The relationship between choline plus creatine- to-citrate ratio in magnetic resonance spectroscopy with the invasion of prostate cancer
Background: Prostate cancer is the most common cancer and the second cause of cancer mortality in men. Although histopathological examination is the gold-standard for its diagnosis, tendency toward less invasive methods is growing. The purpose of this study was to evaluate the relationship between c...
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| Format: | Article |
| Language: | fas |
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Tehran University of Medical Sciences
2012-12-01
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| Series: | Tehran University Medical Journal |
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| Online Access: | http://tumj.tums.ac.ir/browse.php?a_code=A-10-25-77&slc_lang=en&sid=1 |
| _version_ | 1818246085384077312 |
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| author | Ghafoori M Rasteh M |
| author_facet | Ghafoori M Rasteh M |
| author_sort | Ghafoori M |
| collection | DOAJ |
| description | Background: Prostate cancer is the most common cancer and the second cause of cancer mortality in men. Although histopathological examination is the gold-standard for its diagnosis, tendency toward less invasive methods is growing. The purpose of this study was to evaluate the relationship between choline plus creatine- to-citrate ratio in magnetic resonance spectroscopy (MRS) with the invasion of prostate cancer in a series of patients with prostate cancer.Methods: Totally, 200 patients with pathologically proven prostate cancer were enrolled in this cross-sectional study by a non-probability sampling method in Hazrat Rasul Akram Hospital in Tehran, Iran during 2009-2010. Pathological staging was the gold standard for the diagnosis of prostate cancer while the patients underwent MRS for choline plus creatine- to-citrate ratio determination. MRS and pathological results were compared and analyzed.Results: The mean (±SD) values of choline plus creatine- to-citrate ratio in patients with Gleason scores less than 3, 3 to 4 and greater than 4 were 245.8±146.8, 427.1±173.6 and 427.1±173.6, respectively (P<0.001). The mean (±SD) values of choline plus creatine- to-citrate ratio in patients with PSA levels less than 4, 4 to 10 and greater than 10 were 180.7±58.3, 247±93.5 and 385.1±106.6, respectively (P<0.001).Conclusion: Choline plus creatine- to-citrate ratio determined by magnetic resonance spectroscopy has a significant relationship with the degree of invasion of prostate cancer and can be used for the staging of the disease. |
| first_indexed | 2024-12-12T14:43:12Z |
| format | Article |
| id | doaj.art-803bbf9ab40a4270a6b8eb40e60d95b9 |
| institution | Directory Open Access Journal |
| issn | 1683-1764 1735-7322 |
| language | fas |
| last_indexed | 2024-12-12T14:43:12Z |
| publishDate | 2012-12-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Tehran University Medical Journal |
| spelling | doaj.art-803bbf9ab40a4270a6b8eb40e60d95b92022-12-22T00:21:10ZfasTehran University of Medical SciencesTehran University Medical Journal1683-17641735-73222012-12-01709571576The relationship between choline plus creatine- to-citrate ratio in magnetic resonance spectroscopy with the invasion of prostate cancerGhafoori M0Rasteh M1 Background: Prostate cancer is the most common cancer and the second cause of cancer mortality in men. Although histopathological examination is the gold-standard for its diagnosis, tendency toward less invasive methods is growing. The purpose of this study was to evaluate the relationship between choline plus creatine- to-citrate ratio in magnetic resonance spectroscopy (MRS) with the invasion of prostate cancer in a series of patients with prostate cancer.Methods: Totally, 200 patients with pathologically proven prostate cancer were enrolled in this cross-sectional study by a non-probability sampling method in Hazrat Rasul Akram Hospital in Tehran, Iran during 2009-2010. Pathological staging was the gold standard for the diagnosis of prostate cancer while the patients underwent MRS for choline plus creatine- to-citrate ratio determination. MRS and pathological results were compared and analyzed.Results: The mean (±SD) values of choline plus creatine- to-citrate ratio in patients with Gleason scores less than 3, 3 to 4 and greater than 4 were 245.8±146.8, 427.1±173.6 and 427.1±173.6, respectively (P<0.001). The mean (±SD) values of choline plus creatine- to-citrate ratio in patients with PSA levels less than 4, 4 to 10 and greater than 10 were 180.7±58.3, 247±93.5 and 385.1±106.6, respectively (P<0.001).Conclusion: Choline plus creatine- to-citrate ratio determined by magnetic resonance spectroscopy has a significant relationship with the degree of invasion of prostate cancer and can be used for the staging of the disease.http://tumj.tums.ac.ir/browse.php?a_code=A-10-25-77&slc_lang=en&sid=1cholinecitratecreatinemagnetic resonance spectroscopy (MRS)prostate cancer |
| spellingShingle | Ghafoori M Rasteh M The relationship between choline plus creatine- to-citrate ratio in magnetic resonance spectroscopy with the invasion of prostate cancer Tehran University Medical Journal choline citrate creatine magnetic resonance spectroscopy (MRS) prostate cancer |
| title | The relationship between choline plus creatine- to-citrate ratio in magnetic resonance spectroscopy with the invasion of prostate cancer |
| title_full | The relationship between choline plus creatine- to-citrate ratio in magnetic resonance spectroscopy with the invasion of prostate cancer |
| title_fullStr | The relationship between choline plus creatine- to-citrate ratio in magnetic resonance spectroscopy with the invasion of prostate cancer |
| title_full_unstemmed | The relationship between choline plus creatine- to-citrate ratio in magnetic resonance spectroscopy with the invasion of prostate cancer |
| title_short | The relationship between choline plus creatine- to-citrate ratio in magnetic resonance spectroscopy with the invasion of prostate cancer |
| title_sort | relationship between choline plus creatine to citrate ratio in magnetic resonance spectroscopy with the invasion of prostate cancer |
| topic | choline citrate creatine magnetic resonance spectroscopy (MRS) prostate cancer |
| url | http://tumj.tums.ac.ir/browse.php?a_code=A-10-25-77&slc_lang=en&sid=1 |
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