Role of carboxylic organic molecules in interfibrillar collagen mineralization
Bone is a composite material made up of inorganic and organic counterparts. Most of the inorganic counterpart accounts for calcium phosphate (CaP) whereas the major organic part is composed of collagen. The interfibrillar mineralization of collagen is an important step in the biomineralization of bo...
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| Format: | Article |
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2023.1150037/full |
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| author | Abhishek Indurkar Abhishek Indurkar Rajan Choudhary Rajan Choudhary Kristaps Rubenis Kristaps Rubenis Janis Locs Janis Locs |
| author_facet | Abhishek Indurkar Abhishek Indurkar Rajan Choudhary Rajan Choudhary Kristaps Rubenis Kristaps Rubenis Janis Locs Janis Locs |
| author_sort | Abhishek Indurkar |
| collection | DOAJ |
| description | Bone is a composite material made up of inorganic and organic counterparts. Most of the inorganic counterpart accounts for calcium phosphate (CaP) whereas the major organic part is composed of collagen. The interfibrillar mineralization of collagen is an important step in the biomineralization of bone and tooth. Studies have shown that synthetic CaP undergoes auto-transformation to apatite nanocrystals before entering the gap zone of collagen. Also, the synthetic amorphous calcium phosphate/collagen combination alone is not capable of initiating apatite nucleation rapidly. Therefore, it was understood that there is the presence of a nucleation catalyst obstructing the auto-transformation of CaP before entering the collagen gap zone and initiating rapid nucleation after entering the collagen gap zone. Therefore, studies were focused on finding the nucleation catalyst responsible for the regulation of interfibrillar collagen mineralization. Organic macromolecules and low-molecular-weight carboxylic compounds are predominantly present in the bone and tooth. These organic compounds can interact with both apatite and collagen. Adsorption of the organic compounds on the apatite nanocrystal governs the nucleation, crystal growth, lattice orientation, particle size, and distribution. Additionally, they prevent the auto-transformation of CaP into apatite before entering the interfibrillar compartment of the collagen fibril. Therefore, many carboxylic organic compounds have been utilized in developing CaP. In this review, we have covered different carboxylate organic compounds governing collagen interfibrillar mineralization. |
| first_indexed | 2024-04-09T19:29:00Z |
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| id | doaj.art-80268daf7f82475f8dd6d2176c9413c3 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-04-09T19:29:00Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-80268daf7f82475f8dd6d2176c9413c32023-04-05T04:49:52ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852023-04-011110.3389/fbioe.2023.11500371150037Role of carboxylic organic molecules in interfibrillar collagen mineralizationAbhishek Indurkar0Abhishek Indurkar1Rajan Choudhary2Rajan Choudhary3Kristaps Rubenis4Kristaps Rubenis5Janis Locs6Janis Locs7Rudolfs Cimdins Riga Biomaterials Innovations and Development Centre of RTU, Institute of General Chemical Engineering, Faculty of Materials Science and Applied Chemistry, Riga Technical University, Riga, LatviaBaltic Biomaterials Centre of Excellence, Headquarters at Riga Technical University, Riga, LatviaRudolfs Cimdins Riga Biomaterials Innovations and Development Centre of RTU, Institute of General Chemical Engineering, Faculty of Materials Science and Applied Chemistry, Riga Technical University, Riga, LatviaBaltic Biomaterials Centre of Excellence, Headquarters at Riga Technical University, Riga, LatviaRudolfs Cimdins Riga Biomaterials Innovations and Development Centre of RTU, Institute of General Chemical Engineering, Faculty of Materials Science and Applied Chemistry, Riga Technical University, Riga, LatviaBaltic Biomaterials Centre of Excellence, Headquarters at Riga Technical University, Riga, LatviaRudolfs Cimdins Riga Biomaterials Innovations and Development Centre of RTU, Institute of General Chemical Engineering, Faculty of Materials Science and Applied Chemistry, Riga Technical University, Riga, LatviaBaltic Biomaterials Centre of Excellence, Headquarters at Riga Technical University, Riga, LatviaBone is a composite material made up of inorganic and organic counterparts. Most of the inorganic counterpart accounts for calcium phosphate (CaP) whereas the major organic part is composed of collagen. The interfibrillar mineralization of collagen is an important step in the biomineralization of bone and tooth. Studies have shown that synthetic CaP undergoes auto-transformation to apatite nanocrystals before entering the gap zone of collagen. Also, the synthetic amorphous calcium phosphate/collagen combination alone is not capable of initiating apatite nucleation rapidly. Therefore, it was understood that there is the presence of a nucleation catalyst obstructing the auto-transformation of CaP before entering the collagen gap zone and initiating rapid nucleation after entering the collagen gap zone. Therefore, studies were focused on finding the nucleation catalyst responsible for the regulation of interfibrillar collagen mineralization. Organic macromolecules and low-molecular-weight carboxylic compounds are predominantly present in the bone and tooth. These organic compounds can interact with both apatite and collagen. Adsorption of the organic compounds on the apatite nanocrystal governs the nucleation, crystal growth, lattice orientation, particle size, and distribution. Additionally, they prevent the auto-transformation of CaP into apatite before entering the interfibrillar compartment of the collagen fibril. Therefore, many carboxylic organic compounds have been utilized in developing CaP. In this review, we have covered different carboxylate organic compounds governing collagen interfibrillar mineralization.https://www.frontiersin.org/articles/10.3389/fbioe.2023.1150037/fullcarboxylate organic compoundcalcium phosphateboneinterfibrillar collagenmineralization |
| spellingShingle | Abhishek Indurkar Abhishek Indurkar Rajan Choudhary Rajan Choudhary Kristaps Rubenis Kristaps Rubenis Janis Locs Janis Locs Role of carboxylic organic molecules in interfibrillar collagen mineralization Frontiers in Bioengineering and Biotechnology carboxylate organic compound calcium phosphate bone interfibrillar collagen mineralization |
| title | Role of carboxylic organic molecules in interfibrillar collagen mineralization |
| title_full | Role of carboxylic organic molecules in interfibrillar collagen mineralization |
| title_fullStr | Role of carboxylic organic molecules in interfibrillar collagen mineralization |
| title_full_unstemmed | Role of carboxylic organic molecules in interfibrillar collagen mineralization |
| title_short | Role of carboxylic organic molecules in interfibrillar collagen mineralization |
| title_sort | role of carboxylic organic molecules in interfibrillar collagen mineralization |
| topic | carboxylate organic compound calcium phosphate bone interfibrillar collagen mineralization |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2023.1150037/full |
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