ALDH2 Polymorphism rs671 *1/*2 Genotype is a Risk Factor for the Development of Alcoholic Liver Cirrhosis in Hakka Alcoholics
Yijin Chen,1,2,* Hongtao Liu,2,3,* Zhikang Yu,2,4 Yang Yang,1,2 Qingyan Huang,2,4 Changqing Deng,1,2 Hui Rao,2,4 Heming Wu2,4 1Department of Gastroenterology, Meizhou People’s Hospital (Huangtang Hospital), Meizhou Academy of Medical Sciences, Meizhou, People’s Republic of China; 2Gu...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2022-04-01
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| Series: | International Journal of General Medicine |
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| Online Access: | https://www.dovepress.com/aldh2-polymorphism-rs671-12-genotype-is-a-risk-factor-for-the-developm-peer-reviewed-fulltext-article-IJGM |
| _version_ | 1818115881150971904 |
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| author | Chen Y Liu H Yu Z Yang Y Huang Q Deng C Rao H Wu H |
| author_facet | Chen Y Liu H Yu Z Yang Y Huang Q Deng C Rao H Wu H |
| author_sort | Chen Y |
| collection | DOAJ |
| description | Yijin Chen,1,2,* Hongtao Liu,2,3,* Zhikang Yu,2,4 Yang Yang,1,2 Qingyan Huang,2,4 Changqing Deng,1,2 Hui Rao,2,4 Heming Wu2,4 1Department of Gastroenterology, Meizhou People’s Hospital (Huangtang Hospital), Meizhou Academy of Medical Sciences, Meizhou, People’s Republic of China; 2Guangdong Provincial Key Laboratory of Precision Medicine and Clinical Translational Research of Hakka Population, Meizhou People’s Hospital (Huangtang Hospital), Meizhou Academy of Medical Sciences, Meizhou, People’s Republic of China; 3Department of Gastrointestinal Surgery, Meizhou People’s Hospital (Huangtang Hospital), Meizhou Academy of Medical Sciences, Meizhou, People’s Republic of China; 4Center for Precision Medicine, Meizhou People’s Hospital (Huangtang Hospital), Meizhou Academy of Medical Sciences, Meizhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Heming Wu, Center for Precision Medicine, Meizhou People’s Hospital (Huangtang Hospital), Meizhou Academy of Medical Sciences, No. 63 Huangtang Road, Meijiang District, Meizhou, 514031, People’s Republic of China, Tel +86 753-2131-591, Email wuheming1986@126.comBackground: Alcoholics are prone to alcoholic cirrhosis (ALC). Aldehyde dehydrogenase 2 (ALDH2) is involved in alcohol metabolism. Herein, the relationship between ALDH2 genotypes and ALC was analyzed among Hakka alcoholics in southern China.Methods: A total of 213 alcoholics and 214 non-alcoholics were included in the study. The ALDH2 gene rs671 polymorphism was analyzed, life history, disease history, and auxiliary examination results of these participants were collected.Results: The alcoholics had higher level of total serum protein, and serum globulin, lower level of serum albumin, serum albumin/globulin ratio, serum prealbumin, neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), and platelet-to-lymphocyte ratio (PLR) than non-alcoholics. In the 213 alcoholics, 180 developed ALC. There were 206 non-ALC persons in the 214 non-alcoholics. The proportion of the ALDH2 rs671 G/G homozygous (*1/*1) was significantly lower in ALC patients (83.3%) than that of other groups (100.0% in non-ALC in alcoholics, 95.6% in non-ALC in non-alcoholics), while the proportion of the G/A heterozygous (*1/*2) was significantly higher in ALC patients (16.7%) than that of other groups (0% in non-ALC in alcoholics, 4.4% in non-ALC in non-alcoholics). Logistic regression analysis indicated that participants with low level of NLR (adjusted OR 5.543, 95% CI 2.964– 10.368, P< 0.001), LMR (adjusted OR 9.256, 95% CI 4.740– 18.076, P< 0.001), and PLR (adjusted OR 6.047, 95% CI 3.372– 10.845, P< 0.001), and ALDH2 G/A genotype (adjusted OR 6.323, 95% CI 2.477– 16.140, P< 0.001) had a significantly higher risk of ALC.Conclusion: ALDH2 polymorphism rs671 *1/*2 genotype is a potential risk factor for the development of ALC among Hakka alcoholics.Keywords: ALDH2, alcoholics, alcoholic liver cirrhosis, gene polymorphism, Hakka |
| first_indexed | 2024-12-11T04:13:40Z |
| format | Article |
| id | doaj.art-8037e3b03495499f9aef7f70a9d0eec4 |
| institution | Directory Open Access Journal |
| issn | 1178-7074 |
| language | English |
| last_indexed | 2024-12-11T04:13:40Z |
| publishDate | 2022-04-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of General Medicine |
| spelling | doaj.art-8037e3b03495499f9aef7f70a9d0eec42022-12-22T01:21:19ZengDove Medical PressInternational Journal of General Medicine1178-70742022-04-01Volume 154067407774534ALDH2 Polymorphism rs671 *1/*2 Genotype is a Risk Factor for the Development of Alcoholic Liver Cirrhosis in Hakka AlcoholicsChen YLiu HYu ZYang YHuang QDeng CRao HWu HYijin Chen,1,2,* Hongtao Liu,2,3,* Zhikang Yu,2,4 Yang Yang,1,2 Qingyan Huang,2,4 Changqing Deng,1,2 Hui Rao,2,4 Heming Wu2,4 1Department of Gastroenterology, Meizhou People’s Hospital (Huangtang Hospital), Meizhou Academy of Medical Sciences, Meizhou, People’s Republic of China; 2Guangdong Provincial Key Laboratory of Precision Medicine and Clinical Translational Research of Hakka Population, Meizhou People’s Hospital (Huangtang Hospital), Meizhou Academy of Medical Sciences, Meizhou, People’s Republic of China; 3Department of Gastrointestinal Surgery, Meizhou People’s Hospital (Huangtang Hospital), Meizhou Academy of Medical Sciences, Meizhou, People’s Republic of China; 4Center for Precision Medicine, Meizhou People’s Hospital (Huangtang Hospital), Meizhou Academy of Medical Sciences, Meizhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Heming Wu, Center for Precision Medicine, Meizhou People’s Hospital (Huangtang Hospital), Meizhou Academy of Medical Sciences, No. 63 Huangtang Road, Meijiang District, Meizhou, 514031, People’s Republic of China, Tel +86 753-2131-591, Email wuheming1986@126.comBackground: Alcoholics are prone to alcoholic cirrhosis (ALC). Aldehyde dehydrogenase 2 (ALDH2) is involved in alcohol metabolism. Herein, the relationship between ALDH2 genotypes and ALC was analyzed among Hakka alcoholics in southern China.Methods: A total of 213 alcoholics and 214 non-alcoholics were included in the study. The ALDH2 gene rs671 polymorphism was analyzed, life history, disease history, and auxiliary examination results of these participants were collected.Results: The alcoholics had higher level of total serum protein, and serum globulin, lower level of serum albumin, serum albumin/globulin ratio, serum prealbumin, neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), and platelet-to-lymphocyte ratio (PLR) than non-alcoholics. In the 213 alcoholics, 180 developed ALC. There were 206 non-ALC persons in the 214 non-alcoholics. The proportion of the ALDH2 rs671 G/G homozygous (*1/*1) was significantly lower in ALC patients (83.3%) than that of other groups (100.0% in non-ALC in alcoholics, 95.6% in non-ALC in non-alcoholics), while the proportion of the G/A heterozygous (*1/*2) was significantly higher in ALC patients (16.7%) than that of other groups (0% in non-ALC in alcoholics, 4.4% in non-ALC in non-alcoholics). Logistic regression analysis indicated that participants with low level of NLR (adjusted OR 5.543, 95% CI 2.964– 10.368, P< 0.001), LMR (adjusted OR 9.256, 95% CI 4.740– 18.076, P< 0.001), and PLR (adjusted OR 6.047, 95% CI 3.372– 10.845, P< 0.001), and ALDH2 G/A genotype (adjusted OR 6.323, 95% CI 2.477– 16.140, P< 0.001) had a significantly higher risk of ALC.Conclusion: ALDH2 polymorphism rs671 *1/*2 genotype is a potential risk factor for the development of ALC among Hakka alcoholics.Keywords: ALDH2, alcoholics, alcoholic liver cirrhosis, gene polymorphism, Hakkahttps://www.dovepress.com/aldh2-polymorphism-rs671-12-genotype-is-a-risk-factor-for-the-developm-peer-reviewed-fulltext-article-IJGMaldh2alcoholicsalcoholic liver cirrhosisgene polymorphismhakka |
| spellingShingle | Chen Y Liu H Yu Z Yang Y Huang Q Deng C Rao H Wu H ALDH2 Polymorphism rs671 *1/*2 Genotype is a Risk Factor for the Development of Alcoholic Liver Cirrhosis in Hakka Alcoholics International Journal of General Medicine aldh2 alcoholics alcoholic liver cirrhosis gene polymorphism hakka |
| title | ALDH2 Polymorphism rs671 *1/*2 Genotype is a Risk Factor for the Development of Alcoholic Liver Cirrhosis in Hakka Alcoholics |
| title_full | ALDH2 Polymorphism rs671 *1/*2 Genotype is a Risk Factor for the Development of Alcoholic Liver Cirrhosis in Hakka Alcoholics |
| title_fullStr | ALDH2 Polymorphism rs671 *1/*2 Genotype is a Risk Factor for the Development of Alcoholic Liver Cirrhosis in Hakka Alcoholics |
| title_full_unstemmed | ALDH2 Polymorphism rs671 *1/*2 Genotype is a Risk Factor for the Development of Alcoholic Liver Cirrhosis in Hakka Alcoholics |
| title_short | ALDH2 Polymorphism rs671 *1/*2 Genotype is a Risk Factor for the Development of Alcoholic Liver Cirrhosis in Hakka Alcoholics |
| title_sort | aldh2 polymorphism rs671 ast 1 ast 2 genotype is a risk factor for the development of alcoholic liver cirrhosis in hakka alcoholics |
| topic | aldh2 alcoholics alcoholic liver cirrhosis gene polymorphism hakka |
| url | https://www.dovepress.com/aldh2-polymorphism-rs671-12-genotype-is-a-risk-factor-for-the-developm-peer-reviewed-fulltext-article-IJGM |
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