Influence of Angiotensin-Converting-Enzyme Gene Polymorphism on Echocardiographic Data of Patients with Ischemic Heart Failure
Abstract Background: Association between angiotensin-converting-enzyme (ACE) gene polymorphisms and different clinical and echocardiographic outcomes has been described in patients with heart failure (HF) and coronary artery disease. Studying the genetic profile of the local population with both di...
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Sociedade Brasileira de Cardiologia (SBC)
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| Series: | Arquivos Brasileiros de Cardiologia |
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| author | Gustavo Salgado Duque Dayse Aparecida da Silva Felipe Neves de Albuquerque Roberta Siuffo Schneider Alinne Gimenez Roberto Pozzan Ricardo Mourilhe Rocha Denilson Campos de Albuquerque |
| author_facet | Gustavo Salgado Duque Dayse Aparecida da Silva Felipe Neves de Albuquerque Roberta Siuffo Schneider Alinne Gimenez Roberto Pozzan Ricardo Mourilhe Rocha Denilson Campos de Albuquerque |
| author_sort | Gustavo Salgado Duque |
| collection | DOAJ |
| description | Abstract Background: Association between angiotensin-converting-enzyme (ACE) gene polymorphisms and different clinical and echocardiographic outcomes has been described in patients with heart failure (HF) and coronary artery disease. Studying the genetic profile of the local population with both diseases is necessary to assess the occurrence of that association. Objectives: To assess the frequency of ACE gene polymorphisms in patients with ischemic HF in a Rio de Janeiro population, as well as its association with echocardiographic findings. Methods: Genetic assessment of I/D ACE polymorphism in association with clinical, laboratory and echocardiographic analysis of 99 patients. Results: The allele frequency was: 53 I alleles, and 145 D alleles. Genotype frequencies were: 49.5% DD; 47.48% DI; 3.02% II. Drug treatment was optimized: 98% on beta-blockers, and 84.8% on ACE inhibitors or angiotensin-receptor blocker. Echocardiographic findings: difference between left ventricular diastolic diameters (ΔLVDD) during follow-up: 2.98±8.94 (DD) vs. 0.68±8.12 (DI) vs. -11.0±7.00 (II), p=0.018; worsening during follow-up of the LV systolic diameter (LVSD): 65.3% DD vs. 19.0% DI vs. 0.0% II, p=0.01; of the LV diastolic diameter (LVDD): 65.3% DD vs. 46.8% DI vs. 0.0% II, p=0.03; and of the LV ejection fraction (LVEF): 67.3% DD vs. 40.4% DI vs. 33.3% II, p=0.024. Correlated with D allele: ΔLVEF, ΔLVSD, ΔLVDD. Conclusions: More DD genotype patients had worsening of the LVEF, LVSD and LVDD, followed by DI genotype patients, while II genotype patients had the best outcome. The same pattern was observed for ΔLVDD. |
| first_indexed | 2024-12-11T09:16:22Z |
| format | Article |
| id | doaj.art-803958844a0c41389d0b391531c75e1c |
| institution | Directory Open Access Journal |
| issn | 1678-4170 |
| language | English |
| last_indexed | 2024-12-11T09:16:22Z |
| publisher | Sociedade Brasileira de Cardiologia (SBC) |
| record_format | Article |
| series | Arquivos Brasileiros de Cardiologia |
| spelling | doaj.art-803958844a0c41389d0b391531c75e1c2022-12-22T01:13:22ZengSociedade Brasileira de Cardiologia (SBC)Arquivos Brasileiros de Cardiologia1678-4170010.5935/abc.20160145S0066-782X2016005025102Influence of Angiotensin-Converting-Enzyme Gene Polymorphism on Echocardiographic Data of Patients with Ischemic Heart FailureGustavo Salgado DuqueDayse Aparecida da SilvaFelipe Neves de AlbuquerqueRoberta Siuffo SchneiderAlinne GimenezRoberto PozzanRicardo Mourilhe RochaDenilson Campos de AlbuquerqueAbstract Background: Association between angiotensin-converting-enzyme (ACE) gene polymorphisms and different clinical and echocardiographic outcomes has been described in patients with heart failure (HF) and coronary artery disease. Studying the genetic profile of the local population with both diseases is necessary to assess the occurrence of that association. Objectives: To assess the frequency of ACE gene polymorphisms in patients with ischemic HF in a Rio de Janeiro population, as well as its association with echocardiographic findings. Methods: Genetic assessment of I/D ACE polymorphism in association with clinical, laboratory and echocardiographic analysis of 99 patients. Results: The allele frequency was: 53 I alleles, and 145 D alleles. Genotype frequencies were: 49.5% DD; 47.48% DI; 3.02% II. Drug treatment was optimized: 98% on beta-blockers, and 84.8% on ACE inhibitors or angiotensin-receptor blocker. Echocardiographic findings: difference between left ventricular diastolic diameters (ΔLVDD) during follow-up: 2.98±8.94 (DD) vs. 0.68±8.12 (DI) vs. -11.0±7.00 (II), p=0.018; worsening during follow-up of the LV systolic diameter (LVSD): 65.3% DD vs. 19.0% DI vs. 0.0% II, p=0.01; of the LV diastolic diameter (LVDD): 65.3% DD vs. 46.8% DI vs. 0.0% II, p=0.03; and of the LV ejection fraction (LVEF): 67.3% DD vs. 40.4% DI vs. 33.3% II, p=0.024. Correlated with D allele: ΔLVEF, ΔLVSD, ΔLVDD. Conclusions: More DD genotype patients had worsening of the LVEF, LVSD and LVDD, followed by DI genotype patients, while II genotype patients had the best outcome. The same pattern was observed for ΔLVDD.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2016005025102&lng=en&tlng=enHeart FailurePolymorphism, GeneticAngiotensin-Converting Enzyme InhibitorsEchocardiography / methods |
| spellingShingle | Gustavo Salgado Duque Dayse Aparecida da Silva Felipe Neves de Albuquerque Roberta Siuffo Schneider Alinne Gimenez Roberto Pozzan Ricardo Mourilhe Rocha Denilson Campos de Albuquerque Influence of Angiotensin-Converting-Enzyme Gene Polymorphism on Echocardiographic Data of Patients with Ischemic Heart Failure Arquivos Brasileiros de Cardiologia Heart Failure Polymorphism, Genetic Angiotensin-Converting Enzyme Inhibitors Echocardiography / methods |
| title | Influence of Angiotensin-Converting-Enzyme Gene Polymorphism on Echocardiographic Data of Patients with Ischemic Heart Failure |
| title_full | Influence of Angiotensin-Converting-Enzyme Gene Polymorphism on Echocardiographic Data of Patients with Ischemic Heart Failure |
| title_fullStr | Influence of Angiotensin-Converting-Enzyme Gene Polymorphism on Echocardiographic Data of Patients with Ischemic Heart Failure |
| title_full_unstemmed | Influence of Angiotensin-Converting-Enzyme Gene Polymorphism on Echocardiographic Data of Patients with Ischemic Heart Failure |
| title_short | Influence of Angiotensin-Converting-Enzyme Gene Polymorphism on Echocardiographic Data of Patients with Ischemic Heart Failure |
| title_sort | influence of angiotensin converting enzyme gene polymorphism on echocardiographic data of patients with ischemic heart failure |
| topic | Heart Failure Polymorphism, Genetic Angiotensin-Converting Enzyme Inhibitors Echocardiography / methods |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2016005025102&lng=en&tlng=en |
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