Inactivation of TFEB and NF-κB by marchantin M alleviates the chemotherapy-driven pro-tumorigenic senescent secretion

Inactivation of TFEB and NF-κB by marchantin M alleviates the chemotherapy-driven pro-tumorigenic senescent secretion

It is critical to regulate the senescence-associated secretory phenotype (SASP) due to its effect on promoting malignant phenotypes and limiting the efficiency of cancer therapy. In this study, we demonstrated that marchantin M (Mar-M, a naturally occurring bisbibenzyl) suppressed pro-inflammatory S...

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Bibliographic Details
Main Authors: Huanmin Niu, Lilin Qian, Bin Sun, Wenjian Liu, Fang Wang, Qian Wang, Xiaotian Ji, Yanhai Luo, Effat Un Nesa, Hongxiang Lou, Huiqing Yuan
Format: Article
Language:English
Published: Elsevier 2019-09-01
Series:Acta Pharmaceutica Sinica B
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383519303958

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