Marine Heterocyclic Compounds That Modulate Intracellular Calcium Signals: Chemistry and Synthesis Approaches
Intracellular Ca<sup>2+</sup> plays a pivotal role in the control of a large series of cell functions in all types of cells, from neurotransmitter release and muscle contraction to gene expression, cell proliferation and cell death. Ca<sup>2+</sup> is transported through spec...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-01-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/19/2/78 |
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| author | Paula González-Andrés Laura Fernández-Peña Carlos Díez-Poza Carlos Villalobos Lucía Nuñez Asunción Barbero |
| author_facet | Paula González-Andrés Laura Fernández-Peña Carlos Díez-Poza Carlos Villalobos Lucía Nuñez Asunción Barbero |
| author_sort | Paula González-Andrés |
| collection | DOAJ |
| description | Intracellular Ca<sup>2+</sup> plays a pivotal role in the control of a large series of cell functions in all types of cells, from neurotransmitter release and muscle contraction to gene expression, cell proliferation and cell death. Ca<sup>2+</sup> is transported through specific channels and transporters in the plasma membrane and subcellular organelles such as the endoplasmic reticulum and mitochondria. Therefore, dysregulation of intracellular Ca<sup>2+</sup> homeostasis may lead to cell dysfunction and disease. Accordingly, chemical compounds from natural origin and/or synthesis targeting directly or indirectly these channels and proteins may be of interest for the treatment of cell dysfunction and disease. In this review, we show an overview of a group of marine drugs that, from the structural point of view, contain one or various heterocyclic units in their core structure, and from the biological side, they have a direct influence on the transport of calcium in the cell. The marine compounds covered in this review are divided into three groups, which correspond with their direct biological activity, such as compounds with a direct influence in the calcium channel, compounds with a direct effect on the cytoskeleton and drugs with an effect on cancer cell proliferation. For each target, we describe its bioactive properties and synthetic approaches. The wide variety of chemical structures compiled in this review and their significant medical properties may attract the attention of many different researchers. |
| first_indexed | 2024-03-09T06:18:53Z |
| format | Article |
| id | doaj.art-803025b55d5140759cfdf1eda73ac0db |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-03-09T06:18:53Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-803025b55d5140759cfdf1eda73ac0db2023-12-03T11:49:54ZengMDPI AGMarine Drugs1660-33972021-01-011927810.3390/md19020078Marine Heterocyclic Compounds That Modulate Intracellular Calcium Signals: Chemistry and Synthesis ApproachesPaula González-Andrés0Laura Fernández-Peña1Carlos Díez-Poza2Carlos Villalobos3Lucía Nuñez4Asunción Barbero5Department of Organic Chemistry, Campus Miguel Delibes, University of Valladolid, 47011 Valladolid, SpainDepartment of Organic Chemistry, Campus Miguel Delibes, University of Valladolid, 47011 Valladolid, SpainDepartment of Organic Chemistry, Campus Miguel Delibes, University of Valladolid, 47011 Valladolid, SpainInstitute of Biology and Molecular Genetics (IBGM), University of Valladolid and Spanish National Research Council (CSIC), 47003 Valladolid, SpainInstitute of Biology and Molecular Genetics (IBGM), University of Valladolid and Spanish National Research Council (CSIC), 47003 Valladolid, SpainDepartment of Organic Chemistry, Campus Miguel Delibes, University of Valladolid, 47011 Valladolid, SpainIntracellular Ca<sup>2+</sup> plays a pivotal role in the control of a large series of cell functions in all types of cells, from neurotransmitter release and muscle contraction to gene expression, cell proliferation and cell death. Ca<sup>2+</sup> is transported through specific channels and transporters in the plasma membrane and subcellular organelles such as the endoplasmic reticulum and mitochondria. Therefore, dysregulation of intracellular Ca<sup>2+</sup> homeostasis may lead to cell dysfunction and disease. Accordingly, chemical compounds from natural origin and/or synthesis targeting directly or indirectly these channels and proteins may be of interest for the treatment of cell dysfunction and disease. In this review, we show an overview of a group of marine drugs that, from the structural point of view, contain one or various heterocyclic units in their core structure, and from the biological side, they have a direct influence on the transport of calcium in the cell. The marine compounds covered in this review are divided into three groups, which correspond with their direct biological activity, such as compounds with a direct influence in the calcium channel, compounds with a direct effect on the cytoskeleton and drugs with an effect on cancer cell proliferation. For each target, we describe its bioactive properties and synthetic approaches. The wide variety of chemical structures compiled in this review and their significant medical properties may attract the attention of many different researchers.https://www.mdpi.com/1660-3397/19/2/78marine drugsheterocyclescalcium channeltotal synthesismedicinal properties |
| spellingShingle | Paula González-Andrés Laura Fernández-Peña Carlos Díez-Poza Carlos Villalobos Lucía Nuñez Asunción Barbero Marine Heterocyclic Compounds That Modulate Intracellular Calcium Signals: Chemistry and Synthesis Approaches Marine Drugs marine drugs heterocycles calcium channel total synthesis medicinal properties |
| title | Marine Heterocyclic Compounds That Modulate Intracellular Calcium Signals: Chemistry and Synthesis Approaches |
| title_full | Marine Heterocyclic Compounds That Modulate Intracellular Calcium Signals: Chemistry and Synthesis Approaches |
| title_fullStr | Marine Heterocyclic Compounds That Modulate Intracellular Calcium Signals: Chemistry and Synthesis Approaches |
| title_full_unstemmed | Marine Heterocyclic Compounds That Modulate Intracellular Calcium Signals: Chemistry and Synthesis Approaches |
| title_short | Marine Heterocyclic Compounds That Modulate Intracellular Calcium Signals: Chemistry and Synthesis Approaches |
| title_sort | marine heterocyclic compounds that modulate intracellular calcium signals chemistry and synthesis approaches |
| topic | marine drugs heterocycles calcium channel total synthesis medicinal properties |
| url | https://www.mdpi.com/1660-3397/19/2/78 |
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