Effect of Antimicrobial Stewardship on Oral Quinolone Use and Resistance Patterns over 8 Years (2013–2020)
Since 2014, several global and national guidelines have been introduced to address the problem of antimicrobial resistance. We conducted a campaign in a tertiary hospital to promote appropriate quinolone use through educational lectures in 2018. The aim of this retrospective study was to evaluate th...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/10/11/1426 |
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| author | Atsushi Uda Katsumi Shigemura Koichi Kitagawa Kayo Osawa Mari Kusuki Yonmin Yan Ikuko Yano Takayuki Miyara |
| author_facet | Atsushi Uda Katsumi Shigemura Koichi Kitagawa Kayo Osawa Mari Kusuki Yonmin Yan Ikuko Yano Takayuki Miyara |
| author_sort | Atsushi Uda |
| collection | DOAJ |
| description | Since 2014, several global and national guidelines have been introduced to address the problem of antimicrobial resistance. We conducted a campaign in a tertiary hospital to promote appropriate quinolone use through educational lectures in 2018. The aim of this retrospective study was to evaluate the changes in the following: prescription characteristics, trend of oral quinolone use, and antibiotic susceptibility of bacteria from 2013 to 2020. Antimicrobial use was assessed as days of therapy per 1000 patient-days. We found a significant reduction in unnecessary antibiotic prescriptions between December 2013 and December 2020. Significant negative trends were detected in the use of quinolones over 8 years (outpatients, coefficient = −0.15655, <i>p</i> < 0.001; inpatients, coefficient = −0.004825, <i>p</i> = 0.0016). In particular, the monthly mean use of quinolones among outpatients significantly decreased by 11% from 2013 to 2014 (<i>p</i> < 0.05) and reduced further by 31% from 2017 to 2020 (<i>p</i> < 0.001). A significant positive trend was observed in the susceptibility of <i>Pseudomonas aeruginosa</i> to levofloxacin (<i>p</i> < 0.001). These results demonstrate that the use of oral quinolones was further reduced following educational intervention and the bacterial susceptibility improved with optimal quinolone usage compared to that in 2013. |
| first_indexed | 2024-03-10T05:45:15Z |
| format | Article |
| id | doaj.art-804391c1496e441c96e9402b35df2e4e |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-10T05:45:15Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-804391c1496e441c96e9402b35df2e4e2023-11-22T22:11:30ZengMDPI AGAntibiotics2079-63822021-11-011011142610.3390/antibiotics10111426Effect of Antimicrobial Stewardship on Oral Quinolone Use and Resistance Patterns over 8 Years (2013–2020)Atsushi Uda0Katsumi Shigemura1Koichi Kitagawa2Kayo Osawa3Mari Kusuki4Yonmin Yan5Ikuko Yano6Takayuki Miyara7Department of Infection Control and Prevention, Kobe University Hospital, Kobe 650-0017, JapanDepartment of Infection Control and Prevention, Kobe University Hospital, Kobe 650-0017, JapanDivision of Infectious Diseases, Department of Public Health, Graduate School of Medicine, Kobe University, Kobe 654-0142, JapanDepartment of Medical Technology, Kobe Tokiwa University, Kobe 653-0838, JapanDepartment of Infection Control and Prevention, Kobe University Hospital, Kobe 650-0017, JapanDivision of Urology, Graduate School of Medicine, Kobe University, Kobe 650-0017, JapanDepartment of Pharmacy, Kobe University Hospital, Kobe 650-0017, JapanDepartment of Infection Control and Prevention, Kobe University Hospital, Kobe 650-0017, JapanSince 2014, several global and national guidelines have been introduced to address the problem of antimicrobial resistance. We conducted a campaign in a tertiary hospital to promote appropriate quinolone use through educational lectures in 2018. The aim of this retrospective study was to evaluate the changes in the following: prescription characteristics, trend of oral quinolone use, and antibiotic susceptibility of bacteria from 2013 to 2020. Antimicrobial use was assessed as days of therapy per 1000 patient-days. We found a significant reduction in unnecessary antibiotic prescriptions between December 2013 and December 2020. Significant negative trends were detected in the use of quinolones over 8 years (outpatients, coefficient = −0.15655, <i>p</i> < 0.001; inpatients, coefficient = −0.004825, <i>p</i> = 0.0016). In particular, the monthly mean use of quinolones among outpatients significantly decreased by 11% from 2013 to 2014 (<i>p</i> < 0.05) and reduced further by 31% from 2017 to 2020 (<i>p</i> < 0.001). A significant positive trend was observed in the susceptibility of <i>Pseudomonas aeruginosa</i> to levofloxacin (<i>p</i> < 0.001). These results demonstrate that the use of oral quinolones was further reduced following educational intervention and the bacterial susceptibility improved with optimal quinolone usage compared to that in 2013.https://www.mdpi.com/2079-6382/10/11/1426antimicrobial stewardshipunnecessary antibiotic prescriptionoral quinolonebacterial resistanceeducational intervention |
| spellingShingle | Atsushi Uda Katsumi Shigemura Koichi Kitagawa Kayo Osawa Mari Kusuki Yonmin Yan Ikuko Yano Takayuki Miyara Effect of Antimicrobial Stewardship on Oral Quinolone Use and Resistance Patterns over 8 Years (2013–2020) Antibiotics antimicrobial stewardship unnecessary antibiotic prescription oral quinolone bacterial resistance educational intervention |
| title | Effect of Antimicrobial Stewardship on Oral Quinolone Use and Resistance Patterns over 8 Years (2013–2020) |
| title_full | Effect of Antimicrobial Stewardship on Oral Quinolone Use and Resistance Patterns over 8 Years (2013–2020) |
| title_fullStr | Effect of Antimicrobial Stewardship on Oral Quinolone Use and Resistance Patterns over 8 Years (2013–2020) |
| title_full_unstemmed | Effect of Antimicrobial Stewardship on Oral Quinolone Use and Resistance Patterns over 8 Years (2013–2020) |
| title_short | Effect of Antimicrobial Stewardship on Oral Quinolone Use and Resistance Patterns over 8 Years (2013–2020) |
| title_sort | effect of antimicrobial stewardship on oral quinolone use and resistance patterns over 8 years 2013 2020 |
| topic | antimicrobial stewardship unnecessary antibiotic prescription oral quinolone bacterial resistance educational intervention |
| url | https://www.mdpi.com/2079-6382/10/11/1426 |
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