Lactylation, a Novel Metabolic Reprogramming Code: Current Status and Prospects
Lactate is an end product of glycolysis. As a critical energy source for mitochondrial respiration, lactate also acts as a precursor of gluconeogenesis and a signaling molecule. We briefly summarize emerging concepts regarding lactate metabolism, such as the lactate shuttle, lactate homeostasis, and...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2021-06-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.688910/full |
| _version_ | 1831559340089147392 |
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| author | An-Na Chen Yan Luo Yu-Han Yang Jian-Tao Fu Xiu-Mei Geng Jun-Ping Shi Jin Yang |
| author_facet | An-Na Chen Yan Luo Yu-Han Yang Jian-Tao Fu Xiu-Mei Geng Jun-Ping Shi Jin Yang |
| author_sort | An-Na Chen |
| collection | DOAJ |
| description | Lactate is an end product of glycolysis. As a critical energy source for mitochondrial respiration, lactate also acts as a precursor of gluconeogenesis and a signaling molecule. We briefly summarize emerging concepts regarding lactate metabolism, such as the lactate shuttle, lactate homeostasis, and lactate-microenvironment interaction. Accumulating evidence indicates that lactate-mediated reprogramming of immune cells and enhancement of cellular plasticity contribute to establishing disease-specific immunity status. However, the mechanisms by which changes in lactate states influence the establishment of diverse functional adaptive states are largely uncharacterized. Posttranslational histone modifications create a code that functions as a key sensor of metabolism and are responsible for transducing metabolic changes into stable gene expression patterns. In this review, we describe the recent advances in a novel lactate-induced histone modification, histone lysine lactylation. These observations support the idea that epigenetic reprogramming-linked lactate input is related to disease state outputs, such as cancer progression and drug resistance. |
| first_indexed | 2024-12-17T05:27:32Z |
| format | Article |
| id | doaj.art-8028ed34a56f46aa96055617383f4683 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-17T05:27:32Z |
| publishDate | 2021-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-8028ed34a56f46aa96055617383f46832022-12-21T22:01:50ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-06-011210.3389/fimmu.2021.688910688910Lactylation, a Novel Metabolic Reprogramming Code: Current Status and ProspectsAn-Na ChenYan LuoYu-Han YangJian-Tao FuXiu-Mei GengJun-Ping ShiJin YangLactate is an end product of glycolysis. As a critical energy source for mitochondrial respiration, lactate also acts as a precursor of gluconeogenesis and a signaling molecule. We briefly summarize emerging concepts regarding lactate metabolism, such as the lactate shuttle, lactate homeostasis, and lactate-microenvironment interaction. Accumulating evidence indicates that lactate-mediated reprogramming of immune cells and enhancement of cellular plasticity contribute to establishing disease-specific immunity status. However, the mechanisms by which changes in lactate states influence the establishment of diverse functional adaptive states are largely uncharacterized. Posttranslational histone modifications create a code that functions as a key sensor of metabolism and are responsible for transducing metabolic changes into stable gene expression patterns. In this review, we describe the recent advances in a novel lactate-induced histone modification, histone lysine lactylation. These observations support the idea that epigenetic reprogramming-linked lactate input is related to disease state outputs, such as cancer progression and drug resistance.https://www.frontiersin.org/articles/10.3389/fimmu.2021.688910/fulllactatelactylationmacrophageepigeneticposttranslational modification |
| spellingShingle | An-Na Chen Yan Luo Yu-Han Yang Jian-Tao Fu Xiu-Mei Geng Jun-Ping Shi Jin Yang Lactylation, a Novel Metabolic Reprogramming Code: Current Status and Prospects Frontiers in Immunology lactate lactylation macrophage epigenetic posttranslational modification |
| title | Lactylation, a Novel Metabolic Reprogramming Code: Current Status and Prospects |
| title_full | Lactylation, a Novel Metabolic Reprogramming Code: Current Status and Prospects |
| title_fullStr | Lactylation, a Novel Metabolic Reprogramming Code: Current Status and Prospects |
| title_full_unstemmed | Lactylation, a Novel Metabolic Reprogramming Code: Current Status and Prospects |
| title_short | Lactylation, a Novel Metabolic Reprogramming Code: Current Status and Prospects |
| title_sort | lactylation a novel metabolic reprogramming code current status and prospects |
| topic | lactate lactylation macrophage epigenetic posttranslational modification |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2021.688910/full |
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