seung Kim In-Cheol Kang Inhibitory effects of NSAID-conjugated SN-38 on the viability of A549 Non-small cell lung cancer cells Biochemistry and Biophysics Reports IndoSN-38 NaproSN-38 A549 cells Lung cancer |
| title | Inhibitory effects of NSAID-conjugated SN-38 on the viability of A549 Non-small cell lung cancer cells |
| title_full | Inhibitory effects of NSAID-conjugated SN-38 on the viability of A549 Non-small cell lung cancer cells |
| title_fullStr | Inhibitory effects of NSAID-conjugated SN-38 on the viability of A549 Non-small cell lung cancer cells |
| title_full_unstemmed | Inhibitory effects of NSAID-conjugated SN-38 on the viability of A549 Non-small cell lung cancer cells |
| title_short | Inhibitory effects of NSAID-conjugated SN-38 on the viability of A549 Non-small cell lung cancer cells |
| title_sort | inhibitory effects of nsaid conjugated sn 38 on the viability of a549 non small cell lung cancer cells |
| topic | IndoSN-38 NaproSN-38 A549 cells Lung cancer |
| url | http://www.sciencedirect.com/science/article/pii/S2405580823000985 |
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