The Price of Success—The Long-Term Outcomes of Children with Craniopharyngioma—Two Institutions’ Experience
An analysis of patients below 21 years old treated due to craniopharyngioma in the years 1979–2022 was performed with the aim of evaluating the long-term outcome and treatment side-effects. The standard statistical tests were used, and 56 patients with a median age of 11 years were evaluated. Surger...
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| Format: | Article |
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MDPI AG
2023-07-01
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| Series: | Children |
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| Online Access: | https://www.mdpi.com/2227-9067/10/7/1272 |
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| author | Aleksandra Napieralska Marek Mandera Ryszard Sordyl Aleksandra Antosz Barbara Bekman Sławomir Blamek |
| author_facet | Aleksandra Napieralska Marek Mandera Ryszard Sordyl Aleksandra Antosz Barbara Bekman Sławomir Blamek |
| author_sort | Aleksandra Napieralska |
| collection | DOAJ |
| description | An analysis of patients below 21 years old treated due to craniopharyngioma in the years 1979–2022 was performed with the aim of evaluating the long-term outcome and treatment side-effects. The standard statistical tests were used, and 56 patients with a median age of 11 years were evaluated. Surgery was the primary treatment in 55 patients; however, in only 29 it was the only neurosurgical intervention. Eighteen children were treated with radiotherapy (RTH) in primary treatment. The most common neurosurgical side effects observed were visual and endocrine deficits and obesity, which were diagnosed in 27 (49%), 50 (91%), and 25 (52%) patients, respectively. Complications after RTH were diagnosed in 14 cases (32%). During the median follow-up of 8.4 years (range: 0.4–39.8 years), six patients died and the 5- and 10-year overall survival was 97% and 93%, respectively. Five-year progression-free survival for gross total resection, resection with adjuvant RTH, and non-radical resection alone was 83%, 68%, and 23%, respectively (<i>p</i> = 0.0006). Surgery combined with RTH provides comparable results to gross tumor resection in terms of oncologic outcome in craniopharyngioma patients. Adjuvant irradiation applied in primary or salvage treatment improves disease control. The rate of complications is high irrespective of improved surgical and radiotherapeutic management. |
| first_indexed | 2024-03-11T01:11:44Z |
| format | Article |
| id | doaj.art-80269f04355b4b648da55f6fcd34d773 |
| institution | Directory Open Access Journal |
| issn | 2227-9067 |
| language | English |
| last_indexed | 2024-03-11T01:11:44Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj.art-80269f04355b4b648da55f6fcd34d7732023-11-18T18:50:42ZengMDPI AGChildren2227-90672023-07-01107127210.3390/children10071272The Price of Success—The Long-Term Outcomes of Children with Craniopharyngioma—Two Institutions’ ExperienceAleksandra Napieralska0Marek Mandera1Ryszard Sordyl2Aleksandra Antosz3Barbara Bekman4Sławomir Blamek5Radiotherapy Department, MSC National Research Institute of Oncology Gliwice Branch, 44-101 Gliwice, PolandDepartment of Pediatric Neurosurgery, Medical University of Silesia, 40-752 Katowice, PolandDepartment of Pediatric Neurosurgery, Medical University of Silesia, 40-752 Katowice, PolandDepartment of Pediatrics and Pediatric Endocrinology, Faculty of Medical Science, Medical University of Silesia, 40-752 Katowice, PolandRadiotherapy and Brachytherapy Planning Department, MSC National Research Institute of Oncology Gliwice Branch, 44-101 Gliwice, PolandRadiotherapy Department, MSC National Research Institute of Oncology Gliwice Branch, 44-101 Gliwice, PolandAn analysis of patients below 21 years old treated due to craniopharyngioma in the years 1979–2022 was performed with the aim of evaluating the long-term outcome and treatment side-effects. The standard statistical tests were used, and 56 patients with a median age of 11 years were evaluated. Surgery was the primary treatment in 55 patients; however, in only 29 it was the only neurosurgical intervention. Eighteen children were treated with radiotherapy (RTH) in primary treatment. The most common neurosurgical side effects observed were visual and endocrine deficits and obesity, which were diagnosed in 27 (49%), 50 (91%), and 25 (52%) patients, respectively. Complications after RTH were diagnosed in 14 cases (32%). During the median follow-up of 8.4 years (range: 0.4–39.8 years), six patients died and the 5- and 10-year overall survival was 97% and 93%, respectively. Five-year progression-free survival for gross total resection, resection with adjuvant RTH, and non-radical resection alone was 83%, 68%, and 23%, respectively (<i>p</i> = 0.0006). Surgery combined with RTH provides comparable results to gross tumor resection in terms of oncologic outcome in craniopharyngioma patients. Adjuvant irradiation applied in primary or salvage treatment improves disease control. The rate of complications is high irrespective of improved surgical and radiotherapeutic management.https://www.mdpi.com/2227-9067/10/7/1272craniopharyngiomapediatric oncologyendocrinopathieslong-term complications |
| spellingShingle | Aleksandra Napieralska Marek Mandera Ryszard Sordyl Aleksandra Antosz Barbara Bekman Sławomir Blamek The Price of Success—The Long-Term Outcomes of Children with Craniopharyngioma—Two Institutions’ Experience Children craniopharyngioma pediatric oncology endocrinopathies long-term complications |
| title | The Price of Success—The Long-Term Outcomes of Children with Craniopharyngioma—Two Institutions’ Experience |
| title_full | The Price of Success—The Long-Term Outcomes of Children with Craniopharyngioma—Two Institutions’ Experience |
| title_fullStr | The Price of Success—The Long-Term Outcomes of Children with Craniopharyngioma—Two Institutions’ Experience |
| title_full_unstemmed | The Price of Success—The Long-Term Outcomes of Children with Craniopharyngioma—Two Institutions’ Experience |
| title_short | The Price of Success—The Long-Term Outcomes of Children with Craniopharyngioma—Two Institutions’ Experience |
| title_sort | price of success the long term outcomes of children with craniopharyngioma two institutions experience |
| topic | craniopharyngioma pediatric oncology endocrinopathies long-term complications |
| url | https://www.mdpi.com/2227-9067/10/7/1272 |
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