Comparative metabolism and tolerability of racemic primaquine and its enantiomers in human volunteers during 7-day administration

Comparative metabolism and tolerability of racemic primaquine and its enantiomers in human volunteers during 7-day administration

Primaquine (PQ) is an 8-aminoquinoline antimalarial, active against dormant Plasmodium vivax hypnozoites and P. falciparum mature gametocytes. PQ is currently used for P. vivax radical cure and prevention of malaria transmission. PQ is a racemic drug and since the metabolism and pharmacology of PQ’s...

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Bibliographic Details
Main Authors: Washim Khan, Yan-Hong Wang, Narayan D. Chaurasiya, N. P. Dhammika Nanayakkara, H. M. Bandara Herath, Kerri A. Harrison, Gray Dale, Donald A. Stanford, Eric P. Dahl, James D. McChesney, Waseem Gul, Mahmoud A. ElSohly, David Jollow, Babu L. Tekwani, Larry A. Walker
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Pharmacology
Subjects:
primaquine
enantiomers
racemate
metabolism
clinical pharmacokinetics
safety
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.1104735/full

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