Is Bipolar Disorder the Consequence of a Genetic Weakness or Not Having Correctly Used a Potential Adaptive Condition?
It is hypothesized that factors associated with bipolar disorder could, uer defined conditions, produce adaptive behaviors. The aim is to verify whether a genetic feature associated with bipolar disorder can be found in people without bipolar disorder but with hyperactivity/exploration traits. Healt...
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| Format: | Article |
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MDPI AG
2022-12-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/13/1/16 |
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| author | Mauro Giovanni Carta Goce Kalcev Alessandra Scano Diego Primavera Germano Orrù Oye Gureye Giulia Cossu Antonio Egidio Nardi |
| author_facet | Mauro Giovanni Carta Goce Kalcev Alessandra Scano Diego Primavera Germano Orrù Oye Gureye Giulia Cossu Antonio Egidio Nardi |
| author_sort | Mauro Giovanni Carta |
| collection | DOAJ |
| description | It is hypothesized that factors associated with bipolar disorder could, uer defined conditions, produce adaptive behaviors. The aim is to verify whether a genetic feature associated with bipolar disorder can be found in people without bipolar disorder but with hyperactivity/exploration traits. Healthy old adults (N = 40) recruited for a previous study on exercise were subdivided using a previously validated tool into those with and without hyperactivity/exploration traits and compared with a group of old patients with bipolar disorder (N = 21). The genetic variant RS1006737 of CACNA1C was analyzed using blood samples, DNA extraction, real-time PCR, FRET probes, and SANGER method sequencing. People with hyperactivity/exploration traits and without bipolar disorder were like people with bipolar disorder regarding the frequency of the genetic variant (OR = 0.79, CI95%: 0.21–2.95), but were different from people without either hyperactivity/exploration traits and bipolar disorder (OR = 4.75, CI95%: 1.19–18.91). The combined group of people with hyperactivity/exploration traits without bipolar disorder plus people with bipolar disorder had a higher frequency of the variant than people without either hyperactivity/exploration traits or bipolar disorder (OR = 4.25, CI95%: 1.24–14.4). To consider the genetic profile of bipolar disorder not an aberrant condition opens the way to a new approach in which the adaptive potential would be a central point in psychosocial treatment in addition to drug therapy. Future research can confirm the results of our study. |
| first_indexed | 2024-03-09T13:24:26Z |
| format | Article |
| id | doaj.art-803e7f6c5af0442192f866c54008ab1f |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-09T13:24:26Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-803e7f6c5af0442192f866c54008ab1f2023-11-30T21:26:24ZengMDPI AGBrain Sciences2076-34252022-12-011311610.3390/brainsci13010016Is Bipolar Disorder the Consequence of a Genetic Weakness or Not Having Correctly Used a Potential Adaptive Condition?Mauro Giovanni Carta0Goce Kalcev1Alessandra Scano2Diego Primavera3Germano Orrù4Oye Gureye5Giulia Cossu6Antonio Egidio Nardi7Department of Medical Sciences and Public Health, University of Cagliari, Monserato Blocco I (CA), 09042 Cagliari, ItalyInternational Ph.D. in Innovation Sciences and Technology, University of Cagliari, Via Università 40, 09124 Cagliari, ItalyDepartment of Surgical Sciences, University of Cagliari, Asse Didattico Medicina P2—Monserrato (CA), 09042 Cagliari, ItalyDepartment of Medical Sciences and Public Health, University of Cagliari, Monserato Blocco I (CA), 09042 Cagliari, ItalyDepartment of Surgical Sciences, University of Cagliari, Asse Didattico Medicina P2—Monserrato (CA), 09042 Cagliari, ItalyWHO Collaborating Centre for Research and Training in Mental Health, Neuroscience and Substance Abuse, Department of Psychiatry, University of Ibadan, Oduduwa Road, Ibadan 200132, NigeriaDepartment of Medical Sciences and Public Health, University of Cagliari, Monserato Blocco I (CA), 09042 Cagliari, ItalyLaboratory Panic and Respiration, Institute of Psychiatry (Ipub), Federal University of Rio De Janeiro (Ufrj), Rio De Janeiro 22725, BrazilIt is hypothesized that factors associated with bipolar disorder could, uer defined conditions, produce adaptive behaviors. The aim is to verify whether a genetic feature associated with bipolar disorder can be found in people without bipolar disorder but with hyperactivity/exploration traits. Healthy old adults (N = 40) recruited for a previous study on exercise were subdivided using a previously validated tool into those with and without hyperactivity/exploration traits and compared with a group of old patients with bipolar disorder (N = 21). The genetic variant RS1006737 of CACNA1C was analyzed using blood samples, DNA extraction, real-time PCR, FRET probes, and SANGER method sequencing. People with hyperactivity/exploration traits and without bipolar disorder were like people with bipolar disorder regarding the frequency of the genetic variant (OR = 0.79, CI95%: 0.21–2.95), but were different from people without either hyperactivity/exploration traits and bipolar disorder (OR = 4.75, CI95%: 1.19–18.91). The combined group of people with hyperactivity/exploration traits without bipolar disorder plus people with bipolar disorder had a higher frequency of the variant than people without either hyperactivity/exploration traits or bipolar disorder (OR = 4.25, CI95%: 1.24–14.4). To consider the genetic profile of bipolar disorder not an aberrant condition opens the way to a new approach in which the adaptive potential would be a central point in psychosocial treatment in addition to drug therapy. Future research can confirm the results of our study.https://www.mdpi.com/2076-3425/13/1/16bipolar disorderhyperactivity evolutionary perspectiveRS1006737CACNA1C |
| spellingShingle | Mauro Giovanni Carta Goce Kalcev Alessandra Scano Diego Primavera Germano Orrù Oye Gureye Giulia Cossu Antonio Egidio Nardi Is Bipolar Disorder the Consequence of a Genetic Weakness or Not Having Correctly Used a Potential Adaptive Condition? Brain Sciences bipolar disorder hyperactivity evolutionary perspective RS1006737 CACNA1C |
| title | Is Bipolar Disorder the Consequence of a Genetic Weakness or Not Having Correctly Used a Potential Adaptive Condition? |
| title_full | Is Bipolar Disorder the Consequence of a Genetic Weakness or Not Having Correctly Used a Potential Adaptive Condition? |
| title_fullStr | Is Bipolar Disorder the Consequence of a Genetic Weakness or Not Having Correctly Used a Potential Adaptive Condition? |
| title_full_unstemmed | Is Bipolar Disorder the Consequence of a Genetic Weakness or Not Having Correctly Used a Potential Adaptive Condition? |
| title_short | Is Bipolar Disorder the Consequence of a Genetic Weakness or Not Having Correctly Used a Potential Adaptive Condition? |
| title_sort | is bipolar disorder the consequence of a genetic weakness or not having correctly used a potential adaptive condition |
| topic | bipolar disorder hyperactivity evolutionary perspective RS1006737 CACNA1C |
| url | https://www.mdpi.com/2076-3425/13/1/16 |
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