New Clues to Understanding HIV Nonprogressors: Low Cholesterol Blocks HIV <italic toggle="yes">Trans</italic> Infection
ABSTRACT A small percentage of HIV-infected subjects (2 to 15%) are able to control disease progression for many years without antiretroviral therapy. Years of intense studies of virologic and immunologic mechanisms of disease control in such individuals yielded a number of possible host genes that...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
American Society for Microbiology
2014-07-01
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| Series: | mBio |
| Online Access: | https://journals.asm.org/doi/10.1128/mBio.01396-14 |
| _version_ | 1818424702367956992 |
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| author | Vinayaka R. Prasad Michael I. Bukrinsky |
| author_facet | Vinayaka R. Prasad Michael I. Bukrinsky |
| author_sort | Vinayaka R. Prasad |
| collection | DOAJ |
| description | ABSTRACT A small percentage of HIV-infected subjects (2 to 15%) are able to control disease progression for many years without antiretroviral therapy. Years of intense studies of virologic and immunologic mechanisms of disease control in such individuals yielded a number of possible host genes that could be responsible for the preservation of immune functions, from immune surveillance genes, chemokines, or their receptors to anti-HIV restriction factors. A recent mBio paper by Rappocciolo et al. (G. Rappocciolo, M. Jais, P. Piazza, T. A. Reinhart, S. J. Berendam, L. Garcia-Exposito, P. Gupta, and C. R. Rinaldo, mBio 5:e01031-13, 2014) describes another potential factor controlling disease progression: cholesterol levels in antigen-presenting cells. In this commentary, we provide a brief background of the role of cholesterol in HIV infection, discuss the results of the study by Rappocciolo et al., and present the implications of their findings. |
| first_indexed | 2024-12-14T14:02:14Z |
| format | Article |
| id | doaj.art-8034bd37e091475db8918b2804eddb9a |
| institution | Directory Open Access Journal |
| issn | 2150-7511 |
| language | English |
| last_indexed | 2024-12-14T14:02:14Z |
| publishDate | 2014-07-01 |
| publisher | American Society for Microbiology |
| record_format | Article |
| series | mBio |
| spelling | doaj.art-8034bd37e091475db8918b2804eddb9a2022-12-21T22:58:42ZengAmerican Society for MicrobiologymBio2150-75112014-07-015310.1128/mBio.01396-14New Clues to Understanding HIV Nonprogressors: Low Cholesterol Blocks HIV <italic toggle="yes">Trans</italic> InfectionVinayaka R. Prasad0Michael I. Bukrinsky1Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USADepartment of Microbiology, Immunology, and Tropical Medicine, The George Washington University School of Medicine and Health Sciences, Washington, DC, USAABSTRACT A small percentage of HIV-infected subjects (2 to 15%) are able to control disease progression for many years without antiretroviral therapy. Years of intense studies of virologic and immunologic mechanisms of disease control in such individuals yielded a number of possible host genes that could be responsible for the preservation of immune functions, from immune surveillance genes, chemokines, or their receptors to anti-HIV restriction factors. A recent mBio paper by Rappocciolo et al. (G. Rappocciolo, M. Jais, P. Piazza, T. A. Reinhart, S. J. Berendam, L. Garcia-Exposito, P. Gupta, and C. R. Rinaldo, mBio 5:e01031-13, 2014) describes another potential factor controlling disease progression: cholesterol levels in antigen-presenting cells. In this commentary, we provide a brief background of the role of cholesterol in HIV infection, discuss the results of the study by Rappocciolo et al., and present the implications of their findings.https://journals.asm.org/doi/10.1128/mBio.01396-14 |
| spellingShingle | Vinayaka R. Prasad Michael I. Bukrinsky New Clues to Understanding HIV Nonprogressors: Low Cholesterol Blocks HIV <italic toggle="yes">Trans</italic> Infection mBio |
| title | New Clues to Understanding HIV Nonprogressors: Low Cholesterol Blocks HIV <italic toggle="yes">Trans</italic> Infection |
| title_full | New Clues to Understanding HIV Nonprogressors: Low Cholesterol Blocks HIV <italic toggle="yes">Trans</italic> Infection |
| title_fullStr | New Clues to Understanding HIV Nonprogressors: Low Cholesterol Blocks HIV <italic toggle="yes">Trans</italic> Infection |
| title_full_unstemmed | New Clues to Understanding HIV Nonprogressors: Low Cholesterol Blocks HIV <italic toggle="yes">Trans</italic> Infection |
| title_short | New Clues to Understanding HIV Nonprogressors: Low Cholesterol Blocks HIV <italic toggle="yes">Trans</italic> Infection |
| title_sort | new clues to understanding hiv nonprogressors low cholesterol blocks hiv italic toggle yes trans italic infection |
| url | https://journals.asm.org/doi/10.1128/mBio.01396-14 |
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