The relationship between the monocyte-to-lymphocyte ratio and osteoporosis in postmenopausal females with T2DM: A retrospective study in Chinese population
IntroductionThe risk of fragility fractures is increased in patients with type 2 diabetes mellitus (T2DM). Many reports indicate that inflammatory and immune responses are associated with osteoporosis and osteopenia. The monocyte-to-lymphocyte ratio (MLR) is a novel potential marker of inflammatory...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-02-01
|
| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1112534/full |
| _version_ | 1797902584444354560 |
|---|---|
| author | Hailin Li Xinqi Zhang Qi Zhang Qiong Zhang Xueying Zhu Tuxiu Xie Shuo Wang |
| author_facet | Hailin Li Xinqi Zhang Qi Zhang Qiong Zhang Xueying Zhu Tuxiu Xie Shuo Wang |
| author_sort | Hailin Li |
| collection | DOAJ |
| description | IntroductionThe risk of fragility fractures is increased in patients with type 2 diabetes mellitus (T2DM). Many reports indicate that inflammatory and immune responses are associated with osteoporosis and osteopenia. The monocyte-to-lymphocyte ratio (MLR) is a novel potential marker of inflammatory and immune responses. The present study evaluated the associations between the MLR and osteoporosis in postmenopausal females with T2DM.MethodsData were obtained from 281 T2MD postmenopausal females, and divided into three groups: Osteoporosis group, osteopenia group and normal BMD group. ResultData analyses revealed that the MLR was significantly lower in T2MD postmenopausal females with osteoporosis than in those with osteopenia and normal BMD. Logistic regression showed that the MLR was an independent protective factor for osteoporosis in postmenopausal females with T2DM (odds ratio [OR]: 0.015, 95% confidence interval [CI]: 0.000–0.772). Based on the receiver operating characteristic (ROC) curve, the MLR for diagnosing osteoporosis in postmenopausal females with T2DM was projected to be 0.1019, an area under the curve of 0.761 (95% CI: 0.685–0.838), a sensitivity of 74.8% and a specificity of 25.9%. ConclusionsThe MLR have a high efficacy in diagnosis for osteoporosis in postmenopausal females with T2DM. MLR have the potential to be used as diagnosis marker for osteoporosis in postmenopausal females with T2DM. |
| first_indexed | 2024-04-10T09:19:53Z |
| format | Article |
| id | doaj.art-80215aac2bf646ae80ac8cd34826274a |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-10T09:19:53Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-80215aac2bf646ae80ac8cd34826274a2023-02-20T14:59:33ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-02-011410.3389/fendo.2023.11125341112534The relationship between the monocyte-to-lymphocyte ratio and osteoporosis in postmenopausal females with T2DM: A retrospective study in Chinese populationHailin Li0Xinqi Zhang1Qi Zhang2Qiong Zhang3Xueying Zhu4Tuxiu Xie5Shuo Wang6Department of General Family Medicine, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of General Family Medicine, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of General Family Medicine, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of General Family Medicine, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of General Family Medicine, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of General Family Medicine, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Endocrinology & Metabolism, Renmin Hospital of Wuhan University, Wuhan, ChinaIntroductionThe risk of fragility fractures is increased in patients with type 2 diabetes mellitus (T2DM). Many reports indicate that inflammatory and immune responses are associated with osteoporosis and osteopenia. The monocyte-to-lymphocyte ratio (MLR) is a novel potential marker of inflammatory and immune responses. The present study evaluated the associations between the MLR and osteoporosis in postmenopausal females with T2DM.MethodsData were obtained from 281 T2MD postmenopausal females, and divided into three groups: Osteoporosis group, osteopenia group and normal BMD group. ResultData analyses revealed that the MLR was significantly lower in T2MD postmenopausal females with osteoporosis than in those with osteopenia and normal BMD. Logistic regression showed that the MLR was an independent protective factor for osteoporosis in postmenopausal females with T2DM (odds ratio [OR]: 0.015, 95% confidence interval [CI]: 0.000–0.772). Based on the receiver operating characteristic (ROC) curve, the MLR for diagnosing osteoporosis in postmenopausal females with T2DM was projected to be 0.1019, an area under the curve of 0.761 (95% CI: 0.685–0.838), a sensitivity of 74.8% and a specificity of 25.9%. ConclusionsThe MLR have a high efficacy in diagnosis for osteoporosis in postmenopausal females with T2DM. MLR have the potential to be used as diagnosis marker for osteoporosis in postmenopausal females with T2DM.https://www.frontiersin.org/articles/10.3389/fendo.2023.1112534/fullosteoporosisT2DMpostmenopausal femalesmonocyte-to-lymphocyteretrospective study |
| spellingShingle | Hailin Li Xinqi Zhang Qi Zhang Qiong Zhang Xueying Zhu Tuxiu Xie Shuo Wang The relationship between the monocyte-to-lymphocyte ratio and osteoporosis in postmenopausal females with T2DM: A retrospective study in Chinese population Frontiers in Endocrinology osteoporosis T2DM postmenopausal females monocyte-to-lymphocyte retrospective study |
| title | The relationship between the monocyte-to-lymphocyte ratio and osteoporosis in postmenopausal females with T2DM: A retrospective study in Chinese population |
| title_full | The relationship between the monocyte-to-lymphocyte ratio and osteoporosis in postmenopausal females with T2DM: A retrospective study in Chinese population |
| title_fullStr | The relationship between the monocyte-to-lymphocyte ratio and osteoporosis in postmenopausal females with T2DM: A retrospective study in Chinese population |
| title_full_unstemmed | The relationship between the monocyte-to-lymphocyte ratio and osteoporosis in postmenopausal females with T2DM: A retrospective study in Chinese population |
| title_short | The relationship between the monocyte-to-lymphocyte ratio and osteoporosis in postmenopausal females with T2DM: A retrospective study in Chinese population |
| title_sort | relationship between the monocyte to lymphocyte ratio and osteoporosis in postmenopausal females with t2dm a retrospective study in chinese population |
| topic | osteoporosis T2DM postmenopausal females monocyte-to-lymphocyte retrospective study |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1112534/full |
| work_keys_str_mv | AT hailinli therelationshipbetweenthemonocytetolymphocyteratioandosteoporosisinpostmenopausalfemaleswitht2dmaretrospectivestudyinchinesepopulation AT xinqizhang therelationshipbetweenthemonocytetolymphocyteratioandosteoporosisinpostmenopausalfemaleswitht2dmaretrospectivestudyinchinesepopulation AT qizhang therelationshipbetweenthemonocytetolymphocyteratioandosteoporosisinpostmenopausalfemaleswitht2dmaretrospectivestudyinchinesepopulation AT qiongzhang therelationshipbetweenthemonocytetolymphocyteratioandosteoporosisinpostmenopausalfemaleswitht2dmaretrospectivestudyinchinesepopulation AT xueyingzhu therelationshipbetweenthemonocytetolymphocyteratioandosteoporosisinpostmenopausalfemaleswitht2dmaretrospectivestudyinchinesepopulation AT tuxiuxie therelationshipbetweenthemonocytetolymphocyteratioandosteoporosisinpostmenopausalfemaleswitht2dmaretrospectivestudyinchinesepopulation AT shuowang therelationshipbetweenthemonocytetolymphocyteratioandosteoporosisinpostmenopausalfemaleswitht2dmaretrospectivestudyinchinesepopulation AT hailinli relationshipbetweenthemonocytetolymphocyteratioandosteoporosisinpostmenopausalfemaleswitht2dmaretrospectivestudyinchinesepopulation AT xinqizhang relationshipbetweenthemonocytetolymphocyteratioandosteoporosisinpostmenopausalfemaleswitht2dmaretrospectivestudyinchinesepopulation AT qizhang relationshipbetweenthemonocytetolymphocyteratioandosteoporosisinpostmenopausalfemaleswitht2dmaretrospectivestudyinchinesepopulation AT qiongzhang relationshipbetweenthemonocytetolymphocyteratioandosteoporosisinpostmenopausalfemaleswitht2dmaretrospectivestudyinchinesepopulation AT xueyingzhu relationshipbetweenthemonocytetolymphocyteratioandosteoporosisinpostmenopausalfemaleswitht2dmaretrospectivestudyinchinesepopulation AT tuxiuxie relationshipbetweenthemonocytetolymphocyteratioandosteoporosisinpostmenopausalfemaleswitht2dmaretrospectivestudyinchinesepopulation AT shuowang relationshipbetweenthemonocytetolymphocyteratioandosteoporosisinpostmenopausalfemaleswitht2dmaretrospectivestudyinchinesepopulation |