Phenytoin-induced dyskinesia: a case report
Abstract Background Dyskinesia is a movement disorder categorized by involuntary movement of muscle. Although dyskinesia can be brought on by taking medications, it can also be a symptom of a variety of diseases. Antiepileptic drug-induced involuntary movements have been well researched. Rare report...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-07-01
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| Series: | Journal of Medical Case Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13256-023-04033-6 |
| _version_ | 1797774162869092352 |
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| author | Kashvi C. Shah Nishi S. Patel Paritosh Vasani Avinash Khadela Vivek P. Chavda Lalitkumar Vora |
| author_facet | Kashvi C. Shah Nishi S. Patel Paritosh Vasani Avinash Khadela Vivek P. Chavda Lalitkumar Vora |
| author_sort | Kashvi C. Shah |
| collection | DOAJ |
| description | Abstract Background Dyskinesia is a movement disorder categorized by involuntary movement of muscle. Although dyskinesia can be brought on by taking medications, it can also be a symptom of a variety of diseases. Antiepileptic drug-induced involuntary movements have been well researched. Rare reports have been made for dyskinesia, a type of dystonia caused by phenytoin. The mechanism of its occurrence must be succinctly studied. Case presentation A 53-year-old Asian patient taking phenytoin (100 mg twice daily) experienced symptoms of perioral muscle involuntary movement, impaired speech, and generalized tremors and was admitted to the hospital. Brain magnetic resonance imaging showed significant development of encephalomalacia and porencephaly. The serum phenytoin levels were in the toxic range (33 g/ml). These were suggestive of phenytoin-induced dyskinesia. Levetiracetam and clonazepam were initiated, and the patient showed significant improvement in the symptoms. Conclusion This case presented a substantial reference value for the differential diagnosis and treatment prognosis of phenytoin-induced dyskinesia. The phenytoin-induced dyskinesia in this patient was successfully reversed with prompt identification and treatment. According to the case study’s findings, such people may benefit from periodic therapeutic drug monitoring. |
| first_indexed | 2024-03-12T22:16:57Z |
| format | Article |
| id | doaj.art-8038240e333f434490268d101bf52a8c |
| institution | Directory Open Access Journal |
| issn | 1752-1947 |
| language | English |
| last_indexed | 2024-03-12T22:16:57Z |
| publishDate | 2023-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Medical Case Reports |
| spelling | doaj.art-8038240e333f434490268d101bf52a8c2023-07-23T11:15:34ZengBMCJournal of Medical Case Reports1752-19472023-07-011711310.1186/s13256-023-04033-6Phenytoin-induced dyskinesia: a case reportKashvi C. Shah0Nishi S. Patel1Paritosh Vasani2Avinash Khadela3Vivek P. Chavda4Lalitkumar Vora5L. M. College of PharmacyL. M. College of PharmacyGCS Medical College, Hospital and Research CentreDepartment of Pharmacology, L. M. College of PharmacyDepartment of Pharmaceutics and Pharmaceutical Technology, L. M. College of PharmacySchool of Pharmacy, Queen’s University BelfastAbstract Background Dyskinesia is a movement disorder categorized by involuntary movement of muscle. Although dyskinesia can be brought on by taking medications, it can also be a symptom of a variety of diseases. Antiepileptic drug-induced involuntary movements have been well researched. Rare reports have been made for dyskinesia, a type of dystonia caused by phenytoin. The mechanism of its occurrence must be succinctly studied. Case presentation A 53-year-old Asian patient taking phenytoin (100 mg twice daily) experienced symptoms of perioral muscle involuntary movement, impaired speech, and generalized tremors and was admitted to the hospital. Brain magnetic resonance imaging showed significant development of encephalomalacia and porencephaly. The serum phenytoin levels were in the toxic range (33 g/ml). These were suggestive of phenytoin-induced dyskinesia. Levetiracetam and clonazepam were initiated, and the patient showed significant improvement in the symptoms. Conclusion This case presented a substantial reference value for the differential diagnosis and treatment prognosis of phenytoin-induced dyskinesia. The phenytoin-induced dyskinesia in this patient was successfully reversed with prompt identification and treatment. According to the case study’s findings, such people may benefit from periodic therapeutic drug monitoring.https://doi.org/10.1186/s13256-023-04033-6PhenytoinDyskinesiaSeizuresAdverse drug reaction |
| spellingShingle | Kashvi C. Shah Nishi S. Patel Paritosh Vasani Avinash Khadela Vivek P. Chavda Lalitkumar Vora Phenytoin-induced dyskinesia: a case report Journal of Medical Case Reports Phenytoin Dyskinesia Seizures Adverse drug reaction |
| title | Phenytoin-induced dyskinesia: a case report |
| title_full | Phenytoin-induced dyskinesia: a case report |
| title_fullStr | Phenytoin-induced dyskinesia: a case report |
| title_full_unstemmed | Phenytoin-induced dyskinesia: a case report |
| title_short | Phenytoin-induced dyskinesia: a case report |
| title_sort | phenytoin induced dyskinesia a case report |
| topic | Phenytoin Dyskinesia Seizures Adverse drug reaction |
| url | https://doi.org/10.1186/s13256-023-04033-6 |
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