Multiple myeloma concealed by adrenal Cushing syndrome: a case report and review of the literature
Abstract Background Cushing syndrome coexisting with multiple myeloma has been previously described in a few reports. Overlapping clinical manifestations can lead to misdiagnoses. Case presentation We presented an extremely rare case of a 33-year-old Thai woman with concomitant kappa light chain mye...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-08-01
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| Series: | Journal of Medical Case Reports |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13256-018-1731-y |
| _version_ | 1818616050401411072 |
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| author | Taweesak Wannachalee Nuttagarn Jantanapornchai Kittima Suphadirekkul Sirinart Sirinvaravong Weerapat Owattanapanich |
| author_facet | Taweesak Wannachalee Nuttagarn Jantanapornchai Kittima Suphadirekkul Sirinart Sirinvaravong Weerapat Owattanapanich |
| author_sort | Taweesak Wannachalee |
| collection | DOAJ |
| description | Abstract Background Cushing syndrome coexisting with multiple myeloma has been previously described in a few reports. Overlapping clinical manifestations can lead to misdiagnoses. Case presentation We presented an extremely rare case of a 33-year-old Thai woman with concomitant kappa light chain myeloma with adrenal Cushing syndrome, both of which were related to skeletal manifestations. A precedence report indicated that treatment of the Cushing syndrome could exacerbate the myeloma symptoms. Therefore, we were faced with the dilemma of which disease should be addressed first. We decided to treat our patient with a combination chemotherapy followed by an autologous stem cell transplant. Subsequently, a left laparoscopic adrenalectomy was successfully undertaken. Conclusion We have reported the first association between adrenocorticotropic hormone-independent Cushing syndrome resulting from a left autonomous cortisol-secreting adrenal adenoma, and multiple myeloma. |
| first_indexed | 2024-12-16T16:43:38Z |
| format | Article |
| id | doaj.art-802f01e766c24741886f18f084647724 |
| institution | Directory Open Access Journal |
| issn | 1752-1947 |
| language | English |
| last_indexed | 2024-12-16T16:43:38Z |
| publishDate | 2018-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Medical Case Reports |
| spelling | doaj.art-802f01e766c24741886f18f0846477242022-12-21T22:24:14ZengBMCJournal of Medical Case Reports1752-19472018-08-011211510.1186/s13256-018-1731-yMultiple myeloma concealed by adrenal Cushing syndrome: a case report and review of the literatureTaweesak Wannachalee0Nuttagarn Jantanapornchai1Kittima Suphadirekkul2Sirinart Sirinvaravong3Weerapat Owattanapanich4Division of Endocrine and Metabolism, Department of Medicine, Faculty of Medicine, Siriraj Hospital Mahidol UniversitySena HospitalDivision of Hematology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol UniversityDivision of Endocrine and Metabolism, Department of Medicine, Faculty of Medicine, Siriraj Hospital Mahidol UniversityDivision of Hematology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol UniversityAbstract Background Cushing syndrome coexisting with multiple myeloma has been previously described in a few reports. Overlapping clinical manifestations can lead to misdiagnoses. Case presentation We presented an extremely rare case of a 33-year-old Thai woman with concomitant kappa light chain myeloma with adrenal Cushing syndrome, both of which were related to skeletal manifestations. A precedence report indicated that treatment of the Cushing syndrome could exacerbate the myeloma symptoms. Therefore, we were faced with the dilemma of which disease should be addressed first. We decided to treat our patient with a combination chemotherapy followed by an autologous stem cell transplant. Subsequently, a left laparoscopic adrenalectomy was successfully undertaken. Conclusion We have reported the first association between adrenocorticotropic hormone-independent Cushing syndrome resulting from a left autonomous cortisol-secreting adrenal adenoma, and multiple myeloma.http://link.springer.com/article/10.1186/s13256-018-1731-yMultiple myelomaCushing syndromeAdrenocortical adenomaAdrenalectomy |
| spellingShingle | Taweesak Wannachalee Nuttagarn Jantanapornchai Kittima Suphadirekkul Sirinart Sirinvaravong Weerapat Owattanapanich Multiple myeloma concealed by adrenal Cushing syndrome: a case report and review of the literature Journal of Medical Case Reports Multiple myeloma Cushing syndrome Adrenocortical adenoma Adrenalectomy |
| title | Multiple myeloma concealed by adrenal Cushing syndrome: a case report and review of the literature |
| title_full | Multiple myeloma concealed by adrenal Cushing syndrome: a case report and review of the literature |
| title_fullStr | Multiple myeloma concealed by adrenal Cushing syndrome: a case report and review of the literature |
| title_full_unstemmed | Multiple myeloma concealed by adrenal Cushing syndrome: a case report and review of the literature |
| title_short | Multiple myeloma concealed by adrenal Cushing syndrome: a case report and review of the literature |
| title_sort | multiple myeloma concealed by adrenal cushing syndrome a case report and review of the literature |
| topic | Multiple myeloma Cushing syndrome Adrenocortical adenoma Adrenalectomy |
| url | http://link.springer.com/article/10.1186/s13256-018-1731-y |
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