Influence of hepatitis c in the development of histological and morfological changes in the placenta
The purpose: detection of morphological changes of fetoplacental complex in pregnant women with chronic hepatitis C.Methods: The study involved 48 pregnant women , 38 of them with chronic hepatitis C and 10 – healthy pregnant women without complicated obstetric – gynecological history. Do all women...
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| Format: | Article |
| Language: | Russian |
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Journal Infectology
2016-02-01
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| Series: | Журнал инфектологии |
| Subjects: | |
| Online Access: | https://journal.niidi.ru/jofin/article/view/449 |
| _version_ | 1826557907118850048 |
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| author | O. M. Filipovich N. I. Kuznetsov V. E. Karev E. A. Malahovskaya |
| author_facet | O. M. Filipovich N. I. Kuznetsov V. E. Karev E. A. Malahovskaya |
| author_sort | O. M. Filipovich |
| collection | DOAJ |
| description | The purpose: detection of morphological changes of fetoplacental complex in pregnant women with chronic hepatitis C.Methods: The study involved 48 pregnant women , 38 of them with chronic hepatitis C and 10 – healthy pregnant women without complicated obstetric – gynecological history. Do all women was conducted morphological and histological study of their placentas. Placental tissue samples were fixed in 10% formalin solution. After fixation in 10% neutral formalin, the samples were subjected to histological wiring placentas by incubation in isopropyl alcohol and paraffin imbibition using the apparatus for automatic wiring histological samples gated Exelsior (Thermo, Germany) .Immunogistohimicheskie (IHC) studies were performed using a mouse monoclonal antibody NS3-antigen to hepatitis C virus (at a dilution of 1/80, Novocastra Lab., UK).Results: chronic ( sub) compensated placental insufficiency often revealed by the presence of NS3-HCV in the placenta. In the presence of placental infection with hepatitis C virus ( HCV NS3 ) , the presence of more common detsiduita placenta.Conclusions: Hepatitis C virus is one of the most important factors in the development of chronic placental insufficiency. |
| first_indexed | 2024-03-12T04:46:01Z |
| format | Article |
| id | doaj.art-803a9e8c994646ddb06679a12f3ab3b0 |
| institution | Directory Open Access Journal |
| issn | 2072-6732 |
| language | Russian |
| last_indexed | 2025-03-14T08:36:03Z |
| publishDate | 2016-02-01 |
| publisher | Journal Infectology |
| record_format | Article |
| series | Журнал инфектологии |
| spelling | doaj.art-803a9e8c994646ddb06679a12f3ab3b02025-03-02T13:00:28ZrusJournal InfectologyЖурнал инфектологии2072-67322016-02-0174899410.22625/2072-6732-2015-7-4-89-94449Influence of hepatitis c in the development of histological and morfological changes in the placentaO. M. Filipovich0N. I. Kuznetsov1V. E. Karev2E. A. Malahovskaya3North-Western State Medical University named after I.I. Mechnikov, Saint-Petersburg, RussiaNorth-Western State Medical University named after I.I. Mechnikov, Saint-Petersburg, RussiaScience Research Institute of Children’s Infections, Saint-Petersburg, RussiaMaternity Hospital №18, Saint-Petersburg, RussiaThe purpose: detection of morphological changes of fetoplacental complex in pregnant women with chronic hepatitis C.Methods: The study involved 48 pregnant women , 38 of them with chronic hepatitis C and 10 – healthy pregnant women without complicated obstetric – gynecological history. Do all women was conducted morphological and histological study of their placentas. Placental tissue samples were fixed in 10% formalin solution. After fixation in 10% neutral formalin, the samples were subjected to histological wiring placentas by incubation in isopropyl alcohol and paraffin imbibition using the apparatus for automatic wiring histological samples gated Exelsior (Thermo, Germany) .Immunogistohimicheskie (IHC) studies were performed using a mouse monoclonal antibody NS3-antigen to hepatitis C virus (at a dilution of 1/80, Novocastra Lab., UK).Results: chronic ( sub) compensated placental insufficiency often revealed by the presence of NS3-HCV in the placenta. In the presence of placental infection with hepatitis C virus ( HCV NS3 ) , the presence of more common detsiduita placenta.Conclusions: Hepatitis C virus is one of the most important factors in the development of chronic placental insufficiency.https://journal.niidi.ru/jofin/article/view/449chronic hepatitis cpregnancyimmunohistochemistryplacentafetoplacental insufficiency |
| spellingShingle | O. M. Filipovich N. I. Kuznetsov V. E. Karev E. A. Malahovskaya Influence of hepatitis c in the development of histological and morfological changes in the placenta Журнал инфектологии chronic hepatitis c pregnancy immunohistochemistry placenta fetoplacental insufficiency |
| title | Influence of hepatitis c in the development of histological and morfological changes in the placenta |
| title_full | Influence of hepatitis c in the development of histological and morfological changes in the placenta |
| title_fullStr | Influence of hepatitis c in the development of histological and morfological changes in the placenta |
| title_full_unstemmed | Influence of hepatitis c in the development of histological and morfological changes in the placenta |
| title_short | Influence of hepatitis c in the development of histological and morfological changes in the placenta |
| title_sort | influence of hepatitis c in the development of histological and morfological changes in the placenta |
| topic | chronic hepatitis c pregnancy immunohistochemistry placenta fetoplacental insufficiency |
| url | https://journal.niidi.ru/jofin/article/view/449 |
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