Critical Review of the Evolution of Extracellular Vesicles’ Knowledge: From 1946 to Today
Extracellular vesicles (EVs) are a family of particles/vesicles present in blood and body fluids, composed of phospholipid bilayers that carry a variety of molecules that can mediate cell communication, modulating crucial cell processes such as homeostasis, induction/dampening of inflammation, and p...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/12/6417 |
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| author | Erica Bazzan Mariaenrica Tinè Alvise Casara Davide Biondini Umberto Semenzato Elisabetta Cocconcelli Elisabetta Balestro Marco Damin Claudia Maria Radu Graziella Turato Simonetta Baraldo Paolo Simioni Paolo Spagnolo Marina Saetta Manuel G. Cosio |
| author_facet | Erica Bazzan Mariaenrica Tinè Alvise Casara Davide Biondini Umberto Semenzato Elisabetta Cocconcelli Elisabetta Balestro Marco Damin Claudia Maria Radu Graziella Turato Simonetta Baraldo Paolo Simioni Paolo Spagnolo Marina Saetta Manuel G. Cosio |
| author_sort | Erica Bazzan |
| collection | DOAJ |
| description | Extracellular vesicles (EVs) are a family of particles/vesicles present in blood and body fluids, composed of phospholipid bilayers that carry a variety of molecules that can mediate cell communication, modulating crucial cell processes such as homeostasis, induction/dampening of inflammation, and promotion of repair. Their existence, initially suspected in 1946 and confirmed in 1967, spurred a sharp increase in the number of scientific publications. Paradoxically, the increasing interest for EV content and function progressively reduced the relevance for a precise nomenclature in classifying EVs, therefore leading to a confusing scientific production. The aim of this review was to analyze the evolution of the progress in the knowledge and definition of EVs over the years, with an overview of the methodologies used for the identification of the vesicles, their cell of origin, and the detection of their cargo. The MISEV 2018 guidelines for the proper recognition nomenclature and ways to study EVs are summarized. The review finishes with a “more questions than answers” chapter, in which some of the problems we still face to fully understand the EV function and potential as a diagnostic and therapeutic tool are analyzed. |
| first_indexed | 2024-03-10T10:23:35Z |
| format | Article |
| id | doaj.art-8041d5b3ea5143c491d1b7f4e4bb5ad9 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T10:23:35Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-8041d5b3ea5143c491d1b7f4e4bb5ad92023-11-22T00:15:35ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-06-012212641710.3390/ijms22126417Critical Review of the Evolution of Extracellular Vesicles’ Knowledge: From 1946 to TodayErica Bazzan0Mariaenrica Tinè1Alvise Casara2Davide Biondini3Umberto Semenzato4Elisabetta Cocconcelli5Elisabetta Balestro6Marco Damin7Claudia Maria Radu8Graziella Turato9Simonetta Baraldo10Paolo Simioni11Paolo Spagnolo12Marina Saetta13Manuel G. Cosio14Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, 35128 Padova, ItalyDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, 35128 Padova, ItalyDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, 35128 Padova, ItalyDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, 35128 Padova, ItalyDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, 35128 Padova, ItalyDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, 35128 Padova, ItalyDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, 35128 Padova, ItalyDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, 35128 Padova, ItalyDepartment of Women’s and Children’s Health, University of Padova, 35128 Padova, ItalyDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, 35128 Padova, ItalyDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, 35128 Padova, ItalyDepartment of Medicine, University of Padova, 35128 Padova, ItalyDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, 35128 Padova, ItalyDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, 35128 Padova, ItalyDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, 35128 Padova, ItalyExtracellular vesicles (EVs) are a family of particles/vesicles present in blood and body fluids, composed of phospholipid bilayers that carry a variety of molecules that can mediate cell communication, modulating crucial cell processes such as homeostasis, induction/dampening of inflammation, and promotion of repair. Their existence, initially suspected in 1946 and confirmed in 1967, spurred a sharp increase in the number of scientific publications. Paradoxically, the increasing interest for EV content and function progressively reduced the relevance for a precise nomenclature in classifying EVs, therefore leading to a confusing scientific production. The aim of this review was to analyze the evolution of the progress in the knowledge and definition of EVs over the years, with an overview of the methodologies used for the identification of the vesicles, their cell of origin, and the detection of their cargo. The MISEV 2018 guidelines for the proper recognition nomenclature and ways to study EVs are summarized. The review finishes with a “more questions than answers” chapter, in which some of the problems we still face to fully understand the EV function and potential as a diagnostic and therapeutic tool are analyzed.https://www.mdpi.com/1422-0067/22/12/6417exosomesmicrovesiclesmultivesicular bodiesliposomes |
| spellingShingle | Erica Bazzan Mariaenrica Tinè Alvise Casara Davide Biondini Umberto Semenzato Elisabetta Cocconcelli Elisabetta Balestro Marco Damin Claudia Maria Radu Graziella Turato Simonetta Baraldo Paolo Simioni Paolo Spagnolo Marina Saetta Manuel G. Cosio Critical Review of the Evolution of Extracellular Vesicles’ Knowledge: From 1946 to Today International Journal of Molecular Sciences exosomes microvesicles multivesicular bodies liposomes |
| title | Critical Review of the Evolution of Extracellular Vesicles’ Knowledge: From 1946 to Today |
| title_full | Critical Review of the Evolution of Extracellular Vesicles’ Knowledge: From 1946 to Today |
| title_fullStr | Critical Review of the Evolution of Extracellular Vesicles’ Knowledge: From 1946 to Today |
| title_full_unstemmed | Critical Review of the Evolution of Extracellular Vesicles’ Knowledge: From 1946 to Today |
| title_short | Critical Review of the Evolution of Extracellular Vesicles’ Knowledge: From 1946 to Today |
| title_sort | critical review of the evolution of extracellular vesicles knowledge from 1946 to today |
| topic | exosomes microvesicles multivesicular bodies liposomes |
| url | https://www.mdpi.com/1422-0067/22/12/6417 |
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