Simpler and Faster Spectrophotometric Determination of Diclofenac Sodium in Tablets, Serum and Urine Samples
This work describes a simple, sensitive, rapid and economical analytical procedure for direct spectrophotometric evaluation of diclofenac sodium (DS) using aqueous medium without using a chemical reagent. Parameters like time, temperature, acidic and basic conditions and interference by analgesic dr...
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| Format: | Article |
| Language: | English |
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National Centre of Excellence in Analytical Chemsitry
2009-12-01
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| Series: | Pakistan Journal of Analytical & Environmental Chemistry |
| Subjects: | |
| Online Access: | http://www.ceacsu.edu.pk/PDF%20file/Volume%2010%20Issue%201%20&%202/53-58-PJAEC-061009-10-OK.pdf |
| _version_ | 1818808133455183872 |
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| author | Abdul Rauf Khaskheli Sirajuddin Kamran Abro S. T. H. Sherazi H. I. Afridi S. A. Mahesar Munawar Saeed |
| author_facet | Abdul Rauf Khaskheli Sirajuddin Kamran Abro S. T. H. Sherazi H. I. Afridi S. A. Mahesar Munawar Saeed |
| author_sort | Abdul Rauf Khaskheli |
| collection | DOAJ |
| description | This work describes a simple, sensitive, rapid and economical analytical procedure for direct spectrophotometric evaluation of diclofenac sodium (DS) using aqueous medium without using a chemical reagent. Parameters like time, temperature, acidic and basic conditions and interference by analgesic drugs were studied for a 5µg ml-1 solution of DS at 276 nm. Under optimized parameters, a linear working range of 0.1–30 g ml-1 with regression coefficient of 0.9998 and lower detection limit of 0.01 g ml-1 was obtained. The method was applied for DS contents in tablets, serum and urine samples. |
| first_indexed | 2024-12-18T19:36:43Z |
| format | Article |
| id | doaj.art-802f3f998b8f4d2dac9b53f57c5e3c6e |
| institution | Directory Open Access Journal |
| issn | 1996-918X 2221-5255 |
| language | English |
| last_indexed | 2024-12-18T19:36:43Z |
| publishDate | 2009-12-01 |
| publisher | National Centre of Excellence in Analytical Chemsitry |
| record_format | Article |
| series | Pakistan Journal of Analytical & Environmental Chemistry |
| spelling | doaj.art-802f3f998b8f4d2dac9b53f57c5e3c6e2022-12-21T20:55:34ZengNational Centre of Excellence in Analytical ChemsitryPakistan Journal of Analytical & Environmental Chemistry1996-918X2221-52552009-12-01101-25358Simpler and Faster Spectrophotometric Determination of Diclofenac Sodium in Tablets, Serum and Urine SamplesAbdul Rauf KhaskheliSirajuddinKamran AbroS. T. H. SheraziH. I. AfridiS. A. MahesarMunawar SaeedThis work describes a simple, sensitive, rapid and economical analytical procedure for direct spectrophotometric evaluation of diclofenac sodium (DS) using aqueous medium without using a chemical reagent. Parameters like time, temperature, acidic and basic conditions and interference by analgesic drugs were studied for a 5µg ml-1 solution of DS at 276 nm. Under optimized parameters, a linear working range of 0.1–30 g ml-1 with regression coefficient of 0.9998 and lower detection limit of 0.01 g ml-1 was obtained. The method was applied for DS contents in tablets, serum and urine samples.http://www.ceacsu.edu.pk/PDF%20file/Volume%2010%20Issue%201%20&%202/53-58-PJAEC-061009-10-OK.pdfDiclofenac sodiumUV-Visible spectrophotometertabletsserumurine |
| spellingShingle | Abdul Rauf Khaskheli Sirajuddin Kamran Abro S. T. H. Sherazi H. I. Afridi S. A. Mahesar Munawar Saeed Simpler and Faster Spectrophotometric Determination of Diclofenac Sodium in Tablets, Serum and Urine Samples Pakistan Journal of Analytical & Environmental Chemistry Diclofenac sodium UV-Visible spectrophotometer tablets serum urine |
| title | Simpler and Faster Spectrophotometric Determination of Diclofenac Sodium in Tablets, Serum and Urine Samples |
| title_full | Simpler and Faster Spectrophotometric Determination of Diclofenac Sodium in Tablets, Serum and Urine Samples |
| title_fullStr | Simpler and Faster Spectrophotometric Determination of Diclofenac Sodium in Tablets, Serum and Urine Samples |
| title_full_unstemmed | Simpler and Faster Spectrophotometric Determination of Diclofenac Sodium in Tablets, Serum and Urine Samples |
| title_short | Simpler and Faster Spectrophotometric Determination of Diclofenac Sodium in Tablets, Serum and Urine Samples |
| title_sort | simpler and faster spectrophotometric determination of diclofenac sodium in tablets serum and urine samples |
| topic | Diclofenac sodium UV-Visible spectrophotometer tablets serum urine |
| url | http://www.ceacsu.edu.pk/PDF%20file/Volume%2010%20Issue%201%20&%202/53-58-PJAEC-061009-10-OK.pdf |
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