Association Between Factors Involved in Bone Remodeling (Osteoactivin and OPG) With Plasma Levels of Irisin and Meteorin-Like Protein in People With T2D and Obesity
The musculoskeletal system consisting of bones and muscles have been recognized as endocrine organs secreting hormones that are involved in regulating metabolic and inflammatory pathways. Obesity and type 2 diabetes (T2D) are associated with several musculoskeletal system complications. We hypothesi...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-10-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2021.752892/full |
| _version_ | 1819001611586895872 |
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| author | Preethi Cherian Irina Al-Khairi Mohammad Jamal Suleiman Al-Sabah Hamad Ali Carol Dsouza Eman Alshawaf Waleed Al-Ali Ghanim Al-Khaledi Fahd Al-Mulla Mohamed Abu-Farha Jehad Abubaker |
| author_facet | Preethi Cherian Irina Al-Khairi Mohammad Jamal Suleiman Al-Sabah Hamad Ali Carol Dsouza Eman Alshawaf Waleed Al-Ali Ghanim Al-Khaledi Fahd Al-Mulla Mohamed Abu-Farha Jehad Abubaker |
| author_sort | Preethi Cherian |
| collection | DOAJ |
| description | The musculoskeletal system consisting of bones and muscles have been recognized as endocrine organs secreting hormones that are involved in regulating metabolic and inflammatory pathways. Obesity and type 2 diabetes (T2D) are associated with several musculoskeletal system complications. We hypothesized that an interaction exists between adipomyokines namely, irisin and METRNL, and various molecules involved in bone remodeling in individuals with obesity and T2D. A total of 228 individuals were enrolled in this study, including 124 non-diabetic (ND) and 104 T2D. A Multiplex assay was used to assess the level of various osteogenic molecules namely osteoactivin, Syndecan, osteoprotegerin (OPG) and osteonectin/SPARC. Our data shows elevated levels of Osteoactivin, Syndecan, OPG and SPARC in T2D as compared to ND individuals (p ≤ 0.05). Using Spearman’s correlation, a positive correlation was observed between irisin and Osteoactivin as well as OPG (p < 0.05). Similarly, a positive association was observed between METRNL and Osteoactivin (p < 0.05). The strong positive association shown in this study between irisin, METRNL and various molecules with osteogenic properties emphasize a possible interaction between these organs. This report suggests that having a dysregulation in the level of the aforementioned molecules could potentially affect the development of bone and muscle related complications that are associated with obesity and T2D. |
| first_indexed | 2024-12-20T22:51:58Z |
| format | Article |
| id | doaj.art-801e062f03364aa685dfe737d841047b |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-20T22:51:58Z |
| publishDate | 2021-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-801e062f03364aa685dfe737d841047b2022-12-21T19:24:13ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922021-10-011210.3389/fendo.2021.752892752892Association Between Factors Involved in Bone Remodeling (Osteoactivin and OPG) With Plasma Levels of Irisin and Meteorin-Like Protein in People With T2D and ObesityPreethi Cherian0Irina Al-Khairi1Mohammad Jamal2Suleiman Al-Sabah3Hamad Ali4Carol Dsouza5Eman Alshawaf6Waleed Al-Ali7Ghanim Al-Khaledi8Fahd Al-Mulla9Mohamed Abu-Farha10Jehad Abubaker11Department of Biochemistry and Molecular Biology, Dasman Diabetes Institute, Kuwait City, KuwaitDepartment of Biochemistry and Molecular Biology, Dasman Diabetes Institute, Kuwait City, KuwaitDepartment of Surgery, Faculty of Medicine, Health Sciences Centre, Kuwait University, Sulaibekhat, KuwaitDepartment of Pharmacology & Toxicology, Faculty of Medicine, Kuwait University, Safat, KuwaitDepartment of Genetic and Bioinformatics, Dasman Diabetes Institute, Kuwait City, KuwaitDepartment of Surgery, Faculty of Medicine, Health Sciences Centre, Kuwait University, Sulaibekhat, KuwaitDepartment of Biochemistry and Molecular Biology, Dasman Diabetes Institute, Kuwait City, KuwaitDepartment of Surgery, Faculty of Medicine, Health Sciences Centre, Kuwait University, Sulaibekhat, KuwaitDepartment of Pharmacology & Toxicology, Faculty of Medicine, Kuwait University, Safat, KuwaitDepartment of Genetic and Bioinformatics, Dasman Diabetes Institute, Kuwait City, KuwaitDepartment of Biochemistry and Molecular Biology, Dasman Diabetes Institute, Kuwait City, KuwaitDepartment of Biochemistry and Molecular Biology, Dasman Diabetes Institute, Kuwait City, KuwaitThe musculoskeletal system consisting of bones and muscles have been recognized as endocrine organs secreting hormones that are involved in regulating metabolic and inflammatory pathways. Obesity and type 2 diabetes (T2D) are associated with several musculoskeletal system complications. We hypothesized that an interaction exists between adipomyokines namely, irisin and METRNL, and various molecules involved in bone remodeling in individuals with obesity and T2D. A total of 228 individuals were enrolled in this study, including 124 non-diabetic (ND) and 104 T2D. A Multiplex assay was used to assess the level of various osteogenic molecules namely osteoactivin, Syndecan, osteoprotegerin (OPG) and osteonectin/SPARC. Our data shows elevated levels of Osteoactivin, Syndecan, OPG and SPARC in T2D as compared to ND individuals (p ≤ 0.05). Using Spearman’s correlation, a positive correlation was observed between irisin and Osteoactivin as well as OPG (p < 0.05). Similarly, a positive association was observed between METRNL and Osteoactivin (p < 0.05). The strong positive association shown in this study between irisin, METRNL and various molecules with osteogenic properties emphasize a possible interaction between these organs. This report suggests that having a dysregulation in the level of the aforementioned molecules could potentially affect the development of bone and muscle related complications that are associated with obesity and T2D.https://www.frontiersin.org/articles/10.3389/fendo.2021.752892/fullosteoactivinOPGirisinmeteorin-like proteinSPARCsyndecan-4 |
| spellingShingle | Preethi Cherian Irina Al-Khairi Mohammad Jamal Suleiman Al-Sabah Hamad Ali Carol Dsouza Eman Alshawaf Waleed Al-Ali Ghanim Al-Khaledi Fahd Al-Mulla Mohamed Abu-Farha Jehad Abubaker Association Between Factors Involved in Bone Remodeling (Osteoactivin and OPG) With Plasma Levels of Irisin and Meteorin-Like Protein in People With T2D and Obesity Frontiers in Endocrinology osteoactivin OPG irisin meteorin-like protein SPARC syndecan-4 |
| title | Association Between Factors Involved in Bone Remodeling (Osteoactivin and OPG) With Plasma Levels of Irisin and Meteorin-Like Protein in People With T2D and Obesity |
| title_full | Association Between Factors Involved in Bone Remodeling (Osteoactivin and OPG) With Plasma Levels of Irisin and Meteorin-Like Protein in People With T2D and Obesity |
| title_fullStr | Association Between Factors Involved in Bone Remodeling (Osteoactivin and OPG) With Plasma Levels of Irisin and Meteorin-Like Protein in People With T2D and Obesity |
| title_full_unstemmed | Association Between Factors Involved in Bone Remodeling (Osteoactivin and OPG) With Plasma Levels of Irisin and Meteorin-Like Protein in People With T2D and Obesity |
| title_short | Association Between Factors Involved in Bone Remodeling (Osteoactivin and OPG) With Plasma Levels of Irisin and Meteorin-Like Protein in People With T2D and Obesity |
| title_sort | association between factors involved in bone remodeling osteoactivin and opg with plasma levels of irisin and meteorin like protein in people with t2d and obesity |
| topic | osteoactivin OPG irisin meteorin-like protein SPARC syndecan-4 |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2021.752892/full |
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