Roles of NAD(P)H:quinone Oxidoreductase 1 in Diverse Diseases
NAD(P)H:quinone oxidoreductase (NQO) is an antioxidant flavoprotein that catalyzes the reduction of highly reactive quinone metabolites by employing NAD(P)H as an electron donor. There are two NQO enzymes—NQO1 and NQO2—in mammalian systems. In particular, NQO1 exerts many biological activities, incl...
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| Format: | Article |
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MDPI AG
2021-11-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/11/12/1301 |
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| author | Wang-Soo Lee Woojin Ham Jaetaek Kim |
| author_facet | Wang-Soo Lee Woojin Ham Jaetaek Kim |
| author_sort | Wang-Soo Lee |
| collection | DOAJ |
| description | NAD(P)H:quinone oxidoreductase (NQO) is an antioxidant flavoprotein that catalyzes the reduction of highly reactive quinone metabolites by employing NAD(P)H as an electron donor. There are two NQO enzymes—NQO1 and NQO2—in mammalian systems. In particular, NQO1 exerts many biological activities, including antioxidant activities, anti-inflammatory effects, and interactions with tumor suppressors. Moreover, several recent studies have revealed the promising roles of NQO1 in protecting against cardiovascular damage and related diseases, such as dyslipidemia, atherosclerosis, insulin resistance, and metabolic syndrome. In this review, we discuss recent developments in the molecular regulation and biochemical properties of NQO1, and describe the potential beneficial roles of NQO1 in diseases associated with oxidative stress. |
| first_indexed | 2024-03-10T03:44:00Z |
| format | Article |
| id | doaj.art-801c919e2c3b4367bccedf05d39b203e |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-10T03:44:00Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-801c919e2c3b4367bccedf05d39b203e2023-11-23T09:13:28ZengMDPI AGLife2075-17292021-11-011112130110.3390/life11121301Roles of NAD(P)H:quinone Oxidoreductase 1 in Diverse DiseasesWang-Soo Lee0Woojin Ham1Jaetaek Kim2Division of Cardiology, Department of Internal Medicine, College of Medicine, Chung-Ang University, Seoul 06974, KoreaDivision of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, Chung-Ang University, Seoul 06974, KoreaDivision of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, Chung-Ang University, Seoul 06974, KoreaNAD(P)H:quinone oxidoreductase (NQO) is an antioxidant flavoprotein that catalyzes the reduction of highly reactive quinone metabolites by employing NAD(P)H as an electron donor. There are two NQO enzymes—NQO1 and NQO2—in mammalian systems. In particular, NQO1 exerts many biological activities, including antioxidant activities, anti-inflammatory effects, and interactions with tumor suppressors. Moreover, several recent studies have revealed the promising roles of NQO1 in protecting against cardiovascular damage and related diseases, such as dyslipidemia, atherosclerosis, insulin resistance, and metabolic syndrome. In this review, we discuss recent developments in the molecular regulation and biochemical properties of NQO1, and describe the potential beneficial roles of NQO1 in diseases associated with oxidative stress.https://www.mdpi.com/2075-1729/11/12/1301NAD(P)H:quinone oxidoreductase 1oxidative stresshuman diseases |
| spellingShingle | Wang-Soo Lee Woojin Ham Jaetaek Kim Roles of NAD(P)H:quinone Oxidoreductase 1 in Diverse Diseases Life NAD(P)H:quinone oxidoreductase 1 oxidative stress human diseases |
| title | Roles of NAD(P)H:quinone Oxidoreductase 1 in Diverse Diseases |
| title_full | Roles of NAD(P)H:quinone Oxidoreductase 1 in Diverse Diseases |
| title_fullStr | Roles of NAD(P)H:quinone Oxidoreductase 1 in Diverse Diseases |
| title_full_unstemmed | Roles of NAD(P)H:quinone Oxidoreductase 1 in Diverse Diseases |
| title_short | Roles of NAD(P)H:quinone Oxidoreductase 1 in Diverse Diseases |
| title_sort | roles of nad p h quinone oxidoreductase 1 in diverse diseases |
| topic | NAD(P)H:quinone oxidoreductase 1 oxidative stress human diseases |
| url | https://www.mdpi.com/2075-1729/11/12/1301 |
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