Cardiac sympathetic modulation in response to apneas/hypopneas through heart rate variability analysis.
Autonomic dysfunction is recognized to contribute to cardiovascular consequences in obstructive sleep apnea/hypopnea syndrome (OSAHS) patients who present predominant cardiovascular sympathetic activity that persists during wakefulness. Here, we examined 1) the factors that influence sympathetic car...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3899280?pdf=render |
| _version_ | 1819012021281095680 |
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| author | Florian Chouchou Vincent Pichot Jean-Claude Barthélémy Hélène Bastuji Frédéric Roche |
| author_facet | Florian Chouchou Vincent Pichot Jean-Claude Barthélémy Hélène Bastuji Frédéric Roche |
| author_sort | Florian Chouchou |
| collection | DOAJ |
| description | Autonomic dysfunction is recognized to contribute to cardiovascular consequences in obstructive sleep apnea/hypopnea syndrome (OSAHS) patients who present predominant cardiovascular sympathetic activity that persists during wakefulness. Here, we examined 1) the factors that influence sympathetic cardiac modulation in response to apneas/hypopneas; and 2) the influence of autonomic activity during apneas/hypopneas on CA. Sixteen OSAHS patients underwent in-hospital polysomnography. RR interval (RR) and RR spectral analysis using wavelet transform were used to study parasympathetic (high frequency power: HF(WV)) and sympathetic (low frequency power: LF(WV) and LF(WV)/HF(WV) ratio) activity before and after apnea/hypopnea termination. Autonomic cardiac modulations were compared according to sleep stage, apnea/hypopnea type and duration, arterial oxygen saturation, and presence of CA. At apnea/hypopnea termination, RR decreased (p<0.001) while LF(WV) (p = 0.001) and LF(WV)/HF(WV) ratio (p = 0.001) increased. Only RR and LF(WV)/HF(WV) ratio changes were higher when apneas/hypopneas produced CA (p = 0.030 and p = 0.035, respectively) or deep hypoxia (p = 0.023 and p = 0.046, respectively). Multivariate statistical analysis showed that elevated LF(WV) (p = 0.006) and LF(WV)/HF(WV) ratio (p = 0.029) during apneas/hypopneas were independently related to higher CA occurrence. Both the arousal and hypoxia processes may contribute to sympathetic cardiovascular overactivity by recurrent cardiac sympathetic modulation in response to apneas/hypopneas. Sympathetic overactivity also may play an important role in the acute central response to apneas/hypopneas, and in the sleep fragmentation. |
| first_indexed | 2024-12-21T01:37:25Z |
| format | Article |
| id | doaj.art-803ef6f4ef26405bbef50640ddc5f035 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T01:37:25Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-803ef6f4ef26405bbef50640ddc5f0352022-12-21T19:20:15ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0191e8643410.1371/journal.pone.0086434Cardiac sympathetic modulation in response to apneas/hypopneas through heart rate variability analysis.Florian ChouchouVincent PichotJean-Claude BarthélémyHélène BastujiFrédéric RocheAutonomic dysfunction is recognized to contribute to cardiovascular consequences in obstructive sleep apnea/hypopnea syndrome (OSAHS) patients who present predominant cardiovascular sympathetic activity that persists during wakefulness. Here, we examined 1) the factors that influence sympathetic cardiac modulation in response to apneas/hypopneas; and 2) the influence of autonomic activity during apneas/hypopneas on CA. Sixteen OSAHS patients underwent in-hospital polysomnography. RR interval (RR) and RR spectral analysis using wavelet transform were used to study parasympathetic (high frequency power: HF(WV)) and sympathetic (low frequency power: LF(WV) and LF(WV)/HF(WV) ratio) activity before and after apnea/hypopnea termination. Autonomic cardiac modulations were compared according to sleep stage, apnea/hypopnea type and duration, arterial oxygen saturation, and presence of CA. At apnea/hypopnea termination, RR decreased (p<0.001) while LF(WV) (p = 0.001) and LF(WV)/HF(WV) ratio (p = 0.001) increased. Only RR and LF(WV)/HF(WV) ratio changes were higher when apneas/hypopneas produced CA (p = 0.030 and p = 0.035, respectively) or deep hypoxia (p = 0.023 and p = 0.046, respectively). Multivariate statistical analysis showed that elevated LF(WV) (p = 0.006) and LF(WV)/HF(WV) ratio (p = 0.029) during apneas/hypopneas were independently related to higher CA occurrence. Both the arousal and hypoxia processes may contribute to sympathetic cardiovascular overactivity by recurrent cardiac sympathetic modulation in response to apneas/hypopneas. Sympathetic overactivity also may play an important role in the acute central response to apneas/hypopneas, and in the sleep fragmentation.http://europepmc.org/articles/PMC3899280?pdf=render |
| spellingShingle | Florian Chouchou Vincent Pichot Jean-Claude Barthélémy Hélène Bastuji Frédéric Roche Cardiac sympathetic modulation in response to apneas/hypopneas through heart rate variability analysis. PLoS ONE |
| title | Cardiac sympathetic modulation in response to apneas/hypopneas through heart rate variability analysis. |
| title_full | Cardiac sympathetic modulation in response to apneas/hypopneas through heart rate variability analysis. |
| title_fullStr | Cardiac sympathetic modulation in response to apneas/hypopneas through heart rate variability analysis. |
| title_full_unstemmed | Cardiac sympathetic modulation in response to apneas/hypopneas through heart rate variability analysis. |
| title_short | Cardiac sympathetic modulation in response to apneas/hypopneas through heart rate variability analysis. |
| title_sort | cardiac sympathetic modulation in response to apneas hypopneas through heart rate variability analysis |
| url | http://europepmc.org/articles/PMC3899280?pdf=render |
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